Zika virus co-opts microRNA networks to persist in placental niches detected by spatial transcriptomics

• Published in: American journal of obstetrics and gynecology Vol. 230; no. 2; pp. 251.e1 - 251.e17
• Main Authors: Barrozo, Enrico R., Seferovic, Maxim D., Hamilton, Mark P., Moorshead, David N., Jochum, Michael D., Do, Trang, O’Neil, Derek S., Suter, Melissa A., Aagaard, Kjersti M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2024
• Subjects: Animals; congenital virus; enoxacin; Enoxacin - metabolism; Female; Fetal Growth Retardation - metabolism; Gene Expression Profiling; gnotobiotic; Humans; maternal-fetal; Mice; microRNA; MicroRNAs - genetics; MicroRNAs - metabolism; pathogenesis; Placenta - metabolism; Pregnancy; ribonomics; RNA-Induced Silencing Complex - metabolism; Transforming Growth Factors - metabolism; trophoblast; Trophoblasts - metabolism; Visium; Zika virus; Zika Virus - genetics; Zika Virus Infection - genetics; ribonomics; pathogenesis; pregnancy; gnotobiotic; microRNA; congenital virus; Zika virus; maternal-fetal; trophoblast; enoxacin; Visium

Zika virus congenital infection evades double-stranded RNA detection and may persist in the placenta for the duration of pregnancy without accompanying overt histopathologic inflammation. Understanding how viruses can persist and replicate in the placenta without causing overt cellular or tissue dam...