The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis

• Published in: Nephrology, dialysis, transplantation Vol. 26; no. 4; pp. 1327 - 1339
• Main Authors: Raggi, P., Chertow, G. M., Torres, P. U., Csiky, B., Naso, A., Nossuli, K., Moustafa, M., Goodman, W. G., Lopez, N., Downey, G., Dehmel, B., Floege, J.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.2011
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Aorta; Aortic valve; Biological and medical sciences; Calcification; Calcification (ectopic); Calcinosis - drug therapy; Calcinosis - etiology; Calcitriol; Calcium; Cinacalcet Hydrochloride; Clinical trials; Computed tomography; coronary artery; Coronary Artery Disease - drug therapy; Coronary Artery Disease - etiology; Dose-Response Relationship, Drug; Emergency and intensive care: renal failure. Dialysis management; Female; Follow-Up Studies; General and cellular metabolism. Vitamins; Heart; Hemodialysis; Humans; Hyperparathyroidism; Hyperparathyroidism, Secondary - drug therapy; Hyperparathyroidism, Secondary - etiology; Intensive care medicine; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - therapy; Male; Medical sciences; Middle Aged; Mitral valve; Naphthalenes - therapeutic use; Parathyroid hormone; Pharmacology. Drug treatments; Phosphate; Prognosis; Prospective Studies; Renal Dialysis; Sterols; Vitamin D; Vitamin D - therapeutic use; Vitamins - therapeutic use; Endocrinopathy; Kidney disease; Human; Urinary system disease; secondary hyperparathyroidism; Calcimimetic agent; Hemodialysis; Low dose; Peptide hormone; Antihormone; Extrarenal dialysis; Vitamin D; Parathyroid hormone; Parathyroid diseases; Renal failure; Calcification; Cinacalcet; Hyperparathyroidism

This prospective, randomized, controlled trial compared the progression of vascular and cardiac valve calcification in 360 prevalent adult hemodialysis patients with secondary hyperparathyroidism treated with either cinacalcet plus low-dose vitamin D sterols or flexible doses of vitamin D sterols al...