Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia

• Published in: American journal of obstetrics and gynecology Vol. 226; no. 2; pp. S895 - S906
• Main Authors: Staff, Anne Cathrine, Fjeldstad, Heidi E., Fosheim, Ingrid Knutsdotter, Moe, Kjartan, Turowski, Gitta, Johnsen, Guro Mørk, Alnaes-Katjavivi, Patji, Sugulle, Meryam
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2022
• Subjects: Atherosclerosis - physiopathology; decidua; Decidua - blood supply; Decidua - pathology; Female; Humans; hypertension; immunology; pathophysiology; placenta; Placenta - blood supply; Placentation - physiology; Pre-Eclampsia - physiopathology; preeclampsia; Pregnancy; spiral artery; Trophoblasts - physiology; Uterine Artery - physiology; Uterine Artery - physiopathology; Vascular Remodeling - physiology; decidua; spiral artery; pathophysiology; pregnancy; placenta; preeclampsia; hypertension; immunology

Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a successful placentation and normal placental function. It is an intricate process that involves, but is not restricted to, complex interactions between maternal decidual immune cells and invasive trophobla...