Brain metabolite changes in cortical grey and normal‐appearing white matter in clinically early relapsing–remitting multiple sclerosis

• Published in: Brain (London, England : 1878) Vol. 125; no. 10; pp. 2342 - 2352
• Main Authors: Chard, D. T., Griffin, C. M., McLean, M. A., Kapeller, P., Kapoor, R., Thompson, A. J., Miller, D. H.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2002; Oxford Publishing Limited (England)
• Subjects: 1H‐MRSI = proton magnetic resonance spectroscopic imaging; 9HPT = nine hole peg test; Adult; Biological and medical sciences; BP = brain parenchymal; BPF = brain parenchymal fraction; Brain - metabolism; CGM = cortical grey matter; Cho = choline containing compounds; Cohort Studies; Cr = creatine and phosphocreatine; EDSS = expanded disability status scale; Female; FSE = fast spin echo; Glx = glutamate plus glutamine; GM = grey matter; GMF = grey matter fraction; grey matter; Humans; Ins = myo‐inositol; Linear Models; Magnetic Resonance Spectroscopy - statistics & numerical data; Male; Medical sciences; metabolite concentrations; Middle Aged; MSFC = multiple sclerosis functional composite; multiple sclerosis; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Multiple Sclerosis, Relapsing-Remitting - metabolism; NAWM = normal‐appearing white matter; NC = normal control; Neurology; normal‐appearing white matter; PASAT = paced auditory serial addition test; PRESS = point resolved spectroscopic; proton magnetic resonance spectroscopic imaging; Statistics, Nonparametric; TI = total intracranial; tNAA = N‐acetyl‐aspartate plus N‐acetyl‐aspartyl‐glutamate; TWT = timed walk test; WM = white matter; WMF = white matter fraction; Human; Nervous system diseases; Relapse; Multiple sclerosis; Pathophysiology; Grey matter; NMR spectrometry; Metabolism; Nuclear magnetic resonance imaging; Inflammatory disease; Central nervous system disease; Medical imagery; Remission; Brain (vertebrata)

While much work has concentrated on focal white matter (WM) lesions in multiple sclerosis, there is growing evidence to suggest that normal‐appearing WM (NAWM) and grey matter (GM) are also involved in the disease process. This study investigated multiple sclerosis disease effects on NAWM and cortic...