Reduction of colitis in mice by chemically programmed supramolecular nanoassemblies of vitamin–lipid conjugates

• Published in: Journal of nanobiotechnology Vol. 23; no. 1; pp. 247 - 19
• Main Authors: Xian, Shiyun, Meng, Fanchao, Chen, Xiaona, Zhu, Liqing, Wang, Hangxiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.03.2025; BioMed Central; BMC
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Antioxidants; Ascorbic Acid - chemistry; Ascorbic Acid - pharmacokinetics; Ascorbic Acid - pharmacology; Ascorbic Acid - therapeutic use; Budesonide; Budesonide - chemistry; Budesonide - pharmacology; Care and treatment; Colitis; Colitis - chemically induced; Colitis - drug therapy; Dextran; Dextran Sulfate; Diet therapy; Disease Models, Animal; Disease susceptibility; Fatty acids; Gastrointestinal system; Health aspects; Humans; Inflammation; Inflammatory bowel disease; Lipid conjugate; Lipids; Lipids - chemistry; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Nanoparticles - chemistry; Reactive Oxygen Species - metabolism; Self-assembly; Sulfates; Testing; Vitamin C; Vitamins; China; Illinois; Inflammatory bowel disease; Budesonide; Self-assembly; Lipid conjugate; Vitamin C

Inflammatory bowel disease (IBD) is a relapsing disorder characterized by uncontrolled chronic inflammation of the gastrointestinal tract, posing a significant therapeutic challenge owing to the limited efficacy and undesirable side effects of current therapeutic options. A key pathological hallmark...