In Situ Forming of Nitric Oxide and Electric Stimulus for Nerve Therapy by Wireless Chargeable Gold Yarn‐Dynamos
Endogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and electrical stimulation in clinical settings can be challenging due to NO's short half‐life and the invasive elect...
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Published in | Advanced science Vol. 10; no. 33; pp. e2303566 - n/a |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
John Wiley & Sons, Inc
01.11.2023
Wiley |
Subjects | |
Online Access | Get full text |
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Abstract | Endogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and electrical stimulation in clinical settings can be challenging due to NO's short half‐life and the invasive electrodes required for electrical stimulation. Additionally, there is a lack of tools to spatiotemporally control gas release and electrical stimulation. To address these issues, an “electromagnetic messenger” approach that employs on‐demand high‐frequency magnetic field (HFMF) to trigger NO release and electrical stimulation for restoring brain function in cases of traumatic brain injury is introduced. The system comprises a NO donor (poly(S‐nitrosoglutathione), pGSNO)‐conjugated on a gold yarn‐dynamos (GY) and embedded in an implantable silk in a microneedle. When subjected to HFMF, conductive GY induces eddy currents that stimulate the release of NO from pGSNO. This process significantly enhances neural stem cell (NSC) synapses' differentiation and growth. The combined strategy of using NO and electrical stimulation to inhibit inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury is demonstrated in vivo.
An “electromagnetic messenger” approach utilizing high‐frequency magnetic fields (HFMF) to trigger nitric oxide (NO) release and electrical stimulation is developed for restoring brain function in traumatic brain injury. Upon exposure to HFMF, in vivo experiments demonstrated the combined strategy's effectiveness in inhibiting inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury. |
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AbstractList | Endogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and electrical stimulation in clinical settings can be challenging due to NO's short half-life and the invasive electrodes required for electrical stimulation. Additionally, there is a lack of tools to spatiotemporally control gas release and electrical stimulation. To address these issues, an "electromagnetic messenger" approach that employs on-demand high-frequency magnetic field (HFMF) to trigger NO release and electrical stimulation for restoring brain function in cases of traumatic brain injury is introduced. The system comprises a NO donor (poly(S-nitrosoglutathione), pGSNO)-conjugated on a gold yarn-dynamos (GY) and embedded in an implantable silk in a microneedle. When subjected to HFMF, conductive GY induces eddy currents that stimulate the release of NO from pGSNO. This process significantly enhances neural stem cell (NSC) synapses' differentiation and growth. The combined strategy of using NO and electrical stimulation to inhibit inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury is demonstrated in vivo. Abstract Endogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and electrical stimulation in clinical settings can be challenging due to NO's short half‐life and the invasive electrodes required for electrical stimulation. Additionally, there is a lack of tools to spatiotemporally control gas release and electrical stimulation. To address these issues, an “electromagnetic messenger” approach that employs on‐demand high‐frequency magnetic field (HFMF) to trigger NO release and electrical stimulation for restoring brain function in cases of traumatic brain injury is introduced. The system comprises a NO donor (poly(S‐nitrosoglutathione), pGSNO)‐conjugated on a gold yarn‐dynamos (GY) and embedded in an implantable silk in a microneedle. When subjected to HFMF, conductive GY induces eddy currents that stimulate the release of NO from pGSNO. This process significantly enhances neural stem cell (NSC) synapses' differentiation and growth. The combined strategy of using NO and electrical stimulation to inhibit inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury is demonstrated in vivo. Abstract Endogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and electrical stimulation in clinical settings can be challenging due to NO's short half‐life and the invasive electrodes required for electrical stimulation. Additionally, there is a lack of tools to spatiotemporally control gas release and electrical stimulation. To address these issues, an “electromagnetic messenger” approach that employs on‐demand high‐frequency magnetic field (HFMF) to trigger NO release and electrical stimulation for restoring brain function in cases of traumatic brain injury is introduced. The system comprises a NO donor (poly(S‐nitrosoglutathione), pGSNO)‐conjugated on a gold yarn‐dynamos (GY) and embedded in an implantable silk in a microneedle. When subjected to HFMF, conductive GY induces eddy currents that stimulate the release of NO from pGSNO. This process significantly enhances neural stem cell (NSC) synapses' differentiation and growth. The combined strategy of using NO and electrical stimulation to inhibit inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury is demonstrated in vivo. Endogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and electrical stimulation in clinical settings can be challenging due to NO's short half‐life and the invasive electrodes required for electrical stimulation. Additionally, there is a lack of tools to spatiotemporally control gas release and electrical stimulation. To address these issues, an “electromagnetic messenger” approach that employs on‐demand high‐frequency magnetic field (HFMF) to trigger NO release and electrical stimulation for restoring brain function in cases of traumatic brain injury is introduced. The system comprises a NO donor (poly(S‐nitrosoglutathione), pGSNO)‐conjugated on a gold yarn‐dynamos (GY) and embedded in an implantable silk in a microneedle. When subjected to HFMF, conductive GY induces eddy currents that stimulate the release of NO from pGSNO. This process significantly enhances neural stem cell (NSC) synapses' differentiation and growth. The combined strategy of using NO and electrical stimulation to inhibit inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury is demonstrated in vivo. An “electromagnetic messenger” approach utilizing high‐frequency magnetic fields (HFMF) to trigger nitric oxide (NO) release and electrical stimulation is developed for restoring brain function in traumatic brain injury. Upon exposure to HFMF, in vivo experiments demonstrated the combined strategy's effectiveness in inhibiting inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury. |
Author | Hsu, Ru‐Siou Zhao, Wei‐Jie Chiou, Shih‐Hwa Lee, I‐Chi Hu, Shang‐Hsiu Lin, Ya‐Hui Liu, Hsiu‐Ching Chou, Tsu‐Chin Lu, Tsai‐Te Liao, Lun‐De Chiang, Min‐Ren Chu, Li‐An |
Author_xml | – sequence: 1 givenname: Min‐Ren surname: Chiang fullname: Chiang, Min‐Ren organization: National Tsing Hua University – sequence: 2 givenname: Ya‐Hui surname: Lin fullname: Lin, Ya‐Hui organization: National Tsing Hua University – sequence: 3 givenname: Wei‐Jie surname: Zhao fullname: Zhao, Wei‐Jie organization: National Tsing Hua University – sequence: 4 givenname: Hsiu‐Ching surname: Liu fullname: Liu, Hsiu‐Ching organization: National Tsing Hua University – sequence: 5 givenname: Ru‐Siou surname: Hsu fullname: Hsu, Ru‐Siou organization: Stanford University – sequence: 6 givenname: Tsu‐Chin surname: Chou fullname: Chou, Tsu‐Chin organization: National Tsing Hua University – sequence: 7 givenname: Tsai‐Te surname: Lu fullname: Lu, Tsai‐Te organization: Chung Yuan Christian University – sequence: 8 givenname: I‐Chi surname: Lee fullname: Lee, I‐Chi organization: National Tsing Hua University – sequence: 9 givenname: Lun‐De surname: Liao fullname: Liao, Lun‐De organization: National Health Research Institutes – sequence: 10 givenname: Shih‐Hwa surname: Chiou fullname: Chiou, Shih‐Hwa organization: Taipei Veterans General Hospital – sequence: 11 givenname: Li‐An surname: Chu fullname: Chu, Li‐An email: lachu@mx.nthu.edu.tw organization: National Tsing Hua University – sequence: 12 givenname: Shang‐Hsiu orcidid: 0000-0002-8965-3918 surname: Hu fullname: Hu, Shang‐Hsiu email: shhu@mx.nthu.edu.tw organization: National Tsing Hua University |
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Title | In Situ Forming of Nitric Oxide and Electric Stimulus for Nerve Therapy by Wireless Chargeable Gold Yarn‐Dynamos |
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