Acute lymphocytic leukemia in adolescence with multiple osteolytic lesions and hypercalcemia mediated by lymphoblast-producing parathyroid hormone-related peptide: A case report and review of the literature

• Published in: Pediatric Blood & Cancer Vol. 45; no. 3; pp. 333 - 339
• Main Authors: Shimonodan, Hidemi, Nagayama, Jun, Nagatoshi, Yoshihisa, Hatanaka, Michiki, Takada, Akiko, Iguchi, Haruo, Oda, Yoshinao, Okamura, Jun
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2005; Wiley
• Subjects: acute lymphocytic leukemia; Adolescent; Biological and medical sciences; childhood and adolescence; Fatal Outcome; Female; General aspects; Humans; hypercalcemia; Hypercalcemia - blood; Hypercalcemia - etiology; Medical sciences; multiple osteolysis; Osteolysis - blood; Osteolysis - etiology; parathyroid hormone-related peptide; Parathyroid Hormone-Related Protein - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications; Recurrence; Tumors; Human; Pediatrics; Hydroelectrolytic balance disorder; Calcium; Acute; Malignant hemopathy; Lymphoblast; Osteolysis; Inorganic element; Case study; Hypercalcemia; Metabolic disorder; Cancerology; parathyroid hormone-related peptide; Lymphoproliferative syndrome; Parathyroid hormone related peptide; multiple osteolysis; Acute lymphocytic leukemia; Lesion; childhood and adolescence; Child; Bibliographic review

Background Osteopathy is one of the common initial symptoms of acute lymphocytic leukemia (ALL) in children and adolescents, but multiple osteolysis accompanied by hypercalcemia is rarely observed. Procedure We treated a 14‐year‐old female who had multiple osteolytic lesions and hypercalcemia at ini...