Overexpression of estrogen receptor-α in human papillary thyroid carcinomas studied by laser-capture microdissection and molecular biology

• Published in: Cancer science Vol. 102; no. 10; pp. 1921 - 1927
• Main Authors: Di Vito, Maura, De Santis, Elena, Perrone, Giulietta Anna, Mari, Emanuela, Giordano, Maria Chiara, De Antoni, Enrico, Coppola, Luigi, Fadda, Guido, Tafani, Marco, Carpi, Angelo, Russo, Matteo A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2011; Blackwell
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers, Tumor - biosynthesis; Biomarkers, Tumor - genetics; Biopsy, Fine-Needle; Carcinoma; Carcinoma, Papillary - genetics; Carcinoma, Papillary - metabolism; Carcinoma, Papillary - pathology; Cell Line, Tumor; Endocrinopathies; Estrogen Receptor alpha - biosynthesis; Estrogen Receptor alpha - genetics; Estrogen Receptor alpha - metabolism; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Laser Capture Microdissection; Malignant tumors; Medical sciences; Middle Aged; Neoplastic Stem Cells - metabolism; Protein Isoforms - biosynthesis; Protein Isoforms - genetics; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Thyroid Cancer, Papillary; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology; Thyroid. Thyroid axis (diseases); Tumors; Endocrinopathy; Human; Microdissection; Thyroid diseases; Gene overexpression; Malignant tumor; Capture; Estrogen receptor α; Cancerology; Laser; Molecular biology; Papillary thyroid carcinoma; Cancer

The expression pattern of estrogen receptor (ER) isoforms in normal and tumor thyroid tissues is still controversial and poor defined, therefore, a more detailed study of the distribution of these molecules is needed. Most discrepancies might be due to the methods utilized. We studied the expression...