Enriching and Smart Releasing Curcumin via Phenylboronic Acid‐Anchored Bioinspired Hydrogel for Diabetic Wound Healing
Diabetic wounds suffer from bacterial infections, reactive oxygen species, and inflammatory reactions. Curcumin (Cur) is a natural diketone with antibacterial, anti‐inflammatory, antioxidant activities, but poor water solubility and toxicity at high local concentration. Herein, inspired by the oxyge...
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Published in | Advanced NanoBiomed Research (Online) Vol. 3; no. 5 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Singapore
John Wiley & Sons, Inc
01.05.2023
Wiley-VCH |
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Abstract | Diabetic wounds suffer from bacterial infections, reactive oxygen species, and inflammatory reactions. Curcumin (Cur) is a natural diketone with antibacterial, anti‐inflammatory, antioxidant activities, but poor water solubility and toxicity at high local concentration. Herein, inspired by the oxygen transport process of red blood cells via the dynamic interaction of hemoglobin and oxygen, phenylboronic acid (PBA)‐anchored hydrogel (GOHA‐PBA) is utilized to achieve active enrichment and smart release of Cur, which can reverse the inflammatory microenvironment and promote wound healing. First, PBA‐modified gelatin (Gel‐PBA) and oxidized hyaluronic acid (OHA) crosslink and form GOHA‐PBA by borate ester reaction and Schiff base reaction. GOHA‐PBA possesses excellent curcumin loading efficiency with 130 000 times than that in water and forms Cur‐laden GOHA‐PBA (GOHA‐Cur). GOHA‐Cur has injectability, self‐healing, and self‐adaptive properties, which are conducive to surgical procedure. GOHA‐Cur owns reversible adhesion properties, facilitating it be peeled off and remove harmful substances, including excess glucose, acids, bacteria, and ROS at the wounds. GOHA‐Cur can pH and glucose responsively release Cur; hence, it shows excellent antibacterial, antioxidant, anti‐inflammatory effects in vitro. Animal experiments show that GOHA‐Cur can inhibit inflammation and promote wound regeneration. This study can provide a valuable concept for Cur delivery and diabetic wound healing.
Inspired by the oxygen transport process of red blood cells, active enrichment and smart release of curcumin via dynamic crosslinked hydrogel that hangs PBAs are realized. The hydrogel has excellent curcumin loading efficiency, injectability, and reversible adhesion properties. Meanwhile, the hydrogel can responsively release curcumin according to the pathological environment and eventually shows excellent antibacterial, antioxidant, anti‐inflammatory effects. |
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AbstractList | Diabetic wounds suffer from bacterial infections, reactive oxygen species, and inflammatory reactions. Curcumin (Cur) is a natural diketone with antibacterial, anti‐inflammatory, antioxidant activities, but poor water solubility and toxicity at high local concentration. Herein, inspired by the oxygen transport process of red blood cells via the dynamic interaction of hemoglobin and oxygen, phenylboronic acid (PBA)‐anchored hydrogel (GOHA‐PBA) is utilized to achieve active enrichment and smart release of Cur, which can reverse the inflammatory microenvironment and promote wound healing. First, PBA‐modified gelatin (Gel‐PBA) and oxidized hyaluronic acid (OHA) crosslink and form GOHA‐PBA by borate ester reaction and Schiff base reaction. GOHA‐PBA possesses excellent curcumin loading efficiency with 130 000 times than that in water and forms Cur‐laden GOHA‐PBA (GOHA‐Cur). GOHA‐Cur has injectability, self‐healing, and self‐adaptive properties, which are conducive to surgical procedure. GOHA‐Cur owns reversible adhesion properties, facilitating it be peeled off and remove harmful substances, including excess glucose, acids, bacteria, and ROS at the wounds. GOHA‐Cur can pH and glucose responsively release Cur; hence, it shows excellent antibacterial, antioxidant, anti‐inflammatory effects in vitro. Animal experiments show that GOHA‐Cur can inhibit inflammation and promote wound regeneration. This study can provide a valuable concept for Cur delivery and diabetic wound healing. Diabetic wounds suffer from bacterial infections, reactive oxygen species, and inflammatory reactions. Curcumin (Cur) is a natural diketone with antibacterial, anti‐inflammatory, antioxidant activities, but poor water solubility and toxicity at high local concentration. Herein, inspired by the oxygen transport process of red blood cells via the dynamic interaction of hemoglobin and oxygen, phenylboronic acid (PBA)‐anchored hydrogel (GOHA‐PBA) is utilized to achieve active enrichment and smart release of Cur, which can reverse the inflammatory microenvironment and promote wound healing. First, PBA‐modified gelatin (Gel‐PBA) and oxidized hyaluronic acid (OHA) crosslink and form GOHA‐PBA by borate ester reaction and Schiff base reaction. GOHA‐PBA possesses excellent curcumin loading efficiency with 130 000 times than that in water and forms Cur‐laden GOHA‐PBA (GOHA‐Cur). GOHA‐Cur has injectability, self‐healing, and self‐adaptive properties, which are conducive to surgical procedure. GOHA‐Cur owns reversible adhesion properties, facilitating it be peeled off and remove harmful substances, including excess glucose, acids, bacteria, and ROS at the wounds. GOHA‐Cur can pH and glucose responsively release Cur; hence, it shows excellent antibacterial, antioxidant, anti‐inflammatory effects in vitro. Animal experiments show that GOHA‐Cur can inhibit inflammation and promote wound regeneration. This study can provide a valuable concept for Cur delivery and diabetic wound healing. Inspired by the oxygen transport process of red blood cells, active enrichment and smart release of curcumin via dynamic crosslinked hydrogel that hangs PBAs are realized. The hydrogel has excellent curcumin loading efficiency, injectability, and reversible adhesion properties. Meanwhile, the hydrogel can responsively release curcumin according to the pathological environment and eventually shows excellent antibacterial, antioxidant, anti‐inflammatory effects. |
Author | Cao, Xiaodong Liu, YuWei Zhao, Bangjiao Feng, Qi Zhu, Shuangli Li, Maocai Zhu, Jiayi Luo, Huitong Wang, Hao |
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SubjectTerms | Antiinfectives and antibacterials Antioxidants Bacteria Blood levels boronate ester reactions Curcumin Diabetes Diabetes mellitus diabetic wound healing Diketones Erythrocytes Fourier transforms Gelatin Glucose Hemoglobin Hyaluronic acid Hydrogels Imines Infections Inflammation Nanoparticles Oxygen enrichment Reactive oxygen species Toxicity Ulcers Wound healing Wound infection |
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Title | Enriching and Smart Releasing Curcumin via Phenylboronic Acid‐Anchored Bioinspired Hydrogel for Diabetic Wound Healing |
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