Structural and quantitative evidence of α2–6-sialylated N-glycans as markers of the differentiation potential of human mesenchymal stem cells

• Published in: Glycoconjugate journal Vol. 34; no. 6; pp. 797 - 806
• Main Authors: Hasehira, Kayo, Hirabayashi, Jun, Tateno, Hiroaki
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2017; Springer Nature B.V
• Subjects: Adipose tissue; Biochemistry; Biomarkers; Biomedical and Life Sciences; Cartilage; Chondrocytes; Drug therapy; Fibroblasts; High-performance liquid chromatography; Immune system; Life Sciences; Mass spectroscopy; Mesenchymal stem cells; Mesenchyme; N-glycans; Original; Original Article; Pathology; Pluripotency; Polysaccharides; Skin; Stem cells; Tissues; Transplantation; Mesenchymal stem cell; Differentiation; Sialylation; Glycan; Hydrazinolysis
• ISSN: 0282-0080; 1573-4986; 1573-4986
• DOI: 10.1007/s10719-016-9699-6

Human somatic stem cells such as mesenchymal stem cells (hMSCs) have the capacity to differentiate into mesenchymal tissue lineages and to alter immune regulatory functions. As such, they hold promise for use in stem cell-based therapies. However, no method is currently available to evaluate the act...