Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

• Published in: The journal of clinical endocrinology and metabolism Vol. 101; no. 3; pp. 1044 - 1054
• Main Authors: Cinti, Francesca, Bouchi, Ryotaro, Kim-Muller, Ja Young, Ohmura, Yoshiaki, Sandoval, P. R., Masini, Matilde, Marselli, Lorella, Suleiman, Mara, Ratner, Lloyd E., Marchetti, Piero, Accili, Domenico
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.03.2016; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Aldehyde dehydrogenase; Aldehydes; Beta cells; Cell Dedifferentiation; Dehydrogenases; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - pathology; Forkhead Box Protein O1; Forkhead Transcription Factors - analysis; Glucagon; Glucagon - metabolism; Glucagon-Secreting Cells - physiology; Homeodomain Proteins - analysis; Humans; Immunohistochemistry; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - chemistry; Insulin-Secreting Cells - pathology; Insulin-Secreting Cells - physiology; Microscopy, Electron; Organ donors; Original; Pancreas; Progenitor cells; Somatostatin; Somatostatin - metabolism; Somatostatin-Secreting Cells - physiology; Transcription factors

Context:Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies show that β-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage, and partly converting to other endocrine cell types.Objective:To determine whether similar processes occur in human...