Isoflavones Reduce Arterial Stiffness: A Placebo-Controlled Study in Men and Postmenopausal Women

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 23; no. 6; pp. 1066 - 1071
• Main Authors: Teede, Helena J., McGrath, Barry P., DeSilva, Lakmini, Cehun, Marja, Fassoulakis, Andriana, Nestel, Paul J.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.06.2003; Hagerstown, MD Lippincott
• Subjects: Aged; Arm - blood supply; Biological and medical sciences; Blood Pressure - drug effects; Cardiovascular system; Cross-Over Studies; Diet; Double-Blind Method; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Female; Genistein - pharmacology; Humans; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Isoflavones - pharmacology; Male; Medical sciences; Middle Aged; Phytoestrogens; Plant Preparations - pharmacology; Postmenopause; Reference Values; Regional Blood Flow; Trifolium - chemistry; Vascular Cell Adhesion Molecule-1 - blood; Vascular Resistance - drug effects; Vasodilation; Human; arterial stiffness; endothelial function; blood pressure; vascular cellular adhesion molecule-1; isoflavones; Male; Compliance(volume pressure); Isoflavone derivatives; Artery; Diet; Postmenopause; Female; Stiffness; Hemodynamics

OBJECTIVE—This study was undertaken to address the vascular effects of isolated isoflavones as potential contributors to their cardioprotective properties, focusing on biochanin and formononetin. METHODS AND RESULTS—In a randomized, double-blind trial, 80 healthy subjects, 46 men and 34 women, 45 to...