Glutathione content as a potential mediator of the vulnerability of cultured fetal cortical neurons to ethanol-induced apoptosis

• Published in: Journal of neuroscience research Vol. 86; no. 5; pp. 1064 - 1076
• Main Authors: Maffi, Shivani Kaushal, Rathinam, Mary Latha, Cherian, Priscilla P., Pate, William, Hamby-Mason, Rhoda, Schenker, Steven, Henderson, George I.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2008
• Subjects: alcohol; Alcohol-Induced Disorders, Nervous System - metabolism; Alcohol-Induced Disorders, Nervous System - physiopathology; Aldehydes - metabolism; Animals; apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Caspase 3 - metabolism; Cells, Cultured; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cerebral Cortex - physiopathology; Drug Resistance - physiology; Ethanol - toxicity; FASD; Female; Flow Cytometry; Gene Expression Regulation, Developmental - drug effects; glutathione; Glutathione - metabolism; neuron; Neurons - classification; Neurons - drug effects; Neurons - metabolism; oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases - metabolism; Pregnancy; Rats

Ethanol ingestion during pregnancy elicits damage to the developing brain, some of which appears to result from enhanced apoptotic death of neurons. A consistent characteristic of this phenomenon is a highly differing sensitivity to ethanol within specific neuron populations. One possible explanatio...