MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

• Published in: Nature reviews. Genetics Vol. 13; no. 4; pp. 271 - 282
• Main Author: Pasquinelli, Amy E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2012; Nature Publishing Group
• Subjects: 631/208/200; Agriculture; Animal Genetics and Genomics; Animals; Binding Sites; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Biosynthesis; Cancer Research; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation; Gene Function; Genes; Genetics of eukaryotes. Biological and molecular evolution; Genomes; Human Genetics; MicroRNA; MicroRNAs; MicroRNAs - physiology; Physiological aspects; Proteins; review-article; RNA Stability; RNA, Messenger - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; RNA-Induced Silencing Complex - genetics; RNA-Induced Silencing Complex - metabolism; United States; United States > US; California; Gene silencing; Regulation(control); RNA interference; Review; Recognition; Micro RNA

Key Points MicroRNAs (miRNAs) function as 21–24-nucleotide-long guides that regulate the expression of mRNAs containing complementary sequences. Although plant miRNAs typically base-pair perfectly to target sites, animal miRNAs form imperfect duplexes with target sequences, complicating the ability...