Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 3 approved]

Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, and is associated with hyperinflammation and cytokine storm. The...

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Published inF1000 research Vol. 10; p. 273
Main Authors K, Nithin K, Patil, Prakash, Bhandary, Satheesh Kumar, Haridas, Vikram, N, Suchetha Kumari, E, Sarathkumar, Shetty, Praveenkumar
Format Journal Article
LanguageEnglish
Published London Faculty of 1000 Ltd 2021
F1000 Research Limited
F1000 Research Ltd
Subjects
Anti-inflammatory agents
Butyric acid
Coronaviruses
Corticosteroids
COVID-19
Cytokine storm
Dexamethasone
Fatty acids
Immune response
Inflammation
Intestinal microflora
Kinases
Microbiota
Micronutrients
Oxidative stress
Probiotics
Respiratory distress syndrome
Review
Severe acute respiratory syndrome coronavirus 2
Steroids
Viral infections
Vitamin E
Gut microbiota
Hyperinflammation
Probiotics
Dexamethasone
CoVID-19
Cytokine storm
Butyrate
Butyric acid
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Abstract Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, and is associated with hyperinflammation and cytokine storm. The broad spectrum immunosuppressant corticosteroid, dexamethasone, is being used to manage the cytokine storm and hyperinflammation in CoVID-19 patients. However, the extensive use of corticosteroids leads to serious adverse events and disruption of the gut-lung axis. Various micronutrients and probiotic supplementations are known to aid in the reduction of hyperinflammation and restoration of gut microbiota. The attenuation of the deleterious immune response and hyperinflammation could be mediated by short chain fatty acids produced by the gut microbiota. Butyric acid, the most extensively studied short chain fatty acid, is known for its anti-inflammatory properties. Additionally, butyric acid has been shown to ameliorate hyperinflammation and reduce oxidative stress in various pathologies, including respiratory viral infections. In this review, the potential anti-inflammatory effects of butyric acid that aid in cytokine storm depletion, and its usefulness in effective management of critical illness related to CoVID-19 have been discussed.
AbstractList Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, and is associated with hyperinflammation and cytokine storm. The broad spectrum immunosuppressant corticosteroid, dexamethasone, is being used to manage the cytokine storm and hyperinflammation in CoVID-19 patients. However, the extensive use of corticosteroids leads to serious adverse events and disruption of the gut-lung axis. Various micronutrients and probiotic supplementations are known to aid in the reduction of hyperinflammation and restoration of gut microbiota. The attenuation of the deleterious immune response and hyperinflammation could be mediated by short chain fatty acids produced by the gut microbiota. Butyric acid, the most extensively studied short chain fatty acid, is known for its anti-inflammatory properties. Additionally, butyric acid has been shown to ameliorate hyperinflammation and reduce oxidative stress in various pathologies, including respiratory viral infections. In this review, the potential anti-inflammatory effects of butyric acid that aid in cytokine storm depletion, and its usefulness in effective management of critical illness related to CoVID-19 have been discussed.
Author Shetty, Praveenkumar
E, Sarathkumar
Haridas, Vikram
Patil, Prakash
K, Nithin K
N, Suchetha Kumari
Bhandary, Satheesh Kumar
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  surname: Bhandary
  fullname: Bhandary, Satheesh Kumar
  organization: Department of ENT, Justice K S Hegde Charitable Hospital, Nitte (Deemed to be University), Mangaluru, Karnataka, 575018, India
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  surname: Shetty
  fullname: Shetty, Praveenkumar
  email: praveenkumarshetty@nitte.edu.in
  organization: Department of Biochemistry/Central Research Laboratory, K S Hegde Medical Academy, Nitte (Deemed to be University), Mangaluru, Karnataka, 575018, India
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ContentType Journal Article
Copyright Copyright: © 2021 K NK et al.
Copyright: © 2021 K NK et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Keywords Gut microbiota
Hyperinflammation
Probiotics
Dexamethasone
CoVID-19
Cytokine storm
Butyrate
Butyric acid
Language English
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Snippet Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19...
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SubjectTerms Anti-inflammatory agents
Butyric acid
Coronaviruses
Corticosteroids
COVID-19
Cytokine storm
Dexamethasone
Fatty acids
Immune response
Inflammation
Intestinal microflora
Kinases
Microbiota
Micronutrients
Oxidative stress
Probiotics
Respiratory distress syndrome
Review
Severe acute respiratory syndrome coronavirus 2
Steroids
Viral infections
Vitamin E
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Title Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 3 approved]
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Volume 10
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