Degeneration of nigrostriatal pathway in patients with middle cerebral infarct: A diffusion tensor imaging study
The nigrostriatal tract (NST) is a dopaminergic pathway that runs from the substantia nigra pars compacta in the midbrain to the dorsal striatum (caudate nucleus and putamen) and regulates voluntary movement via the basal ganglia motor loops. However, it is unclear whether the effects of ischemic st...
Saved in:
| Published in | Medicine (Baltimore) Vol. 102; no. 14; p. e33370 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Lippincott Williams & Wilkins
07.04.2023
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The nigrostriatal tract (NST) is a dopaminergic pathway that runs from the substantia nigra pars compacta in the midbrain to the dorsal striatum (caudate nucleus and putamen) and regulates voluntary movement via the basal ganglia motor loops. However, it is unclear whether the effects of ischemic stroke, such as middle cerebral artery (MCA) infarction, are associated with changes in the NST. Thirty MCA infarct patients and 40 healthy subjects with no history of psychiatric or neurological disorders were enrolled in the present study. Diffusion tensor tractography was used to investigate injury to the ipsilesional and contralesional NST in MCA infarct patients compared to the normal human brain. There was a significant difference in the mean fractional anisotropy and tract volume values of the NST between the patient and control groups (
P
< .05). post hoc analysis revealed that the mean fractional anisotropy and tract volume from the ipsilesional NST showed a significant difference compared with those of the contralesional NST and control groups (
P
< .05). MCA infarction can lead to damage to the ipsilesional NST, which can impair one’s ability to stop unwanted muscular contractions or voluntary movement. |
|---|---|
| AbstractList | The nigrostriatal tract (NST) is a dopaminergic pathway that runs from the substantia nigra pars compacta in the midbrain to the dorsal striatum (caudate nucleus and putamen) and regulates voluntary movement via the basal ganglia motor loops. However, it is unclear whether the effects of ischemic stroke, such as middle cerebral artery (MCA) infarction, are associated with changes in the NST. Thirty MCA infarct patients and 40 healthy subjects with no history of psychiatric or neurological disorders were enrolled in the present study. Diffusion tensor tractography was used to investigate injury to the ipsilesional and contralesional NST in MCA infarct patients compared to the normal human brain. There was a significant difference in the mean fractional anisotropy and tract volume values of the NST between the patient and control groups (
P
< .05). post hoc analysis revealed that the mean fractional anisotropy and tract volume from the ipsilesional NST showed a significant difference compared with those of the contralesional NST and control groups (
P
< .05). MCA infarction can lead to damage to the ipsilesional NST, which can impair one’s ability to stop unwanted muscular contractions or voluntary movement. The nigrostriatal tract (NST) is a dopaminergic pathway that runs from the substantia nigra pars compacta in the midbrain to the dorsal striatum (caudate nucleus and putamen) and regulates voluntary movement via the basal ganglia motor loops. However, it is unclear whether the effects of ischemic stroke, such as middle cerebral artery (MCA) infarction, are associated with changes in the NST. Thirty MCA infarct patients and 40 healthy subjects with no history of psychiatric or neurological disorders were enrolled in the present study. Diffusion tensor tractography was used to investigate injury to the ipsilesional and contralesional NST in MCA infarct patients compared to the normal human brain. There was a significant difference in the mean fractional anisotropy and tract volume values of the NST between the patient and control groups (P < .05). post hoc analysis revealed that the mean fractional anisotropy and tract volume from the ipsilesional NST showed a significant difference compared with those of the contralesional NST and control groups (P < .05). MCA infarction can lead to damage to the ipsilesional NST, which can impair one's ability to stop unwanted muscular contractions or voluntary movement.The nigrostriatal tract (NST) is a dopaminergic pathway that runs from the substantia nigra pars compacta in the midbrain to the dorsal striatum (caudate nucleus and putamen) and regulates voluntary movement via the basal ganglia motor loops. However, it is unclear whether the effects of ischemic stroke, such as middle cerebral artery (MCA) infarction, are associated with changes in the NST. Thirty MCA infarct patients and 40 healthy subjects with no history of psychiatric or neurological disorders were enrolled in the present study. Diffusion tensor tractography was used to investigate injury to the ipsilesional and contralesional NST in MCA infarct patients compared to the normal human brain. There was a significant difference in the mean fractional anisotropy and tract volume values of the NST between the patient and control groups (P < .05). post hoc analysis revealed that the mean fractional anisotropy and tract volume from the ipsilesional NST showed a significant difference compared with those of the contralesional NST and control groups (P < .05). MCA infarction can lead to damage to the ipsilesional NST, which can impair one's ability to stop unwanted muscular contractions or voluntary movement. The nigrostriatal tract (NST) is a dopaminergic pathway that runs from the substantia nigra pars compacta in the midbrain to the dorsal striatum (caudate nucleus and putamen) and regulates voluntary movement via the basal ganglia motor loops. However, it is unclear whether the effects of ischemic stroke, such as middle cerebral artery (MCA) infarction, are associated with changes in the NST. Thirty MCA infarct patients and 40 healthy subjects with no history of psychiatric or neurological disorders were enrolled in the present study. Diffusion tensor tractography was used to investigate injury to the ipsilesional and contralesional NST in MCA infarct patients compared to the normal human brain. There was a significant difference in the mean fractional anisotropy and tract volume values of the NST between the patient and control groups ( P < .05). post hoc analysis revealed that the mean fractional anisotropy and tract volume from the ipsilesional NST showed a significant difference compared with those of the contralesional NST and control groups ( P < .05). MCA infarction can lead to damage to the ipsilesional NST, which can impair one’s ability to stop unwanted muscular contractions or voluntary movement. |
| Author | Koo, Dong Kyun Seo, Jeong Pyo |
| AuthorAffiliation | Department of Physical Therapy, College of Health Sciences, Dankook University, Cheonan, Chungnam, Republic of Korea Department of Public Health Sciences, Graduate School, Dankook University, Cheonan, Republic of Korea |
| AuthorAffiliation_xml | – name: Department of Physical Therapy, College of Health Sciences, Dankook University, Cheonan, Chungnam, Republic of Korea – name: Department of Public Health Sciences, Graduate School, Dankook University, Cheonan, Republic of Korea |
| Author_xml | – sequence: 1 givenname: Jeong Pyo surname: Seo fullname: Seo, Jeong Pyo organization: Department of Physical Therapy, College of Health Sciences, Dankook University, Cheonan, Chungnam, Republic of Korea – sequence: 2 givenname: Dong Kyun surname: Koo fullname: Koo, Dong Kyun organization: Department of Public Health Sciences, Graduate School, Dankook University, Cheonan, Republic of Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37026940$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Uclu1DAYtlARnRaeAAn5yCXFaxxzQVWHTWrFBc6W4yUxZJzBdjqat8fTaVl6wBdbv79N338GTuIcHQAvMbrASIo3N-sL9OdQSgV6AlaY07bhsmUnYIUQ4Y2Qgp2Cs5y_I4SpIOwZOK1Q0kqGVmC7doOLLukS5ghnD2MY0pxLCrroCW51GXd6D0M8PIOLJcNdKCPcBGsnB41Lrk8VGKLXyZS38BLa4P2SD3LFxTwnGDZ6CHGAuSx2_xw89XrK7sX9fQ6-fXj_9epTc_3l4-ery-vGMI5xY6X23hvZWyx7wrWj3jLZaWyNdcx0qCdtjzTvmECW085z3ptOdoQQjdo6OQfvjrrbpd84a2r0mlNtU02T9mrWQf37E8OohvlWYYQOKrIqvL5XSPPPxeWiNiEbN006unnJigjZiboIiSr01d9mv10eeq4AeQSYWm5OzisTyl3n1TtM1VQddqpu1urxTiuXPuI-yP-fxY6s3TwVl_KPadm5pEanpzLewbmQpCGIUMSQQE2dMEx_AQ-ltd0 |
| CitedBy_id | crossref_primary_10_32604_biocell_2024_053597 crossref_primary_10_3390_brainsci13060927 |
| Cites_doi | 10.1097/01.rmr.0000168069.12985.15 10.1371/journal.pone.0084825 10.1038/srep17283 10.1016/j.neuroimage.2006.09.018 10.1002/jmri.21087 10.1016/j.neuroimage.2004.07.051 10.2463/mrms.3.11 10.1002/mds.26251 10.1016/j.neubiorev.2010.02.001 10.1016/j.neuron.2015.05.041 10.1016/S0079-6123(03)43043-4 10.1038/nature09159 10.1161/01.STR.23.3.328 10.1016/j.neuron.2015.02.027 10.1016/j.neuron.2010.07.002 10.1016/j.parkreldis.2018.02.046 10.1016/j.neulet.2013.02.058 10.2463/mrms.8.165 10.1016/j.neuroimage.2008.03.021 10.1016/j.neubiorev.2006.06.002 10.1007/BF00684925 10.1093/brain/awh355 10.1038/nrn2735 10.1007/s12031-007-0029-0 10.1148/radiology.204.1.9205256 10.1038/nn1075 |
| ContentType | Journal Article |
| Copyright | Lippincott Williams & Wilkins Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. 2023 |
| Copyright_xml | – notice: Lippincott Williams & Wilkins – notice: Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. – notice: Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. 2023 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1097/MD.0000000000033370 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1536-5964 |
| EndPage | e33370 |
| ExternalDocumentID | PMC10082229 37026940 10_1097_MD_0000000000033370 00005792-202304070-00041 |
| Genre | Journal Article |
| GroupedDBID | --- .-D .XZ .Z2 01R 0R~ 354 40H 4Q1 4Q2 4Q3 5GY 5RE 5VS 71W 77Y 7O~ AAAAV AAGIX AAHPQ AAIQE AAMOA AAQKA AARTV AASCR AAWTL AAXQO AAYEP ABASU ABBUW ABCQX ABDIG ABFRF ABOCM ABVCZ ABXVJ ABZAD ABZZY ACDDN ACEWG ACGFO ACGFS ACILI ACLDA ACWDW ACWRI ACXJB ACXNZ ACZKN ADGGA ADHPY ADNKB ADPDF AE6 AEFWE AENEX AFBFQ AFDTB AGOPY AHOMT AHQNM AHVBC AIJEX AINUH AJCLO AJIOK AJNWD AJNYG AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC BQLVK CS3 DIWNM DU5 E.X EBS EEVPB ERAAH EX3 F2K F2L F2M F2N F5P FCALG FD6 FIJ FL- GNXGY GQDEL GROUPED_DOAJ H0~ HLJTE HYE HZ~ H~9 IKREB IKYAY IN~ IPNFZ JK3 JK8 K8S KD2 KMI KQ8 L-C N9A N~7 N~B O9- OAG OAH OB2 OHH OK1 OL1 OLB OLG OLH OLU OLV OLY OLZ OPUJH OUVQU OVD OVDNE OVEED OVIDH OVLEI OWV OWW OWZ OXXIT P2P RIG RLZ RPM RXW S4R S4S TAF TEORI TSPGW UNMZH V2I VVN W3M WOQ WOW X3V X3W XYM YFH YOC ZFV ZY1 AAYXX CITATION 8L- ACIJW AWKKM CGR CUY CVF ECM EIF NPM ODA 7X8 ADSXY 5PM |
| ID | FETCH-LOGICAL-c4511-d9afffc9bd19b25ae3fd498a1dcde4c80b26b0a58470d538f55bc898222a06d53 |
| ISSN | 0025-7974 1536-5964 |
| IngestDate | Thu Aug 21 18:38:16 EDT 2025 Tue Aug 05 09:58:16 EDT 2025 Wed Feb 19 02:23:21 EST 2025 Thu Apr 24 22:51:12 EDT 2025 Tue Jul 01 05:05:52 EDT 2025 Fri May 16 04:11:46 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 14 |
| Language | English |
| License | Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c4511-d9afffc9bd19b25ae3fd498a1dcde4c80b26b0a58470d538f55bc898222a06d53 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-2500-6842 |
| OpenAccessLink | http://dx.doi.org/10.1097/MD.0000000000033370 |
| PMID | 37026940 |
| PQID | 2798709790 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_10082229 proquest_miscellaneous_2798709790 pubmed_primary_37026940 crossref_citationtrail_10_1097_MD_0000000000033370 crossref_primary_10_1097_MD_0000000000033370 wolterskluwer_health_00005792-202304070-00041 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-April-07 |
| PublicationDateYYYYMMDD | 2023-04-07 |
| PublicationDate_xml | – month: 04 year: 2023 text: 2023-April-07 day: 07 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hagerstown, MD |
| PublicationTitle | Medicine (Baltimore) |
| PublicationTitleAlternate | Medicine (Baltimore) |
| PublicationYear | 2023 |
| Publisher | Lippincott Williams & Wilkins |
| Publisher_xml | – name: Lippincott Williams & Wilkins |
| References | Murphy (R2-20250504) 2009; 10 Kravitz (R9-20250504) 2010; 466 Nambu (R10-20250504) 2004; 143 Forno (R27-20250504) 1983; 62 Assaf (R21-20250504) 2008; 34 Moskowitz (R4-20250504) 2010; 67 Tan (R13-20250504) 2015; 5 Ikemoto (R8-20250504) 2010; 35 Nakane (R30-20250504) 1992; 23 Huang (R29-20250504) 2017; 7 Murphy (R1-20250504) 2020; 2021 Inglese (R25-20250504) 2004; 15 Buss (R28-20250504) 2005; 128 Kravitz (R11-20250504) 2012; 27 Behrens (R16-20250504) 2003; 6 Smith (R15-20250504) 2004; 23 Kunimatsu (R17-20250504) 2004; 3 Song (R19-20250504) 2014; 9 Yamada (R31-20250504) 2009; 8 Behrens (R18-20250504) 2007; 34 Jang (R20-20250504) 2013; 543 Zhang (R12-20250504) 2015; 30 Ogawa (R26-20250504) 1997; 204 Pagani (R23-20250504) 2008; 41 Sullivan (R24-20250504) 2006; 30 Bath (R5-20250504) 2000 Corbetta (R7-20250504) 2015; 85 George (R3-20250504) 2015; 87 Andica (R14-20250504) 2018; 51 Neil (R22-20250504) 2008; 27 |
| References_xml | – volume: 15 start-page: 355 year: 2004 ident: R25-20250504 article-title: Quantitative MRI: hidden age-related changes in brain tissue. publication-title: Top Magn Reson Imaging doi: 10.1097/01.rmr.0000168069.12985.15 – volume: 9 start-page: e84825 year: 2014 ident: R19-20250504 article-title: Tractography of the brainstem in major depressive disorder using diffusion tensor imaging. publication-title: PLoS One doi: 10.1371/journal.pone.0084825 – volume: 5 start-page: 1 year: 2015 ident: R13-20250504 article-title: Deterministic tractography of the nigrostriatal-nigropallidal pathway in Parkinson’s disease. publication-title: Sci Rep doi: 10.1038/srep17283 – volume: 27 start-page: 167 year: 2012 ident: R11-20250504 article-title: Striatal mechanisms underlying movement, reinforcement, and punishment. publication-title: Physiology (Bethesda) – volume: 34 start-page: 144 year: 2007 ident: R18-20250504 article-title: Probabilistic diffusion tractography with multiple fibre orientations: what can we gain? publication-title: Neuroimage doi: 10.1016/j.neuroimage.2006.09.018 – volume: 27 start-page: 1 year: 2008 ident: R22-20250504 article-title: Diffusion imaging concepts for clinicians. publication-title: J Magn Reson Imaging doi: 10.1002/jmri.21087 – volume: 23 start-page: S208 year: 2004 ident: R15-20250504 article-title: Advances in functional and structural MR image analysis and implementation as FSL. publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.07.051 – volume: 3 start-page: 11 year: 2004 ident: R17-20250504 article-title: The optimal trackability threshold of fractional anisotropy for diffusion tensor tractography of the corticospinal tract. publication-title: Magn Reson Med Sci doi: 10.2463/mrms.3.11 – volume: 30 start-page: 1229 year: 2015 ident: R12-20250504 article-title: Diffusion tensor imaging of the nigrostriatal fibers in Parkinson’s disease. publication-title: Mov Disord doi: 10.1002/mds.26251 – volume: 2021 year: 2020 ident: R1-20250504 article-title: Mortality in the United States. – volume: 35 start-page: 129 year: 2010 ident: R8-20250504 article-title: Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory. publication-title: Neurosci Biobehav Rev doi: 10.1016/j.neubiorev.2010.02.001 – volume: 87 start-page: 297 year: 2015 ident: R3-20250504 article-title: Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments. publication-title: Neuron doi: 10.1016/j.neuron.2015.05.041 – volume: 143 start-page: 461 year: 2004 ident: R10-20250504 article-title: A new dynamic model of the cortico-basal ganglia loop. publication-title: Prog Brain Res doi: 10.1016/S0079-6123(03)43043-4 – volume: 466 start-page: 622 year: 2010 ident: R9-20250504 article-title: Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. publication-title: Nature doi: 10.1038/nature09159 – volume: 23 start-page: 328 year: 1992 ident: R30-20250504 article-title: Degeneration of the ipsilateral substantia nigra following cerebral infarction in the striatum. publication-title: Stroke doi: 10.1161/01.STR.23.3.328 – volume: 85 start-page: 927 year: 2015 ident: R7-20250504 article-title: Common behavioral clusters and subcortical anatomy in stroke. publication-title: Neuron doi: 10.1016/j.neuron.2015.02.027 – start-page: CD000323 year: 2000 ident: R5-20250504 article-title: Interventions for dysphagia in acute stroke. publication-title: Cochrane Database Syst Rev – volume: 67 start-page: 181 year: 2010 ident: R4-20250504 article-title: The science of stroke: mechanisms in search of treatments. publication-title: Neuron doi: 10.1016/j.neuron.2010.07.002 – volume: 51 start-page: 55 year: 2018 ident: R14-20250504 article-title: Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson’s disease: retrograde degeneration observed by tract-profile analysis. publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2018.02.046 – volume: 543 start-page: 47 year: 2013 ident: R20-20250504 article-title: Cingulum injury in patients with diffuse axonal injury: a diffusion tensor imaging study. publication-title: Neurosci Lett doi: 10.1016/j.neulet.2013.02.058 – volume: 8 start-page: 165 year: 2009 ident: R31-20250504 article-title: MR tractography: a review of its clinical applications. publication-title: Magn Reson Med Sci doi: 10.2463/mrms.8.165 – volume: 41 start-page: 657 year: 2008 ident: R23-20250504 article-title: Voxel-based analysis derived from fractional anisotropy images of white matter volume changes with aging. publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.03.021 – volume: 30 start-page: 749 year: 2006 ident: R24-20250504 article-title: Diffusion tensor imaging and aging. publication-title: Neurosci Biobehav Rev doi: 10.1016/j.neubiorev.2006.06.002 – volume: 62 start-page: 96 year: 1983 ident: R27-20250504 article-title: Reaction of the substantia nigra to massive basal ganglia infarction. publication-title: Acta Neuropathol doi: 10.1007/BF00684925 – volume: 128 start-page: 356 year: 2005 ident: R28-20250504 article-title: Sequential loss of myelin proteins during Wallerian degeneration in the human spinal cord. publication-title: Brain doi: 10.1093/brain/awh355 – volume: 10 start-page: 861 year: 2009 ident: R2-20250504 article-title: Plasticity during stroke recovery: from synapse to behaviour. publication-title: Nat Rev Neurosci doi: 10.1038/nrn2735 – volume: 34 start-page: 51 year: 2008 ident: R21-20250504 article-title: Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. publication-title: J Mol Neurosci doi: 10.1007/s12031-007-0029-0 – volume: 204 start-page: 255 year: 1997 ident: R26-20250504 article-title: Secondary thalamic degeneration after cerebral infarction in the middle cerebral artery distribution: evaluation with MR imaging. publication-title: Radiology doi: 10.1148/radiology.204.1.9205256 – volume: 6 start-page: 750 year: 2003 ident: R16-20250504 article-title: Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. publication-title: Nat Neurosci doi: 10.1038/nn1075 – volume: 7 start-page: 1 year: 2017 ident: R29-20250504 article-title: Stroke triggers nigrostriatal plasticity and increases alcohol consumption in rats. publication-title: Sci Rep |
| SSID | ssj0013724 |
| Score | 2.4135647 |
| Snippet | The nigrostriatal tract (NST) is a dopaminergic pathway that runs from the substantia nigra pars compacta in the midbrain to the dorsal striatum (caudate... |
| SourceID | pubmedcentral proquest pubmed crossref wolterskluwer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | e33370 |
| SubjectTerms | Basal Ganglia Diffusion Tensor Imaging - methods Humans Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - diagnostic imaging Ischemic Stroke - complications Observational Study Putamen |
| Title | Degeneration of nigrostriatal pathway in patients with middle cerebral infarct: A diffusion tensor imaging study |
| URI | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005792-202304070-00041 https://www.ncbi.nlm.nih.gov/pubmed/37026940 https://www.proquest.com/docview/2798709790 https://pubmed.ncbi.nlm.nih.gov/PMC10082229 |
| Volume | 102 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3rb9MwELfKJiEkhHhTHpOR-DYyEqd5mG-DdhpjDyRa1G-R7ThQsSXT1moafz13dpwmtEKDfogqx0ms3C_n8_nud4S84THSpEWhlxcKFihprjwuhPJAE7JcBioWhYnyPY73J4ODaTTt9T61opYWc7mjfq3NK_kfqUIbyBWzZP9Bss1NoQH-g3zhCBKG441kPIQlP7JGO6uvnH3HJA54MqY4YrHhK2Hy-mr21DqV7cw4JbaVvsBdYyTdKADu1kdoKqYs0IW2jbHtGK1-ZgsZLYloXQGoelsejdQP4nQ-szG7jWfhq3XDHmgsZ_Tlump0e1VZ0x2aP18vyrbjgYUmXiXp6MrYi7glId_Ra9qcgvVZG0mDlr7UYRjawiErqtxSBB8NLcOk_TW9u8TZxyfZ3uTwMBuPpuNbZJPBigFU3ubJt9FouNxSSmyFYzdCR0HFk3drHtI1U1bWHqshtHevKgxvuPxpshtaNsr4PrlXLy7orkXKA9LT5UNy28npETlvA4ZWBe0AhtaAobOSOsBQBAy1gKEOMLQGzHu6Sxu4UAsXWsOFGrg8JpO90fjjvleX3PAUEtV5ORdFUSgu84BLFgkdFvmApyLIVa4HKvUli6UvcG_dz2GuLKJIqhQ5IJnwY2h5QjbKqtTPCA25SkPNpI4kskrGUhZMDQLhJ7CEVirtE-becKZqPnosi3KaubiIo2H2p1j65G1z0bmlY_l799dOdBmoTdwLE6WuFpcZSzjMVDzh0OepFWVzQ7gQ87vhTNoRctMBKdm7Z8rZD0PNHpgKCoz3idfBQ2azms0Ao4QzDz8omD8TS-sQPL_BQF-QO8vP8CXZmF8s9CuwiOdyy3iStmrE_wZHhrW2 |
| linkProvider | Ovid |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELfQJgESQnxTPo2E8kQgcT6N1IeqyShjLUjtYDxFtmNv1bak6gcT_z13TlpWJpDIS6L4nIfc2T777n4_Ql7zGGHSosAtjYINSloqlwuhXJgJWSl9FQtjs3xH8eAw3D-KjtpsC6yFweqzxewt3uw8jQ_Ih4Mbw0l3f-yM8m_jbuX0x_3ud-dL70Nuz6kxS8LJuvUPs3R6I5t_FSWcuUgODmaaNNXTsEvajSOWwADe_fw1z7Pf8YaEhRtyV3Cx1_hEPHk3zBqMw-YKggB5jS-vYVcc06v5lbcuaox9L05t6vulBWzvDrndep6015jKXXJNV_fI9WEbW79PZpk-thjUqCpaG1pNj7EkBCwUHHSK1MUX4iedVrTFYl1QPMSl5_aIgyo9xxj0GQgYGDzL97RHkX1lhcdxFPPk6zmdnltSJGpBbR-Qw7180h-4LR-DqxDFzC25MMYoLkufSxYJHZgy5KnwS1XqUKWeZLH0BAZevRImUhNFUqUIEMiEF8Obh2Snqiv9mNCAqzTQTOpIIuRgLKVhKvSFl8D-Sqm0Q9j6DxeqBStHzoyzYh00H2bFn2rpkDebTrMGq-Pf4q_WqitgTGGgRFS6Xi0KlnCYxnjCQeZRo8rNB6EjFv9CS7ql5I0A4nVvt1TTE4vb7XsNfXqHuFv2UDQlr8XfrPbJf8q_JDcGk-FBcfBx9OkpuYmtNtcoeUZ2lvOVfg5u1FK-aMfAL40gEtk |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3ra9swEBclhTIYY-9lTw2GP83Dlp8a-EOInXXdkhbSbu0nI8lWF9baIY-V_ve7k-1sWcdg_mJjnYXxSeeT7u73I-QNDxEmLfDsQitYoMSFsrkQygZLyArpqlBok-U7CfdP_IPT4HSHdBFTLD5bzt_hyZhpvEA6HFwXHicHU2s4HSZn1iT7Ok0m1tHgQ2a2qTFJwjpKR8m1lSb1D72y0sOkw2ccpw1IYXN4nhfBEn83jsGR75Hdwy9Zlv6KO0TM35C8gqvd4RT9vZvtf9kNB_VmnuXtqxpj4MvvJgX-tx_Z6C6503qgdNAMmXtkp6zuk71xG2N_QOZpeW6wqFFltNa0mp1jaQiMVHDUKVIYX4lrOqtoi8m6pLiZSy_NVgdV5QJj0RcgoGESrd7TAUUWljVuy1HMl68XdHZpyJGoAbd9SE5G2fFw3255GWyFaGZ2wYXWWnFZuFyyQJSeLnweC7dQRemr2JEslI7AAKxTgEHVQSBVjECBTDgh3HlEelVdlU8I9biKvZLJMpAIPRhKqZnyXeFEsM5SKu4T1n3hXLWg5cidcZF3wfNxmv-plj55u3lo3mB2_Fv8dae6HOYWBkxEVdbrZc4iDuaMRxxkHjeq3HQID2IRMLTEW0reCCBu93ZLNftm8Ltdp6FR7xN7azzkTemrecEg4sxGanswslFT--8-_U_5V2QP5kT--ePk0zNyCxtNylH0nPRWi3X5AryplXzZToGfvyUUaA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Degeneration+of+nigrostriatal+pathway+in+patients+with+middle+cerebral+infarct%3A+A+diffusion+tensor+imaging+study&rft.jtitle=Medicine+%28Baltimore%29&rft.au=Seo%2C+Jeong+Pyo&rft.au=Koo%2C+Dong+Kyun&rft.date=2023-04-07&rft.issn=1536-5964&rft.eissn=1536-5964&rft.volume=102&rft.issue=14&rft.spage=e33370&rft_id=info:doi/10.1097%2FMD.0000000000033370&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0025-7974&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0025-7974&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0025-7974&client=summon |