Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome

• Published in: Journal of thrombosis and haemostasis Vol. 9; no. 10; pp. 1985 - 1992
• Main Authors: TERUEL, R., PÉREZ‐SÁNCHEZ, C., CORRAL, J., HERRANZ, M. T., PÉREZ‐ANDREU, V., SAIZ, E., GARCÍA‐BARBERÁ, N., MARTÍNEZ‐MARTÍNEZ, I., ROLDÁN, V., VICENTE, V., LÓPEZ‐PEDRERA, C., MARTÍNEZ, C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2011
• Subjects: Adult; Aged; antiphospholipid syndrome; Antiphospholipid Syndrome - metabolism; Autoimmune diseases; Blotting, Western; Case-Control Studies; Cell Line; Female; Humans; Lupus Erythematosus, Systemic - metabolism; Male; MicroRNAs - genetics; MicroRNAs - physiology; Middle Aged; miRNAs; Real-Time Polymerase Chain Reaction; systemic lupus erythematosus; Thromboplastin - metabolism; thrombosis; tissue factor

Background: Tissue factor (TF) is the main initiator of the coagulation cascade and elements that may upregulate its expression might provoke thrombotic events. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are autoimmune diseases characterized by a high TF expression in mon...