Apoptotic phenomena are not a major cause of enteric neuronal loss in constipated patients with dementia

• Published in: Neuropathology Vol. 27; no. 1; pp. 67 - 72
• Main Authors: Bassotti, Gabrio, Villanacci, Vincenzo, Fisogni, Simona, Cadei, Morris, Di Fabio, Francesco, Salerni, Bruno
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.02.2007
• Subjects: Aged, 80 and over; apoptosis; Apoptosis - physiology; Colectomy; Colon - innervation; Colon - pathology; Colon - physiopathology; constipation; Constipation - complications; Constipation - surgery; dementia; Dementia - complications; Enteric Nervous System - pathology; Enteric Nervous System - physiopathology; Female; Humans; Immunohistochemistry; Male; Middle Aged; neuronal loss; Neurons - pathology

Chronic constipation is a frequent symptom in patients with dementia, especially in those institutionalized. However, few data are available on the neuropathological aspects of the colon in such patients. We investigated the enteric neuropathology of the colon in two patients with longstanding demen...