Light Activates the Translational Regulatory Kinase GCN2 via Reactive Oxygen Species Emanating from the Chloroplast

• Published in: The Plant cell Vol. 32; no. 4; pp. 1161 - 1178
• Main Authors: Lokdarshi, Ansul, Guan, Ju, Urquidi Camacho, Ricardo A., Cho, Sung Ki, Morgan, Philip W., Leonard, Madison, Shimono, Masaki, Day, Brad, von Arnim, Albrecht G.
• Format: Journal Article
• Language: English
• Published: England American Society of Plant Biologists 01.04.2020
• Subjects: Arabidopsis - enzymology; Arabidopsis - radiation effects; Arabidopsis Proteins - metabolism; Chitin - metabolism; Chloroplasts - metabolism; Chloroplasts - radiation effects; Eukaryotic Initiation Factor-2 - metabolism; Gene Ontology; Herbicides - toxicity; Hydrogen Peroxide - pharmacology; Light; Mutation - genetics; Phosphorylation - radiation effects; Photosynthesis - drug effects; Protein Biosynthesis - radiation effects; Protein Kinases - metabolism; Reactive Oxygen Species - metabolism; Ribosomes - drug effects; Ribosomes - metabolism; Ribosomes - radiation effects; Seedlings - drug effects; Seedlings - growth & development; Seedlings - radiation effects; Transcriptome - genetics

Cytosolic mRNA translation is subject to global and mRNA-specific controls. Phosphorylation of the translation initiation factor eIF2α anchors a reversible regulatory switch that represses cytosolic translation globally. The stress-responsive GCN2 kinase is the only known kinase for eIF2α serine 56...