Determinants of temporal change in telomere length and its associations with chronic complications and mortality in type 2 diabetes: the Fremantle diabetes study phase II

• Published in: Cardiovascular diabetology Vol. 24; no. 1; pp. 267 - 13
• Main Authors: Yang, Chieh-Hsin, Huang, Michael L H, Davis, Wendy A, Jenkins, Alicia J, Davis, Timothy M E
• Format: Journal Article
• Language: English
• Published: England BioMed Central 03.07.2025; BMC
• Subjects: Adult; Age Factors; Aged; Aging; Australia - epidemiology; Bilirubin; Biomarkers; Cardiovascular disease; Cerebrovascular disease; Chronic Disease; Creatinine; Diabetes; Diabetes complications; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - mortality; Female; Genetic testing; Glucose; Heart attacks; Humans; Ischemia; Longitudinal studies; Male; Middle Aged; Mortality; Prognosis; Prospective Studies; Regression analysis; Research ethics; Risk Assessment; Risk Factors; Statistical analysis; Telomerase; Telomere - genetics; Telomere Homeostasis; Telomere length; Telomere Shortening; Telomeres; Time Factors; Type 2 diabetes; Yeast; Australia; Germany; Type 2 diabetes; Cardiovascular disease; Telomere length; Diabetes complications; Mortality

Relative telomere length (rTL), a biomarker of biological ageing, has been implicated in type 2 diabetes and its complications. We aimed to identify the associates of rTL change over 4 years (∆rTL), and to investigate whether rTL and ∆rTL are associated with complications and mortality in adults wit...