Recognition of DNA by Three Ferric Uptake Regulator (Fur) Homologs in Bacillus subtilis

Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commer...

Full description

Saved in:
Bibliographic Details
Published inJournal of Bacteriology Vol. 185; no. 21; pp. 6348 - 6357
Main Authors Fuangthong, Mayuree, Helmann, John D.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.11.2003
Subjects
Bacillus subtilis - genetics
Bacillus subtilis - metabolism
Bacterial Proteins - analysis
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Binding Sites
Deoxyribonucleic acid
DNA
DNA Footprinting
DNA Mutational Analysis
DNA, Bacterial - genetics
DNA, Bacterial - metabolism
DNA-Binding Proteins - analysis
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Escherichia coli Proteins
Gene Regulation
Genetics
Pathogens
Promoter Regions, Genetic
Repressor Proteins - metabolism
Trans-Activators - metabolism
Transcription Factors - metabolism
Online AccessGet full text

Cover

Abstract Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0021-9193 Online ISSN: 1098-5530 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JB .asm.org, visit: JB       
AbstractList Bacillus subtilis contains three Fur homologs: Fur, PerR, and Zur. Despite significant sequence similarities, they respond to different stimuli and regulate different sets of genes. DNA target site comparisons indicate that all three paralogs recognize operators with a core 7-1-7 inverted repeat. The corresponding consensus sequences are identical at five or more of the seven defined positions. Using site-directed mutagenesis, the Per box at the mrgA promoter was altered to mimic the core 7-1-7 motif of the Fur and Zur boxes. In vitro, the mrgA promoter containing a Zur box was only recognized by Zur, as demonstrated by DNase I footprinting assays. In contrast, both Fur and PerR bound to the mrgA promoter region containing a consensus Fur box. Expression analysis of these promoters is consistent with the in vitro data demonstrating as few as 1 or 2 base changes per half-site are sufficient to alter regulation. Similarly, the Fur box at the feuA promoter can be converted into a Per or a Zur box by appropriate mutations. While both Fur and PerR could recognize some of the same synthetic operator sequences, no naturally occurring sites are known that are subject to dual regulation. However, the PerR-regulated zosA gene is controlled from a regulatory region that contains both Per and Fur boxes. Although purified Fur protein bound to the candidate Fur boxes, Fur has little effect on zosA expression-possibly due to the location of the Fur boxes relative to the zosA promoter. Together, our results identify two nucleotide positions that are important for the ability of PerR, Fur, and Zur to distinguish among the many closely related operator sites present in the B. subtilis genome.Bacillus subtilis contains three Fur homologs: Fur, PerR, and Zur. Despite significant sequence similarities, they respond to different stimuli and regulate different sets of genes. DNA target site comparisons indicate that all three paralogs recognize operators with a core 7-1-7 inverted repeat. The corresponding consensus sequences are identical at five or more of the seven defined positions. Using site-directed mutagenesis, the Per box at the mrgA promoter was altered to mimic the core 7-1-7 motif of the Fur and Zur boxes. In vitro, the mrgA promoter containing a Zur box was only recognized by Zur, as demonstrated by DNase I footprinting assays. In contrast, both Fur and PerR bound to the mrgA promoter region containing a consensus Fur box. Expression analysis of these promoters is consistent with the in vitro data demonstrating as few as 1 or 2 base changes per half-site are sufficient to alter regulation. Similarly, the Fur box at the feuA promoter can be converted into a Per or a Zur box by appropriate mutations. While both Fur and PerR could recognize some of the same synthetic operator sequences, no naturally occurring sites are known that are subject to dual regulation. However, the PerR-regulated zosA gene is controlled from a regulatory region that contains both Per and Fur boxes. Although purified Fur protein bound to the candidate Fur boxes, Fur has little effect on zosA expression-possibly due to the location of the Fur boxes relative to the zosA promoter. Together, our results identify two nucleotide positions that are important for the ability of PerR, Fur, and Zur to distinguish among the many closely related operator sites present in the B. subtilis genome.
Bacillus subtilis contains three Fur homologs: Fur, PerR, and Zur. Despite significant sequence similarities, they respond to different stimuli and regulate different sets of genes. DNA target site comparisons indicate that all three paralogs recognize operators with a core 7-1-7 inverted repeat. The corresponding consensus sequences are identical at five or more of the seven defined positions. Using site-directed mutagenesis, the Per box at the mrgA promoter was altered to mimic the core 7-1-7 motif of the Fur and Zur boxes. In vitro, the mrgA promoter containing a Zur box was only recognized by Zur, as demonstrated by DNase I footprinting assays. In contrast, both Fur and PerR bound to the mrgA promoter region containing a consensus Fur box. Expression analysis of these promoters is consistent with the in vitro data demonstrating as few as 1 or 2 base changes per half-site are sufficient to alter regulation. Similarly, the Fur box at the feuA promoter can be converted into a Per or a Zur box by appropriate mutations. While both Fur and PerR could recognize some of the same synthetic operator sequences, no naturally occurring sites are known that are subject to dual regulation. However, the PerR-regulated zosA gene is controlled from a regulatory region that contains both Per and Fur boxes. Although purified Fur protein bound to the candidate Fur boxes, Fur has little effect on zosA expression—possibly due to the location of the Fur boxes relative to the zosA promoter. Together, our results identify two nucleotide positions that are important for the ability of PerR, Fur, and Zur to distinguish among the many closely related operator sites present in the B. subtilis genome.
Bacillus subtilis contains three Fur homologs: Fur, PerR, and Zur. Despite significant sequence similarities, they respond to different stimuli and regulate different sets of genes. DNA target site comparisons indicate that all three paralogs recognize operators with a core 7-1-7 inverted repeat. The corresponding consensus sequences are identical at five or more of the seven defined positions. Using site-directed mutagenesis, the Per box at the mrgA promoter was altered to mimic the core 7-1-7 motif of the Fur and Zur boxes. In vitro, the mrgA promoter containing a Zur box was only recognized by Zur, as demonstrated by DNase I footprinting assays. In contrast, both Fur and PerR bound to the mrgA promoter region containing a consensus Fur box. Expression analysis of these promoters is consistent with the in vitro data demonstrating as few as 1 or 2 base changes per half-site are sufficient to alter regulation. Similarly, the Fur box at the feuA promoter can be converted into a Per or a Zur box by appropriate mutations. While both Fur and PerR could recognize some of the same synthetic operator sequences, no naturally occurring sites are known that are subject to dual regulation. However, the PerR-regulated zosA gene is controlled from a regulatory region that contains both Per and Fur boxes. Although purified Fur protein bound to the candidate Fur boxes, Fur has little effect on zosA expression-possibly due to the location of the Fur boxes relative to the zosA promoter. Together, our results identify two nucleotide positions that are important for the ability of PerR, Fur, and Zur to distinguish among the many closely related operator sites present in the B. subtilis genome. [PERIODICAL ABSTRACT]
Bacillus subtilis contains three Fur homologs: Fur, PerR, and Zur. Despite significant sequence similarities, they respond to different stimuli and regulate different sets of genes. DNA target site comparisons indicate that all three paralogs recognize operators with a core 7-1-7 inverted repeat. The corresponding consensus sequences are identical at five or more of the seven defined positions. Using site-directed mutagenesis, the Per box at the mrgA promoter was altered to mimic the core 7-1-7 motif of the Fur and Zur boxes. In vitro, the mrgA promoter containing a Zur box was only recognized by Zur, as demonstrated by DNase I footprinting assays. In contrast, both Fur and PerR bound to the mrgA promoter region containing a consensus Fur box. Expression analysis of these promoters is consistent with the in vitro data demonstrating as few as 1 or 2 base changes per half-site are sufficient to alter regulation. Similarly, the Fur box at the feuA promoter can be converted into a Per or a Zur box by appropriate mutations. While both Fur and PerR could recognize some of the same synthetic operator sequences, no naturally occurring sites are known that are subject to dual regulation. However, the PerR-regulated zosA gene is controlled from a regulatory region that contains both Per and Fur boxes. Although purified Fur protein bound to the candidate Fur boxes, Fur has little effect on zosA expression-possibly due to the location of the Fur boxes relative to the zosA promoter. Together, our results identify two nucleotide positions that are important for the ability of PerR, Fur, and Zur to distinguish among the many closely related operator sites present in the B. subtilis genome.
Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0021-9193 Online ISSN: 1098-5530 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JB .asm.org, visit: JB       
Author Mayuree Fuangthong
John D. Helmann
AuthorAffiliation Department of Microbiology, Cornell University, Ithaca, New York 14853-8101
AuthorAffiliation_xml – name: Department of Microbiology, Cornell University, Ithaca, New York 14853-8101
Author_xml – sequence: 1
  givenname: Mayuree
  surname: Fuangthong
  fullname: Fuangthong, Mayuree
  organization: Department of Microbiology, Cornell University, Ithaca, New York 14853-8101
– sequence: 2
  givenname: John D.
  surname: Helmann
  fullname: Helmann, John D.
  organization: Department of Microbiology, Cornell University, Ithaca, New York 14853-8101
BackLink https://www.ncbi.nlm.nih.gov/pubmed/14563870$$D View this record in MEDLINE/PubMed
BookMark eNqFUs1u1DAYtFAR3RZeAVkcEBwS_Bs7Byp1C0upKpCqVhwt23GyXrLxYiegvj2OulSllx4sHzzffDOeOQIHQxgcABCjEmMiP1wsSyx5SXBZUSaLinJREoToM7DAqBKFlJQcgAVCBBc1rukhOEppgxBmjJMX4BAzXlEp0AL8uHI2dIMffRhgaOGnb6fQ3MLrdXQOrlyM3sKb3ah_OnjluqnXY4jw3WqK7-F52IY-dAn6AS619X0_JZgmM_rep5fgeav75F7t72Nws_p8fXZeXH7_8vXs9LKwjKOxaEXDW0ZEoxlykjcVr4yhDBPb0IbXzFWOVKZmFUO4MbRtDRVSOG5r3mhDOD0GH-94d5PZusa6YYy6V7votzreqqC9-v9l8GvVhd-K4JphlOff7udj-DW5NKqtT9b1vR5cmJISmNQonyeBWEohkJgVvXkE3IQpDvkTFCEix4MYzaDXD2Xf6_0XTAac3AFsDClF1yrrRz2nlF34XmGk5iaoi2XezLMbNTdBzU1QcxMygXxEcL_j6dG9g7Xv1n98dEqnrdqYh3D6FzX5wlk
CODEN JOBAAY
CitedBy_id crossref_primary_10_1007_s10534_008_9192_1
crossref_primary_10_1039_c3mt20224k
crossref_primary_10_1093_nar_gku1304
crossref_primary_10_1099_mic_0_053579_0
crossref_primary_10_1111_j_1365_2958_2006_05577_x
crossref_primary_10_1128_JB_187_19_6659_6667_2005
crossref_primary_10_1002_jobm_202400001
crossref_primary_10_1128_mBio_02079_18
crossref_primary_10_1111_j_1462_2920_2007_01537_x
crossref_primary_10_1007_s00438_006_0115_y
crossref_primary_10_1007_s12275_021_1457_1
crossref_primary_10_1128_AEM_71_12_8314_8322_2005
crossref_primary_10_1016_j_bbrc_2014_06_015
crossref_primary_10_1093_nar_gkp198
crossref_primary_10_1186_s12866_015_0345_4
crossref_primary_10_1099_mic_0_057000_0
crossref_primary_10_1371_journal_pone_0179666
crossref_primary_10_1093_nar_gku123
crossref_primary_10_1007_s00203_007_0310_1
crossref_primary_10_1111_j_1365_2958_2008_06192_x
crossref_primary_10_1128_JB_00495_08
crossref_primary_10_1159_000079570
crossref_primary_10_1128_JB_06005_11
crossref_primary_10_1002_1873_3468_13120
crossref_primary_10_1111_1462_2920_12628
crossref_primary_10_1186_1471_2180_9_128
crossref_primary_10_1093_nar_gkt1258
crossref_primary_10_1016_j_cbpa_2022_102135
crossref_primary_10_1128_JB_00262_12
crossref_primary_10_1016_j_febslet_2005_08_067
crossref_primary_10_1007_s00792_015_0759_9
crossref_primary_10_1128_aem_01903_22
crossref_primary_10_1128_JB_00199_12
crossref_primary_10_1371_journal_pbio_1001987
crossref_primary_10_1186_1472_6807_12_1
crossref_primary_10_1089_ars_2017_7359
crossref_primary_10_1371_journal_pone_0176188
crossref_primary_10_1099_mic_0_28325_0
crossref_primary_10_3389_fmicb_2022_987756
crossref_primary_10_1111_j_1574_6976_2010_00233_x
crossref_primary_10_1128_IAI_00435_10
crossref_primary_10_1128_jb_00022_23
crossref_primary_10_1186_s12864_015_1661_7
crossref_primary_10_1007_s12275_017_7051_x
crossref_primary_10_1128_JB_00086_17
crossref_primary_10_1128_JB_05493_11
crossref_primary_10_1007_s10534_018_0120_8
crossref_primary_10_1111_j_1365_2443_2006_00949_x
crossref_primary_10_1074_jbc_M113_456590
crossref_primary_10_1111_mmi_13368
crossref_primary_10_1099_mic_0_28342_0
crossref_primary_10_1128_aem_01451_23
crossref_primary_10_3389_fgene_2021_821535
crossref_primary_10_1007_s13213_015_1134_x
crossref_primary_10_1146_annurev_micro_60_080805_142149
crossref_primary_10_1016_j_abb_2014_01_029
crossref_primary_10_1016_j_mib_2005_02_007
crossref_primary_10_1007_s10534_006_9070_7
crossref_primary_10_1039_c5mt00043b
crossref_primary_10_1007_s12275_010_9199_5
crossref_primary_10_1099_mic_0_075655_0
crossref_primary_10_1111_j_1365_2958_2012_08066_x
crossref_primary_10_1128_JB_06566_11
crossref_primary_10_1016_j_jmb_2005_10_079
crossref_primary_10_1074_jbc_M603968200
crossref_primary_10_1186_s12866_015_0342_7
crossref_primary_10_1002_bit_22820
crossref_primary_10_3389_fmicb_2016_00275
crossref_primary_10_1111_j_1574_6968_2004_tb09658_x
crossref_primary_10_1016_j_abb_2021_108770
crossref_primary_10_1111_mmi_13158
crossref_primary_10_1128_JB_00120_06
crossref_primary_10_1128_JB_01851_06
crossref_primary_10_1128_JB_01166_13
crossref_primary_10_1007_s00203_021_02342_2
crossref_primary_10_1128_JB_00351_09
crossref_primary_10_1016_j_gene_2007_12_007
crossref_primary_10_1016_j_jplph_2011_08_006
crossref_primary_10_1128_JB_00098_15
crossref_primary_10_3390_microorganisms7100455
crossref_primary_10_1038_s41598_018_25157_6
crossref_primary_10_1074_jbc_REV120_007746
crossref_primary_10_1099_mic_0_27552_0
crossref_primary_10_1021_jz301689b
crossref_primary_10_1128_AEM_04027_15
crossref_primary_10_1128_JB_01978_07
crossref_primary_10_3389_fmicb_2018_01580
crossref_primary_10_1021_cb500783g
crossref_primary_10_1093_pcp_pch034
crossref_primary_10_1128_JB_00487_16
crossref_primary_10_1128_JB_00304_12
crossref_primary_10_1007_s11274_022_03456_5
crossref_primary_10_1111_j_1574_6976_2006_00030_x
crossref_primary_10_1371_journal_pgen_1006515
crossref_primary_10_1128_JB_06486_11
Cites_doi 10.1016/S0014-5793(02)03363-X
10.1046/j.1365-2958.1996.353884.x
10.1046/j.1365-2958.1998.00921.x
10.1006/abio.1997.2457
10.1128/jb.169.6.2624-2630.1987
10.1111/j.1574-6968.1994.tb07294.x
10.1128/JB.184.23.6508-6514.2002
10.1073/pnas.95.17.9761
10.1093/nar/17.10.3865
10.1128/JB.181.14.4299-4307.1999
10.1128/JB.183.6.1921-1927.2001
10.1128/JB.184.22.6123-6129.2002
10.1006/jmbi.1998.2119
10.1046/j.1365-2958.2001.02543.x
10.1016/S0022-2836(02)00849-5
10.1046/j.1365-2958.1997.3151679.x
10.1099/00221287-143-8-2763
10.1046/j.1365-2958.2003.03648.x
10.1128/JB.185.7.2194-2202.2003
10.1006/abbi.1999.1518
10.1128/JB.180.22.5815-5821.1998
10.1128/jb.179.6.1909-1917.1997
10.1046/j.1365-2958.2003.03445.x
10.1128/jb.178.22.6579-6586.1996
10.1128/JB.185.6.1967-1975.2003
10.1016/S0065-2911(01)44010-0
10.1128/jb.175.17.5428-5437.1993
10.1128/JB.185.1.243-253.2003
10.1073/pnas.92.18.8190
10.1128/JB.182.13.3802-3808.2000
10.1128/JB.184.12.3276-3286.2002
10.1046/j.1365-2958.2002.03113.x
10.1046/j.1365-2958.2001.02703.x
10.1128/jb.169.5.2223-2230.1987
10.1128/JB.184.21.5826-5832.2002
10.1111/j.1365-2958.1995.mmi_18020295.x
10.1046/j.1365-2958.1997.2811637.x
10.1016/S1369-5274(00)00184-3
10.1128/9781555817992.ch29
10.1046/j.1365-2958.2003.03337.x
10.1128/jb.175.15.4605-4614.1993
10.1046/j.1365-2958.2002.03068.x
10.1128/JB.183.24.7318-7328.2001
10.1093/nar/22.22.4673
10.1093/nar/18.20.6097
10.1046/j.1365-2958.2000.01732.x
ContentType Journal Article
Copyright Copyright American Society for Microbiology Nov 2003
Copyright © 2003, American Society for Microbiology 2003
Copyright_xml – notice: Copyright American Society for Microbiology Nov 2003
– notice: Copyright © 2003, American Society for Microbiology 2003
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7TM
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
7X8
5PM
DOI 10.1128/JB.185.21.6348-6357.2003
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Bacteriology Abstracts (Microbiology B)
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Genetics Abstracts
Virology and AIDS Abstracts
Technology Research Database
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Nucleic Acids Abstracts
AIDS and Cancer Research Abstracts
Engineering Research Database
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
CrossRef
Genetics Abstracts
MEDLINE


Bacteriology Abstracts (Microbiology B)
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1067-8832
1098-5530
EndPage 6357
ExternalDocumentID PMC219410
752553751
14563870
10_1128_JB_185_21_6348_6357_2003
jb_185_21_6348
Genre Research Support, U.S. Gov't, Non-P.H.S
Research Support, U.S. Gov't, P.H.S
Comparative Study
Journal Article
Feature
GrantInformation_xml – fundername: NIGMS NIH HHS
  grantid: GM59323
– fundername: NIGMS NIH HHS
  grantid: R01 GM059323
GroupedDBID ---
-DZ
-~X
.55
.GJ
0R~
186
18M
1VV
29J
2WC
39C
3O-
4.4
53G
5GY
5RE
5VS
79B
85S
8WZ
9M8
A6W
AAGFI
AAYXX
ABPPZ
ACGFO
ACGOD
ACNCT
ACPRK
ADBBV
ADXHL
AENEX
AFFDN
AFFNX
AFRAH
AGCDD
AGVNZ
AI.
AIDAL
AJUXI
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BKOMP
BTFSW
C1A
CITATION
CJ0
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
FRP
GX1
H13
HYE
HZ~
IH2
KQ8
L7B
MVM
NHB
O9-
OHT
OK1
P-O
P-S
P2P
PQQKQ
QZG
RHI
RNS
RPM
RSF
RXW
TAE
TR2
UHB
UKR
UPT
VH1
W8F
WH7
WHG
WOQ
X7M
Y6R
YQT
YR2
YZZ
ZCA
ZCG
ZGI
ZXP
ZY4
~02
~KM
ABTAH
CGR
CUY
CVF
ECM
EIF
NPM
PKN
RHF
UCJ
VQA
YIN
7QL
7TM
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
7X8
5PM
ID FETCH-LOGICAL-c450t-f7d5f427da40e85d656bb3412cd3d594e6e26b946401db3ffb3787e5c95dab253
ISSN 0021-9193
IngestDate Thu Aug 21 14:10:32 EDT 2025
Fri Jul 11 01:31:45 EDT 2025
Thu Jul 10 22:17:16 EDT 2025
Mon Jun 30 08:40:25 EDT 2025
Wed Feb 19 02:33:36 EST 2025
Tue Jul 01 02:44:49 EDT 2025
Thu Apr 24 23:05:19 EDT 2025
Wed May 18 15:54:44 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 21
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c450t-f7d5f427da40e85d656bb3412cd3d594e6e26b946401db3ffb3787e5c95dab253
Notes SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-2
content type line 23
Corresponding author. Mailing address: Department of Microbiology, Wing Hall, Cornell University, Ithaca, NY 14853-8101. Phone: (607) 255-6570. Fax: (607) 255-3904. E-mail address for J. D. Helmann: jdh9@cornell.edu.
PMID 14563870
PQID 227106043
PQPubID 40724
PageCount 10
ParticipantIDs crossref_citationtrail_10_1128_JB_185_21_6348_6357_2003
proquest_miscellaneous_18877075
proquest_miscellaneous_71290129
crossref_primary_10_1128_JB_185_21_6348_6357_2003
pubmedcentral_primary_oai_pubmedcentral_nih_gov_219410
proquest_journals_227106043
highwire_asm_jb_185_21_6348
pubmed_primary_14563870
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20031101
2003-11-00
2003-Nov
PublicationDateYYYYMMDD 2003-11-01
PublicationDate_xml – month: 11
  year: 2003
  text: 20031101
  day: 01
PublicationDecade 2000
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Washington
PublicationTitle Journal of Bacteriology
PublicationTitleAlternate J Bacteriol
PublicationYear 2003
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References (e_1_3_2_4_2) 2002; 45
e_1_3_2_41_2
e_1_3_2_43_2
(e_1_3_2_44_2) 1997; 23
e_1_3_2_45_2
(e_1_3_2_24_2) 1996; 19
e_1_3_2_47_2
(e_1_3_2_2_2) 1997; 24
(e_1_3_2_46_2) 2002; 383
(e_1_3_2_42_2) 2003; 47
(e_1_3_2_13_2) 2002; 529
e_1_3_2_9_2
e_1_3_2_16_2
(e_1_3_2_49_2) 2000; 373
e_1_3_2_7_2
e_1_3_2_39_2
(e_1_3_2_40_2) 2000; 35
e_1_3_2_31_2
e_1_3_2_3_2
(e_1_3_2_38_2) 1998; 255
e_1_3_2_14_2
e_1_3_2_35_2
(e_1_3_2_18_2) 1998; 95
(e_1_3_2_26_2) 2003; 48
(e_1_3_2_34_2) 2002; 322
e_1_3_2_50_2
(e_1_3_2_28_2) 2001; 4
(e_1_3_2_12_2) 1995; 92
e_1_3_2_27_2
e_1_3_2_48_2
e_1_3_2_29_2
(e_1_3_2_17_2) 1998; 283
(e_1_3_2_5_2) 1989; 17
e_1_3_2_21_2
e_1_3_2_23_2
(e_1_3_2_37_2) 1997; 143
(e_1_3_2_22_2) 2002; 45
e_1_3_2_6_2
e_1_3_2_19_2
e_1_3_2_30_2
(e_1_3_2_15_2) 1994; 124
(e_1_3_2_25_2) 2001; 44
e_1_3_2_32_2
e_1_3_2_11_2
e_1_3_2_36_2
(e_1_3_2_10_2) 1995; 18
(e_1_3_2_20_2) 2001; 42
(e_1_3_2_8_2) 1998; 29
(e_1_3_2_33_2) 2001; 41
References_xml – volume: 529
  start-page: 151
  year: 2002
  ident: e_1_3_2_13_2
  publication-title: FEBS Lett.
  doi: 10.1016/S0014-5793(02)03363-X
– volume: 19
  start-page: 125
  year: 1996
  ident: e_1_3_2_24_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.1996.353884.x
– volume: 29
  start-page: 189
  year: 1998
  ident: e_1_3_2_8_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.1998.00921.x
– volume: 255
  start-page: 158
  year: 1998
  ident: e_1_3_2_38_2
  publication-title: Anal. Biochem.
  doi: 10.1006/abio.1997.2457
– ident: e_1_3_2_14_2
  doi: 10.1128/jb.169.6.2624-2630.1987
– volume: 124
  start-page: 255
  year: 1994
  ident: e_1_3_2_15_2
  publication-title: FEMS Microbiol Lett.
  doi: 10.1111/j.1574-6968.1994.tb07294.x
– ident: e_1_3_2_23_2
  doi: 10.1128/JB.184.23.6508-6514.2002
– volume: 95
  start-page: 9761
  year: 1998
  ident: e_1_3_2_18_2
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.95.17.9761
– volume: 17
  start-page: 3865
  year: 1989
  ident: e_1_3_2_5_2
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/17.10.3865
– ident: e_1_3_2_7_2
  doi: 10.1128/JB.181.14.4299-4307.1999
– ident: e_1_3_2_43_2
  doi: 10.1128/JB.183.6.1921-1927.2001
– ident: e_1_3_2_9_2
  doi: 10.1128/JB.184.22.6123-6129.2002
– volume: 283
  start-page: 537
  year: 1998
  ident: e_1_3_2_17_2
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.1998.2119
– volume: 41
  start-page: 849
  year: 2001
  ident: e_1_3_2_33_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2001.02543.x
– volume: 322
  start-page: 983
  year: 2002
  ident: e_1_3_2_34_2
  publication-title: J. Mol. Biol.
  doi: 10.1016/S0022-2836(02)00849-5
– volume: 24
  start-page: 7
  year: 1997
  ident: e_1_3_2_2_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.1997.3151679.x
– volume: 143
  start-page: 2763
  year: 1997
  ident: e_1_3_2_37_2
  publication-title: Microbiology
  doi: 10.1099/00221287-143-8-2763
– ident: e_1_3_2_27_2
  doi: 10.1046/j.1365-2958.2003.03648.x
– ident: e_1_3_2_35_2
  doi: 10.1128/JB.185.7.2194-2202.2003
– volume: 373
  start-page: 1
  year: 2000
  ident: e_1_3_2_49_2
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1006/abbi.1999.1518
– ident: e_1_3_2_41_2
– ident: e_1_3_2_21_2
  doi: 10.1128/JB.180.22.5815-5821.1998
– ident: e_1_3_2_39_2
  doi: 10.1128/jb.179.6.1909-1917.1997
– volume: 48
  start-page: 495
  year: 2003
  ident: e_1_3_2_26_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2003.03445.x
– ident: e_1_3_2_6_2
  doi: 10.1128/jb.178.22.6579-6586.1996
– ident: e_1_3_2_36_2
  doi: 10.1128/JB.185.6.1967-1975.2003
– volume: 44
  start-page: 1
  year: 2001
  ident: e_1_3_2_25_2
  publication-title: Adv. Microb. Physiol.
  doi: 10.1016/S0065-2911(01)44010-0
– ident: e_1_3_2_11_2
  doi: 10.1128/jb.175.17.5428-5437.1993
– ident: e_1_3_2_30_2
  doi: 10.1128/JB.185.1.243-253.2003
– volume: 92
  start-page: 8190
  year: 1995
  ident: e_1_3_2_12_2
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.92.18.8190
– ident: e_1_3_2_16_2
  doi: 10.1128/JB.182.13.3802-3808.2000
– ident: e_1_3_2_19_2
  doi: 10.1128/JB.184.12.3276-3286.2002
– volume: 45
  start-page: 1613
  year: 2002
  ident: e_1_3_2_4_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2002.03113.x
– volume: 42
  start-page: 939
  year: 2001
  ident: e_1_3_2_20_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2001.02703.x
– ident: e_1_3_2_50_2
  doi: 10.1128/jb.169.5.2223-2230.1987
– ident: e_1_3_2_29_2
– ident: e_1_3_2_3_2
  doi: 10.1128/JB.184.21.5826-5832.2002
– volume: 18
  start-page: 295
  year: 1995
  ident: e_1_3_2_10_2
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.1995.mmi_18020295.x
– volume: 23
  start-page: 835
  year: 1997
  ident: e_1_3_2_44_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.1997.2811637.x
– volume: 4
  start-page: 172
  year: 2001
  ident: e_1_3_2_28_2
  publication-title: Curr. Opin. Microbiol.
  doi: 10.1016/S1369-5274(00)00184-3
– ident: e_1_3_2_32_2
  doi: 10.1128/9781555817992.ch29
– volume: 47
  start-page: 903
  year: 2003
  ident: e_1_3_2_42_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2003.03337.x
– ident: e_1_3_2_47_2
  doi: 10.1128/jb.175.15.4605-4614.1993
– volume: 45
  start-page: 997
  year: 2002
  ident: e_1_3_2_22_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2002.03068.x
– ident: e_1_3_2_31_2
  doi: 10.1128/JB.183.24.7318-7328.2001
– ident: e_1_3_2_48_2
  doi: 10.1093/nar/22.22.4673
– volume: 383
  start-page: 945
  year: 2002
  ident: e_1_3_2_46_2
  publication-title: Biol. Chem.
– ident: e_1_3_2_45_2
  doi: 10.1093/nar/18.20.6097
– volume: 35
  start-page: 623
  year: 2000
  ident: e_1_3_2_40_2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2000.01732.x
SSID ssj0014452
Score 2.113952
Snippet Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
Bacillus subtilis contains three Fur homologs: Fur, PerR, and Zur. Despite significant sequence similarities, they respond to different stimuli and regulate...
Bacillus subtilis contains three Fur homologs: Fur, PerR, and Zur. Despite significant sequence similarities, they respond to different stimuli and regulate...
SourceID pubmedcentral
proquest
pubmed
crossref
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 6348
SubjectTerms Bacillus subtilis - genetics
Bacillus subtilis - metabolism
Bacterial Proteins - analysis
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Binding Sites
Deoxyribonucleic acid
DNA
DNA Footprinting
DNA Mutational Analysis
DNA, Bacterial - genetics
DNA, Bacterial - metabolism
DNA-Binding Proteins - analysis
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Escherichia coli Proteins
Gene Regulation
Genetics
Pathogens
Promoter Regions, Genetic
Repressor Proteins - metabolism
Trans-Activators - metabolism
Transcription Factors - metabolism
Title Recognition of DNA by Three Ferric Uptake Regulator (Fur) Homologs in Bacillus subtilis
URI http://jb.asm.org/content/185/21/6348.abstract
https://www.ncbi.nlm.nih.gov/pubmed/14563870
https://www.proquest.com/docview/227106043
https://www.proquest.com/docview/18877075
https://www.proquest.com/docview/71290129
https://pubmed.ncbi.nlm.nih.gov/PMC219410
Volume 185
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdgCIkXxPfK-PADD6AqpXHsfDyubNU0jSKhVvTNshN7K7Tp1CQP5a_nHMdpC6sYVGoUJXYS-X6-3Dl3v0PoXRQJ4QeRBt8kox7NNPOkjpSXpDpV8ILRTJgF_c-j8GxCz6ds6mqVN9klpeylP2_MK_kfqcIxkKvJkv0HybYXhQOwD_KFLUgYtreS8VcX_WONvpPRcW1NgnhUVxvKxbRbXZfihymNUpecr6tpxMNqZRYDrpYLo_nqgNiBSGfzeVV0i0qWs_ms2GO0SkvuvLMWP6xEfmkoCC5t8s-6WqkNXNR84eowmyCdk51lhqDJt9tSnSaWw7flDDeqk21hxKY6N5owDCyD5p8qmpi0g_NBDzr3iN8zDT3DileTs25eS-5T_OgLH04uLvj4dDq-i-4RcAfqpO5pG8oDPiFrWOHtI7qILRJ_3HefXTPEUUPf5Gb8Hi27ZX6MH6GHjQjwsQXBY3RH5U_QfVtJdP0UfduCAl5qDFDAco1rKGALBWyhgFso4PcAhA_YwQDPcuxggB0MnqHJ8HT86cxramZ4KWX90tNRxjQlUSZoX8UsA3NdSrBUSJoFGUuoChUJZUJD8KszGWgtA1DZiqUJy4QkLHiODvJlrg4RViqJYd4yP4pDGqZMKCIoeAuxDBPz66DIDSFPG0J5U9dkzmvHksT8fMBh8DnxuRl8bgbflD0NOshve15bUpVb9DlyUuKiWPDvcrsdnHWC480ELTghYD6HfQp937ZnQXuaT2IiV8uqgEvEUQRW8_4WkVmohX8HvbAw2Dwx-B4BvO46KNwBSNvAMLfvnslnVzWDO5gJ1O-__OtNj9CDzVx8hQ7KVaVegxFcyjf1DPgF9fOtxg
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Recognition+of+DNA+by+three+ferric+uptake+regulator+%28Fur%29+homologs+in+Bacillus+subtilis&rft.jtitle=Journal+of+bacteriology&rft.au=Fuangthong%2C+Mayuree&rft.au=Helmann%2C+John+D&rft.date=2003-11-01&rft.issn=0021-9193&rft.volume=185&rft.issue=21&rft.spage=6348&rft_id=info:doi/10.1128%2FJB.185.21.6348-6357.2003&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9193&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9193&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9193&client=summon