Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus

• Published in: Journal of virology Vol. 91; no. 19
• Main Authors: Chang, Pey-Jium, Chen, Lee-Wen, Chen, Li-Yu, Hung, Chien-Hui, Shih, Ying-Ju, Wang, Shie-Shan
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.10.2017
• Subjects: Antigens, Viral - metabolism; Butyric Acid - pharmacology; Cell Line, Tumor; Cell Proliferation; Cyclopentanes - pharmacology; Genome and Regulation of Viral Gene Expression; HEK293 Cells; Herpesvirus 8, Human - pathogenicity; Humans; Immediate-Early Proteins - genetics; Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics; Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism; Nuclear Proteins - metabolism; Promoter Regions, Genetic - drug effects; Pyrimidines - pharmacology; Sarcoma, Kaposi - pathology; Sarcoma, Kaposi - virology; Tetradecanoylphorbol Acetate - pharmacology; Trans-Activators - genetics; Ubiquitin-Activating Enzymes - antagonists & inhibitors; Virus Activation - drug effects; ORF50; lytic reactivation; LANA; Kaposi's sarcoma-associated herpesvirus; KSHV; MLN4924

The switch of Kaposi's sarcoma-associated herpesvirus (KSHV) from latency to lytic replication is a key event for viral dissemination and pathogenesis. MLN4924, a novel neddylation inhibitor, reportedly causes the onset of KSHV reactivation but impairs later phases of the viral lytic program in...