Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein as a Screening Tool for Significant Liver Fibrosis in Health Checkup

• Published in: International journal of molecular sciences Vol. 22; no. 1; p. 40
• Main Authors: Tamaki, Nobuharu, Kurosaki, Masayuki, Takahashi, Yuka, Itakura, Yoshie, Kirino, Sakura, Inada, Kento, Yamashita, Koji, Sekiguchi, Shuhei, Hayakawa, Yuka, Osawa, Leona, Higuchi, Mayu, Takaura, Kenta, Maeyashiki, Chiaki, Kaneko, Shun, Yasui, Yutaka, Tsuchiya, Kaoru, Nakanishi, Hiroyuki, Itakura, Jun, Loomba, Rohit, Izumi, Namiki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 22.12.2020
• Subjects: Aged; Aged, 80 and over; Antigens, Neoplasm - metabolism; Biomarkers - metabolism; Cross-Sectional Studies; Elasticity Imaging Techniques; Female; Humans; Liver Cirrhosis - diagnosis; Liver Cirrhosis - metabolism; Male; Membrane Glycoproteins - metabolism; Middle Aged; Plant Lectins - metabolism; Prospective Studies; Receptors, N-Acetylglucosamine - metabolism; ROC Curve; WFA+-M2BP; liver fibrosis; screening; FIB-4

Chronic liver disease is generally widespread, and a test for screening fibrotic subjects in a large population is needed. The ability of Wisteria floribunda agglutinin-positive mac-2 binding protein (WFA+-M2BP) to detect significant fibrosis was investigated in health checkup subjects in this resea...