Tumour regression grading after chemoradiotherapy for locally advanced rectal cancer: A near pathologic complete response does not translate into good clinical outcome

• Published in: Radiotherapy and oncology Vol. 112; no. 1; pp. 44 - 51
• Main Authors: Swellengrebel, Hendrik A.M, Bosch, Steven L, Cats, Annemieke, Vincent, Andrew D, Dewit, Luc G.H, Verwaal, Vic J, Nagtegaal, Iris D, Marijnen, Corrie A.M
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.07.2014
• Subjects: Adenocarcinoma - pathology; Adenocarcinoma - therapy; Adenocarcinoma, Mucinous - pathology; Adenocarcinoma, Mucinous - therapy; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic - therapeutic use; Capecitabine; Chemoradiotherapy; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Female; Fluorouracil - analogs & derivatives; Fluorouracil - therapeutic use; Hematology, Oncology and Palliative Medicine; Humans; Lymph Nodes - pathology; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Staging; Neoplasm, Residual; Outcome; Preoperative Care; Proportional Hazards Models; Radiotherapy, Conformal; Radiotherapy, Intensity-Modulated; Rectal cancer; Rectal Neoplasms - pathology; Rectal Neoplasms - therapy; Rectum - surgery; Remission Induction; Retrospective Studies; Survival Rate; Tumour regression grade; Tumour regression grade; Rectal cancer; Chemoradiotherapy; Outcome

Abstract Background After preoperative chemoradiotherapy (CRT) for rectal cancer, clinically undetectable residual tumour deposits or pathologic lymph nodes may remain in the mesorectum. Aim The aim of this study was to report histopathological effects of CRT and factors affecting outcome in a unifo...