Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus

• Published in: Journal of virology Vol. 94; no. 7
• Main Authors: Wan, Yushun, Shang, Jian, Graham, Rachel, Baric, Ralph S., Li, Fang
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 17.03.2020
• Subjects: Amino Acid Sequence; Angiotensin-Converting Enzyme 2; Animals; Betacoronavirus - classification; Betacoronavirus - physiology; China; Chiroptera - virology; Coronavirus Infections - virology; COVID-19; Host Specificity; Humans; Models, Molecular; Peptidyl-Dipeptidase A - chemistry; Phylogeny; Pneumonia, Viral - virology; Protein Domains; Receptors, Virus - chemistry; SARS-CoV-2; Sequence Alignment; Severe acute respiratory syndrome-related coronavirus - physiology; Spike Glycoprotein, Coronavirus - chemistry; Virus-Cell Interactions; China; animal reservoir; cross-species transmission; angiotensin-converting enzyme 2; 2019-nCoV; SARS coronavirus; human-to-human transmission

The recent emergence of Wuhan coronavirus (2019-nCoV) puts the world on alert. 2019-nCoV is reminiscent of the SARS-CoV outbreak in 2002 to 2003. Our decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host re...