SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

• Published in: The Journal of experimental medicine Vol. 217; no. 12
• Main Authors: Veras, Flavio Protasio, Pontelli, Marjorie Cornejo, Silva, Camila Meirelles, Toller-Kawahisa, Juliana E., de Lima, Mikhael, Nascimento, Daniele Carvalho, Schneider, Ayda Henriques, Caetité, Diego, Tavares, Lucas Alves, Paiva, Isadora M., Rosales, Roberta, Colón, David, Martins, Ronaldo, Castro, Italo Araujo, Almeida, Glaucia M., Lopes, Maria Isabel Fernandes, Benatti, Maíra Nilson, Bonjorno, Letícia Pastorelli, Giannini, Marcela Cavichioli, Luppino-Assad, Rodrigo, Almeida, Sérgio Luna, Vilar, Fernando, Santana, Rodrigo, Bollela, Valdes R., Auxiliadora-Martins, Maria, Borges, Marcos, Miranda, Carlos Henrique, Pazin-Filho, Antônio, da Silva, Luis Lamberti P., Cunha, Larissa Dias, Zamboni, Dario S., Dal-Pizzol, Felipe, Leiria, Luiz O., Siyuan, Li, Batah, Sabrina, Fabro, Alexandre, Mauad, Thais, Dolhnikoff, Marisa, Duarte-Neto, Amaro, Saldiva, Paulo, Cunha, Thiago Mattar, Alves-Filho, José Carlos, Arruda, Eurico, Louzada-Junior, Paulo, Oliveira, Renê Donizeti, Cunha, Fernando Queiroz
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 07.12.2020
• Subjects: A549 Cells; Adult; Angiotensin-Converting Enzyme 2; Betacoronavirus - physiology; Brief Definitive Report; Cell Death; Coronavirus Infections - blood; Coronavirus Infections - immunology; Coronavirus Infections - pathology; Coronavirus Infections - virology; COVID-19; Epithelial Cells - pathology; Epithelial Cells - virology; Extracellular Traps - physiology; Female; HeLa Cells; Humans; Innate Immunity and Inflammation; Male; Neutrophil Activation; Pandemics; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - blood; Pneumonia, Viral - immunology; Pneumonia, Viral - pathology; Pneumonia, Viral - virology; SARS-CoV-2; Serine Proteases - metabolism; Suction; Trachea - immunology

Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigate...