The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity

• Published in: The Journal of experimental medicine Vol. 211; no. 5; pp. 827 - 840
• Main Authors: Chevrier, Stéphane, Emslie, Dianne, Shi, Wei, Kratina, Tobias, Wellard, Cameron, Karnowski, Alexander, Erikci, Erdem, Smyth, Gordon K, Chowdhury, Kamal, Tarlinton, David, Corcoran, Lynn M
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 05.05.2014
• Subjects: Animals; B-Lymphocytes - metabolism; Bromodeoxyuridine; Cell Differentiation - physiology; Cell Survival - physiology; Chromatin Immunoprecipitation; Enzyme-Linked Immunosorbent Assay; Enzyme-Linked Immunospot Assay; Flow Cytometry; Gene Expression Regulation - genetics; Gene Expression Regulation - physiology; Immunohistochemistry; Interferon Regulatory Factors - metabolism; Mice; Microarray Analysis; Plasma Cells - physiology; Real-Time Polymerase Chain Reaction; Sequence Analysis, RNA; Statistics, Nonparametric; Transcription Factors - metabolism

The transcriptional network regulating antibody-secreting cell (ASC) differentiation has been extensively studied, but our current understanding is limited. The mechanisms of action of known "master" regulators are still unclear, while the participation of new factors is being revealed. He...