Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes

• Published in: Cells (Basel, Switzerland) Vol. 9; no. 2; p. 464
• Main Authors: Asare-Bediako, Bright, Noothi, Sunil, Li Calzi, Sergio, Athmanathan, Baskaran, Vieira, Cristiano, Adu-Agyeiwaah, Yvonne, Dupont, Mariana, Jones, Bryce, Wang, Xiaoxin, Chakraborty, Dibyendu, Levi, Moshe, Nagareddy, Prabhakara, Grant, Maria
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 18.02.2020; MDPI AG
• Subjects: Animals; Body Weight; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Retinopathy - physiopathology; Diet, Fat-Restricted; Diet, High-Fat; Diet, Western; Disease Models, Animal; Electroretinography; Insulin Resistance; Mice; Mice, Inbred C57BL; neural infarcts; Obesity - physiopathology; Phenotype; Prediabetic State - physiopathology; Retina - physiopathology; retinal phenotype; vascular leakage; vascular leakage; retinal phenotype; neural infarcts

We sought to delineate the retinal features associated with the high-fat diet (HFD) mouse, a widely used model of obesity. C57BL/6 mice were fed either a high-fat (60% fat; HFD) or low-fat (10% fat; LFD) diet for up to 12 months. The effect of HFD on body weight and insulin resistance were measured....