Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target
Phagocytosis is an actin-based process used by macrophages to clear particles greater than 0.5 microm in diameter. In addition to its role in immunological responses, phagocytosis is also necessary for tissue remodeling and repair. To prevent catastrophic autoimmune reactions, phagocytosis must be t...
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| Published in | Journal of cell science Vol. 115; no. Pt 4; pp. 849 - 856 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Legacy CDMS
15.02.2002
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Phagocytosis is an actin-based process used by macrophages to clear particles greater than 0.5 microm in diameter. In addition to its role in immunological responses, phagocytosis is also necessary for tissue remodeling and repair. To prevent catastrophic autoimmune reactions, phagocytosis must be tightly regulated. It is commonly assumed that the recognition/selection of phagocytic targets is based solely upon receptor-ligand binding. Here we report an important new criterion, that mechanical parameters of the target can dramatically affect the efficiency of phagocytosis. When presented with particles of identical chemical properties but different rigidity, macrophages showed a strong preference to engulf rigid objects. Furthermore, phagocytosis of soft particles can be stimulated with the microinjection of constitutively active Rac1 but not RhoA, and with lysophosphatidic acid, an agent known to activate the small GTP-binding proteins of the Rho family. These data suggest a Rac1-dependent mechanosensory mechanism for phagocytosis, which probably plays an important role in a number of physiological and pathological processes from embryonic development to autoimmune diseases. |
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| AbstractList | Phagocytosis is an actin-based process used by macrophages to clear particles greater than 0.5 μm in diameter. In addition to its role in immunological responses, phagocytosis is also necessary for tissue remodeling and repair. To prevent catastrophic autoimmune reactions, phagocytosis must be tightly regulated. It is commonly assumed that the recognition/selection of phagocytic targets is based solely upon receptor-ligand binding. Here we report an important new criterion, that mechanical parameters of the target can dramatically affect the efficiency of phagocytosis. When presented with particles of identical chemical properties but different rigidity, macrophages showed a strong preference to engulf rigid objects. Furthermore, phagocytosis of soft particles can be stimulated with the microinjection of constitutively active Rac1 but not RhoA, and with lysophosphatidic acid, an agent known to activate the small GTP-binding proteins of the Rho family. These data suggest a Rac1-dependent mechanosensory mechanism for phagocytosis, which probably plays an important role in a number of physiological and pathological processes from embryonic development to autoimmune diseases. Phagocytosis is an actin-based process used by macrophages to clear particles greater than 0.5 microm in diameter. In addition to its role in immunological responses, phagocytosis is also necessary for tissue remodeling and repair. To prevent catastrophic autoimmune reactions, phagocytosis must be tightly regulated. It is commonly assumed that the recognition/selection of phagocytic targets is based solely upon receptor-ligand binding. Here we report an important new criterion, that mechanical parameters of the target can dramatically affect the efficiency of phagocytosis. When presented with particles of identical chemical properties but different rigidity, macrophages showed a strong preference to engulf rigid objects. Furthermore, phagocytosis of soft particles can be stimulated with the microinjection of constitutively active Rac1 but not RhoA, and with lysophosphatidic acid, an agent known to activate the small GTP-binding proteins of the Rho family. These data suggest a Rac1-dependent mechanosensory mechanism for phagocytosis, which probably plays an important role in a number of physiological and pathological processes from embryonic development to autoimmune diseases. |
| Audience | PUBLIC |
| Author | Wang, Yu-li Beningo, Karen A. |
| Author_xml | – sequence: 1 givenname: Karen A. surname: Beningo fullname: Beningo, Karen A. organization: University of Massachusetts Medical School, Department of Physiology – sequence: 2 givenname: Yu-li surname: Wang fullname: Wang, Yu-li |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11865040$$D View this record in MEDLINE/PubMed |
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| Snippet | Phagocytosis is an actin-based process used by macrophages to clear particles greater than 0.5 microm in diameter. In addition to its role in immunological... Phagocytosis is an actin-based process used by macrophages to clear particles greater than 0.5 μm in diameter. In addition to its role in immunological... |
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| SubjectTerms | Acrylic Resins - chemistry Acrylic Resins - metabolism Actin Cytoskeleton - drug effects Actin Cytoskeleton - ultrastructure Animals Cells, Cultured Life Sciences (General) Lysophospholipids - metabolism Macrophages - drug effects Macrophages - physiology Macrophages - ultrastructure Mice Mice, Inbred C3H Opsonin Proteins - metabolism Particle Size Phagocytosis rac1 GTP-Binding Protein - metabolism Receptors, Fc - metabolism Stress, Mechanical |
| Title | Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target |
| URI | https://ntrs.nasa.gov/citations/20040088440 https://www.ncbi.nlm.nih.gov/pubmed/11865040 https://search.proquest.com/docview/71475313 |
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