The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: Has it been overlooked?

• Published in: Biochimica et biophysica acta Vol. 1840; no. 4; pp. 1313 - 1330
• Main Authors: Stark, Romana, Kibbey, Richard G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2014
• Subjects: adenosine triphosphate; Anaplerosis; Animals; blood glucose; Gluconeogenesis; Gluconeogenesis - physiology; glucose; Glucose - metabolism; glycogen; guanosine triphosphate; homeostasis; Homeostasis - physiology; Humans; insulin; Insulin secretion; Insulin-Secreting Cells - physiology; islets of Langerhans; Isoenzymes - physiology; liver; mitochondria; Mitochondria - enzymology; Mitochondria - metabolism; Mitochondrial GTP; Mitochondrial Proteins - physiology; PEPCK-M; Phosphoenolpyruvate Carboxykinase (GTP) - physiology; Succinyl coenzyme A synthetase; tissues; tricarboxylic acid cycle; αKG; mtPEP; GTP; SCS; ITP; mtGlyc-3-PDH; Mitochondrial GTP; ANT; αKGT; mtGTP; GDH; Insulin secretion; MDH; Glu; LDH; SCS-ATP; IDP; PEPCK-M; NDPK; PDH; mtAAT; SCS-GTP; CIC; cytGlyc-3-PDH; cytMDH; Glyc-3-PDH; Asp; DIC; Gluconeogenesis; PEPCK; Asp/Glu; Anaplerosis; OAA; PEPCK-C; Succinyl coenzyme A synthetase; PC; AAT; GSIS; cytAAT; Mal; PEP; PK; GAPDH; mtMDH

Plasma glucose levels are tightly regulated within a narrow physiologic range. Insulin-mediated glucose uptake by tissues must be balanced by the appearance of glucose from nutritional sources, glycogen stores, or gluconeogenesis. In this regard, a common pathway regulating both glucose clearance an...