Marine Prostanoids with Cytotoxic Activity from Octocoral Clavularia spp

• Published in: Marine drugs Vol. 22; no. 5; p. 219
• Main Authors: Cheng, Ming-Ya, Hsu, I-Chi, Huang, Shi-Ying, Chuang, Ya-Ting, Ke, Tzi-Yi, Chang, Hsueh-Wei, Chu, Tian-Huei, Chen, Ching-Yeu, Cheng, Yuan-Bin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.05.2024
• Subjects: Animals; Anthozoa - chemistry; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Aquatic Organisms; Ca9-22; Carbon; Cell Line, Tumor; Cell lines; Chemotherapy; Clavularia; Clavularia spp; computer simulation; corals; Cytotoxicity; genus; Humans; Inhibitory Concentration 50; Marine invertebrates; Metabolites; Molecular Structure; mouth neoplasms; Natural products; neoplasm cells; Nitric oxide; Nitric Oxide - metabolism; NMR; Nuclear magnetic resonance; Oral cancer; Prostaglandins; Prostaglandins - pharmacology; prostanoid; Secondary metabolites; Tumor cell lines; Two dimensional analysis; Taiwan; Clavularia spp; prostanoid; Ca9-22; cytotoxicity
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md22050219

Octocoral of the genus Clavularia is a kind of marine invertebrate possessing abundant cytotoxic secondary metabolites, such as prostanoids and dolabellanes. In our continuous natural product study of C. spp., two previously undescribed prostanoids [clavulone I-15-one (1) and 12-O-deacetylclavulone...