Titin M-line insertion sequence 7 is required for proper cardiac function in mice

• Published in: Journal of cell science Vol. 134; no. 18
• Main Authors: Biquand, Ariane, Spinozzi, Simone, Tonino, Paola, Cosette, Jérémie, Strom, Joshua, Elbeck, Zaher, Knöll, Ralph, Granzier, Henk, Lostal, William, Richard, Isabelle
• Format: Journal Article
• Language: English
• Published: England Company of Biologists 15.09.2021; The Company of Biologists Ltd
• Subjects: Alternative Splicing - genetics; Animals; Biochemistry, Molecular Biology; Biotechnology; Cardiomyopathy, Dilated - genetics; Cardiomyopathy, Dilated - metabolism; Cell Biology and Disease; Connectin - genetics; Connectin - metabolism; DNA Transposable Elements; Genetics; Human genetics; Life Sciences; Mice; Molecular biology; Protein Kinases - genetics; Protein Kinases - metabolism; Sarcomeres - metabolism; Heart failure; Alternative splicing; Mex5; is7; Cardiomyopathy; Titin

Titin is a giant sarcomeric protein that is involved in a large number of functions, with a primary role in skeletal and cardiac sarcomere organization and stiffness. The titin gene (TTN) is subject to various alternative splicing events, but in the region that is present at the M-line, the only exo...