Functional MRI of the cortical sensorimotor system in patients with hereditary spastic paraplegia

• Published in: Spinal cord Vol. 50; no. 12; pp. 885 - 890
• Main Authors: Tomberg, T, Braschinsky, M, Rannikmäe, K, Kepler, J, Kepler, K, Kõrv, J, Linnamägi, Ü, Asser, T
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2012; Nature Publishing Group
• Subjects: 631/1647/245/1627; 631/378/2629; 692/699/375/374; Adult; Aged; Anatomy; Ankle; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Brodmann's area; Cerebellum; Cerebellum - pathology; Cerebral Cortex - pathology; Cerebrospinal fluid. Meninges. Spinal cord; Computer programs; Cortex; Databases, Factual; Female; Finger; Functional Laterality - physiology; Functional magnetic resonance imaging; Hand; Hand - innervation; Hand - physiology; Heat shock proteins; Hereditary spastic parplegia; Hospitals; Human Physiology; Humans; Image Processing, Computer-Assisted; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Mathematical models; Medical sciences; Middle Aged; Motor Cortex - pathology; Movement - physiology; Nervous system; Nervous system (semeiology, syndromes); Neurochemistry; Neurology; Neuropsychology; Neurosciences; original-article; Paresis; Radiodiagnosis. Nmr imagery. Nmr spectrometry; sensorimotor system; software; Somatosensory Cortex - pathology; Spastic Paraplegia, Hereditary - genetics; Spastic Paraplegia, Hereditary - pathology; spasticity; Spinal cord; Statistical analysis; supplementary motor area; Young Adult; Strümpell–Lorrain disease; hereditary spastic paraplegia; functional magnetic resonance imaging; cortical reorganisation; Human; Nervous system diseases; Vertebral canal; Nuclear magnetic resonance imaging; Genetic disease; Cerebral disorder; Hereditary spastic paraplegia; Central nervous system disease; Degenerative disease; Strümpell―Lorrain disease; Spinal cord disease; Functional imaging

Objectives: The study aimed to use functional magnetic resonance imaging to ascertain changes in sensorimotor system function in patients with hereditary spastic paraplegia and to correlate it with severity of spasticity and paresis. Setting: Tartu University Hospital, Tartu, Estonia. Methods: Nine...