Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 48; pp. 7762 - 7767
• Main Author: Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Onate-Ocana Margarita Camorlinga-Ponce Leopoldo Munoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados
• Format: Journal Article
• Language: English
• Published: United States Department of Pathology, Instituto Nacional de Cancerología INCan, Mexico City, Mexico%Department of Immunology and Rheumatology,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico%Department of Gastroenterology (INCan),Mexico City, Mexico%Medical Research Unit on Infectious and Parasitic Diseases, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN-SXXI),Instituto Mexicano del Seguro Social (IMSS), Mexico City,Mexico%Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez,Mexico City, Mexico 28.12.2006; Baishideng Publishing Group Co., Limited
• Subjects: Adenocarcinoma - ethnology; Adenocarcinoma - genetics; Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Gastric Cancer; Gastritis - genetics; Gene Frequency; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Genotype; HLA-DQ Antigens - genetics; Humans; Male; Mexico - ethnology; Middle Aged; Stomach Neoplasms - ethnology; Stomach Neoplasms - genetics; 基因表达; 墨西哥; 慢性胃炎; Mexico; Hpylori; HLA-DQ5; Chronic gastritis; HLA-DQ; HLA-DQB10501; Diffuse-type adenocarcinoma; Gastric cancer
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i48.7762

AIM： To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS： Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay （EUSA） method. RESULTS： We found a significant increased frequency of HLA-DQBI＊0401 allele in Hpylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 × 10^-7, odds ratio （OR） = 4.96; 95% confidence interval （95% CI）, 3.87-6.35]. We also found a significant increased frequency of HLA-DQBI＊0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals （P = 1 × 10^4, OR = 13.07; 95% CI, 2.82-85.14）. CONCLUSION： HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and difffuse-type gastric adenocarcinoma in the Mexican Mestizo population.