Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients

AIM： To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS： Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99...

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Published inWorld journal of gastroenterology : WJG Vol. 12; no. 48; pp. 7762 - 7767
Main Author Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Onate-Ocana Margarita Camorlinga-Ponce Leopoldo Munoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados
Format Journal Article
LanguageEnglish
Published United States Department of Pathology, Instituto Nacional de Cancerología INCan, Mexico City, Mexico%Department of Immunology and Rheumatology,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico%Department of Gastroenterology (INCan),Mexico City, Mexico%Medical Research Unit on Infectious and Parasitic Diseases, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN-SXXI),Instituto Mexicano del Seguro Social (IMSS), Mexico City,Mexico%Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez,Mexico City, Mexico 28.12.2006
Baishideng Publishing Group Co., Limited
Subjects
Adenocarcinoma - ethnology
Adenocarcinoma - genetics
Adult
Aged
Aged, 80 and over
Chronic Disease
Female
Gastric Cancer
Gastritis - genetics
Gene Frequency
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Genotype
HLA-DQ Antigens - genetics
Humans
Male
Mexico - ethnology
Middle Aged
Stomach Neoplasms - ethnology
Stomach Neoplasms - genetics
基因表达
墨西哥
慢性胃炎
Mexico
Hpylori
HLA-DQ5
Chronic gastritis
HLA-DQ
HLA-DQB10501
Diffuse-type adenocarcinoma
Gastric cancer
Online AccessGet full text
ISSN1007-9327
2219-2840
DOI10.3748/wjg.v12.i48.7762

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Abstract AIM： To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS： Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay （EUSA） method. RESULTS： We found a significant increased frequency of HLA-DQBI＊0401 allele in Hpylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 × 10^-7, odds ratio （OR） = 4.96; 95% confidence interval （95% CI）, 3.87-6.35]. We also found a significant increased frequency of HLA-DQBI＊0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals （P = 1 × 10^4, OR = 13.07; 95% CI, 2.82-85.14）. CONCLUSION： HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and difffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
AbstractList R73; AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method.RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 × 10-7, odds ratio (OR) = 4.96; 95%confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07;95% CI, 2.82-85.14).CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
AIM： To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS： Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay （EUSA） method. RESULTS： We found a significant increased frequency of HLA-DQBI＊0401 allele in Hpylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 × 10^-7, odds ratio （OR） = 4.96; 95% confidence interval （95% CI）, 3.87-6.35]. We also found a significant increased frequency of HLA-DQBI＊0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals （P = 1 × 10^4, OR = 13.07; 95% CI, 2.82-85.14）. CONCLUSION： HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and difffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori -positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 × 10 -7 , odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals ( P = 1 × 10 -6 , OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori -related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.AIMTo determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method.METHODSOligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method.We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 x 10(-7), odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 x 10(-6), OR = 13.07; 95% CI, 2.82-85.14).RESULTSWe found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 x 10(-7), odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 x 10(-6), OR = 13.07; 95% CI, 2.82-85.14).HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.CONCLUSIONHLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method. We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 x 10(-7), odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 x 10(-6), OR = 13.07; 95% CI, 2.82-85.14). HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
Author Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Onate-Ocana Margarita Camorlinga-Ponce Leopoldo Munoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados
AuthorAffiliation Department of Pathology, Instituto Nacional de Cancerologia （INCan）, Mexico City, Mexico Julio Granados, Department of Immunology and Rheumatology,Instituto National de Ciencias M6dicas y Nutricioen SalvadorZubirán, Mexico City, Mexico Department of Gastroenterology （INCan）,Mexico City, Mexico Medical Research Unit on Infectious and Parasitic Diseases, Hospital dePediatria, Centro M6dico National Siglo XXI （CMN-SXXI）,Instituto Mexicano del Seguro Social （IMSS）, Mexico City,Mexico Department of Physiology, Instituto Nacional de Cardiologia Ignacio Chávez,Mexico City, Mexico Department of Gastroenterology,of Physiology, Instituto Nacional de Cardiologia Ignacio Chávez,Mexico City, Mexico
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Issue 48
Keywords Hpylori
HLA-DQ5
Chronic gastritis
HLA-DQ
HLA-DQB10501
Diffuse-type adenocarcinoma
Gastric cancer
Language English
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Notes Hpy/or/
HLA-DQ5
Chronic gastritis
14-1219/R
HLA-DQ
R735.2
HLA-DQBI＊0501
Diffuse-type adenocarcinoma
Gastric cancer
HLA-DQ; HLA-DQ5; HLA-DQBI＊0501; Hpy/or/;Chronic gastritis; Gastric cancer; Diffuse-type adenocarcinoma
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Correspondence to: Roberto Herrera-Goepfert, MD, Department of Pathology, Instituto Nacional de Cancerología, Av. San Fernando #22, Col. Sección XVI, Tlalpan, 14080 México, D.F., México. rhgoepfert@yahoo.com.mx
Telephone: +52-55-56280466 Fax: +52-55-55734662
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PublicationTitle World journal of gastroenterology : WJG
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PublicationYear 2006
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Snippet AIM： To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS： Oligotyping for HLA-DQ locus was performed...
To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. Oligotyping for HLA-DQ locus was performed in 45 Mexican...
To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.AIMTo determine the HLA-DQ locus in Mexican patients with...
R73; AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.METHODS: Oligotyping for HLA-DQ locus was...
AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed...
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SubjectTerms Adenocarcinoma - ethnology
Adenocarcinoma - genetics
Adult
Aged
Aged, 80 and over
Chronic Disease
Female
Gastric Cancer
Gastritis - genetics
Gene Frequency
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Genotype
HLA-DQ Antigens - genetics
Humans
Male
Mexico - ethnology
Middle Aged
Stomach Neoplasms - ethnology
Stomach Neoplasms - genetics
基因表达
墨西哥
慢性胃炎
Title Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients
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