Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer

• Published in: Surgery Vol. 138; no. 1; pp. 71 - 77
• Main Authors: Mori, Tomohiko, Doi, Ryuichiro, Toyoda, Eiji, Koizumi, Masayuki, Ito, Daisuke, Kami, Kazuhiro, Kida, Atsushi, Masui, Toshihiko, Kawaguchi, Yoshiya, Fujimoto, Koji
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Mosby, Inc 01.07.2005; Elsevier
• Subjects: Apoptosis - drug effects; Apoptosis Regulatory Proteins; Biological and medical sciences; Caspases - metabolism; Cell Line, Tumor; Cycloheximide - pharmacology; Drug Resistance, Neoplasm; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression - drug effects; General aspects; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Membrane Glycoproteins - pharmacology; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - pathology; Protein Synthesis Inhibitors - pharmacology; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor - genetics; Signal Transduction - drug effects; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha - pharmacology; Tumors; Malignant tumor; Medicine; Resistance; Regulation(control); Treatment; Cell death; Surgery; Pancreas cancer; Digestive diseases; TNF related apoptosis inducing ligand; Strategy; Regulation; Pancreatic disease; Apoptosis

Tumor necrosis factor–related, apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in a wide variety of tumor cells, but it does not cause toxicity in the majority of normal cells. Therefore, TRAIL could become a suitable agent for anticancer therapies. However, a number of tumor cell...