S100A8 and S100A12 Proteins as Biomarkers of High Disease Activity in Patients with Rheumatoid Arthritis That Can Be Regulated by Epigenetic Drugs

• Published in: International journal of molecular sciences Vol. 24; no. 1; p. 710
• Main Authors: Roszkowski, Leszek, Jaszczyk, Bożena, Plebańczyk, Magdalena, Ciechomska, Marzena
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 31.12.2022; MDPI AG
• Subjects: biomarkers; DNA methylation; epigenetics; monocytes; rheumatoid arthritis; S100 proteins; monocytes; S100 proteins; biomarkers; DNA methylation; transcriptomics; rheumatoid arthritis; epigenetics

Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease that is still not well understood in terms of its pathogenesis and presents diagnostic and therapeutic challenges. Monocytes are key players in initiating and maintaining inflammation through the production of pro-inflammatory c...