Absorption of poorly water soluble drugs subject to apical efflux using phospholipids as solubilizers in the Caco-2 cell model - Kapitza, Susanne B.; Michel, Bettina R.; van Hoogevest, Peter; Leigh, Mathew L.S.; Imanidis, Georgios (European journal of pharmaceutics and biopharmaceutics, 2007)
Keywords: Absorption; Biological and medical sciences; Biological Transport; Caco-2; Caco-2 Cells; Cell Membrane Permeability; Cell Survival - drug effects; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug absorption; Efflux; General pharmacology; HIV Protease Inhibitors - chemistry; HIV Protease Inhibitors - pharmacokinetics; HIV-protease inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Indinavir - chemistry; Indinavir - pharmacokinetics; Kinetic modeling; Liposomes; Liposomes - chemistry; Medical sciences; Models, Theoretical; Pharmaceutical Preparations - chemistry; Pharmaceutical Preparations - metabolism; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Phospholipids; Phospholipids - chemistry; Regression Analysis; Saquinavir - chemistry; Saquinavir - pharmacokinetics; Solubility; Time Factors; Efflux; Kinetic modeling; Caco-2; Drug absorption; Phospholipids; HIV-protease inhibitors; Liposomes; Drug; Antiretroviral agent; Pharmaceutical technology; Gut; Liposome; Phospholipid; Modeling; Water solubility; Antiviral; Water absorption; Kinetics; Protease inhibitor