The many faces of the anti-COVID immune response

• Published in: The Journal of experimental medicine Vol. 217; no. 6
• Main Authors: Vardhana, Santosha A., Wolchok, Jedd D.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 01.06.2020
• Subjects: Adaptive Immunity - drug effects; Adaptive Immunity - immunology; Betacoronavirus - drug effects; Betacoronavirus - immunology; Betacoronavirus - pathogenicity; Coronavirus Infections - immunology; Coronavirus Infections - pathology; Coronavirus Infections - therapy; COVID-19; Cytokine Release Syndrome - immunology; Cytokine Release Syndrome - pathology; Cytokine Release Syndrome - therapy; Humans; Hypoxia - pathology; Hypoxia - therapy; Immunity, Innate - drug effects; Immunity, Innate - immunology; Infectious Disease and Host Defense; Inflammation - immunology; Inflammation - pathology; Inflammation - therapy; Innate Immunity and Inflammation; Interleukin-6 - antagonists & inhibitors; Interleukin-6 - immunology; Lymphopenia - immunology; Lymphopenia - pathology; Lymphopenia - therapy; Macrophages - immunology; Macrophages - pathology; Middle East Respiratory Syndrome Coronavirus - immunology; Middle East Respiratory Syndrome Coronavirus - pathogenicity; Pandemics; Pneumonia, Viral - immunology; Pneumonia, Viral - pathology; Pneumonia, Viral - therapy; Respiration, Artificial; Respiratory Distress Syndrome - pathology; Respiratory Distress Syndrome - therapy; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus - immunology; Severe acute respiratory syndrome-related coronavirus - pathogenicity

The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are curre...