The many faces of the anti-COVID immune response
The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are curre...
Saved in:
| Published in | The Journal of experimental medicine Vol. 217; no. 6 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Rockefeller University Press
01.06.2020
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity. |
|---|---|
| AbstractList | The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity. This Perspective explores the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offers suggestions to both understand and therapeutically modulate anti-COVID immunity. The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity. The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity. |
| Author | Vardhana, Santosha A. Wolchok, Jedd D. |
| AuthorAffiliation | 3 Parker Institute for Cancer Immunotherapy, San Francisco, CA 4 Human Oncology Pathogenesis Program, Department of Medicine and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 2 Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 5 Weill Cornell Medicine and Graduate School of Biomedical Sciences, New York, NY 1 Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY |
| AuthorAffiliation_xml | – name: 1 Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY – name: 5 Weill Cornell Medicine and Graduate School of Biomedical Sciences, New York, NY – name: 2 Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY – name: 3 Parker Institute for Cancer Immunotherapy, San Francisco, CA – name: 4 Human Oncology Pathogenesis Program, Department of Medicine and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY |
| Author_xml | – sequence: 1 givenname: Santosha A. orcidid: 0000-0002-3100-1298 surname: Vardhana fullname: Vardhana, Santosha A. – sequence: 2 givenname: Jedd D. orcidid: 0000-0001-6718-2222 surname: Wolchok fullname: Wolchok, Jedd D. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32353870$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkc1PwzAMxSM0xMbgxhn1yIEOJ2mb9oKExtekSbsMrlGauhDUJqPpkPjvybQNAeJky_75PcnvmAyss0jIGYUJhTy5esN2woABZCI_ICOaJhAXKc8HZATAWEwBxJAce_8GQJMkzY7IkDMeCAEjAstXjFplP6NaafSRq6M-TJTtTTxdPM9uI9O2a4tRh37lrMcTclirxuPpro7J0_3dcvoYzxcPs-nNPNZJCn2smaY6p5RjJUQOVZozlpWCilRzpGnoK1rWNa8EA1qGtirzSmOWFVVZa13wMbne6q7WZYthZftONXLVmVZ1n9IpI39vrHmVL-5DClpQTiEIXOwEOve-Rt_L1niNTaMsurWXjBciExnwDXr-0-vbZP-mALAtoDvnfYe11KZXvXEba9NICnKThQxZyH0W4ejyz9Fe91_8CwB1igw |
| CitedBy_id | crossref_primary_10_1016_j_annonc_2020_06_007 crossref_primary_10_1111_1756_185X_13909 crossref_primary_10_1007_s10096_020_04078_1 crossref_primary_10_1186_s12931_021_01613_2 crossref_primary_10_1152_physrev_00046_2020 crossref_primary_10_1186_s40560_021_00531_1 crossref_primary_10_1002_1873_3468_14180 crossref_primary_10_3390_ijms231810346 crossref_primary_10_1038_s41598_020_79035_1 crossref_primary_10_1093_ehjcvp_pvaa098 crossref_primary_10_1016_j_jaip_2020_11_016 crossref_primary_10_1016_j_matt_2021_09_022 crossref_primary_10_1016_j_prp_2022_153848 crossref_primary_10_1089_ars_2020_8247 crossref_primary_10_1172_jci_insight_151571 crossref_primary_10_3389_fped_2022_868269 crossref_primary_10_3389_fmed_2021_800492 crossref_primary_10_3389_fped_2021_629040 crossref_primary_10_1016_j_cyto_2023_156350 crossref_primary_10_2147_RMHP_S305413 crossref_primary_10_1016_j_cell_2020_08_025 crossref_primary_10_1089_vim_2021_0044 crossref_primary_10_1002_ctm2_90 crossref_primary_10_1016_S2352_3018_21_00070_9 crossref_primary_10_1021_acsami_1c00706 crossref_primary_10_2147_IDR_S445180 crossref_primary_10_1002_jmv_28751 crossref_primary_10_1055_a_2186_8108 crossref_primary_10_3390_molecules26226900 crossref_primary_10_1172_jci_insight_142032 crossref_primary_10_3389_fcimb_2023_1280600 crossref_primary_10_3390_genes14091721 crossref_primary_10_1128_JVI_00130_21 crossref_primary_10_21876_rcshci_v11i4_1184 crossref_primary_10_1038_s41467_021_24360_w crossref_primary_10_1002_cpt_1920 crossref_primary_10_1128_mbio_02906_21 crossref_primary_10_1172_jci_insight_140329 crossref_primary_10_24171_j_phrp_2022_0155 crossref_primary_10_1038_s41598_020_76781_0 crossref_primary_10_17343_sdutfd_863761 crossref_primary_10_1097_SHK_0000000000002043 crossref_primary_10_1371_journal_pone_0246681 crossref_primary_10_1016_j_jtauto_2021_100086 crossref_primary_10_3389_fimmu_2020_02008 crossref_primary_10_22207_JPAM_14_4_03 crossref_primary_10_3389_fendo_2020_00530 crossref_primary_10_1016_j_cytox_2020_100035 crossref_primary_10_1007_s00059_020_05013_y crossref_primary_10_1093_ofid_ofaa387 crossref_primary_10_1007_s00210_023_02417_5 crossref_primary_10_1016_j_bjid_2020_09_002 crossref_primary_10_1158_2159_8290_CD_20_0596 crossref_primary_10_3390_life11111152 crossref_primary_10_1016_j_mehy_2020_110161 crossref_primary_10_1111_ddg_14194_g crossref_primary_10_3389_fmed_2020_562142 crossref_primary_10_3390_ijms22157850 crossref_primary_10_1093_jn_nxab059 crossref_primary_10_4049_jimmunol_2100446 crossref_primary_10_1016_j_trsl_2021_12_001 crossref_primary_10_1007_s10456_021_09805_6 crossref_primary_10_1096_fj_202002662R crossref_primary_10_1080_2162402X_2020_1854424 crossref_primary_10_1007_s12603_021_1713_4 crossref_primary_10_1016_j_critrevonc_2020_103059 crossref_primary_10_1084_jem_20202617 crossref_primary_10_1016_j_immuni_2020_05_004 crossref_primary_10_29039_rusjbpc_2022_0510 crossref_primary_10_1177_1753466620937170 crossref_primary_10_1016_j_cmpb_2024_108073 crossref_primary_10_1093_infdis_jiaa446 crossref_primary_10_1111_sji_13083 crossref_primary_10_1136_jitc_2020_001145 crossref_primary_10_1038_s41684_021_00831_x crossref_primary_10_20411_pai_v5i1_391 crossref_primary_10_1016_j_jhazmat_2022_129173 crossref_primary_10_1186_s13287_021_02376_9 crossref_primary_10_3390_healthcare9070788 crossref_primary_10_3390_info16010034 crossref_primary_10_3390_molecules26030711 crossref_primary_10_3389_fimmu_2023_1140630 crossref_primary_10_3389_fimmu_2021_712274 crossref_primary_10_29328_journal_abb_1001017 crossref_primary_10_3889_oamjms_2024_10105 crossref_primary_10_1097_IPC_0000000000001119 crossref_primary_10_1080_17512433_2021_1903317 crossref_primary_10_1007_s12029_020_00529_2 crossref_primary_10_1111_bcp_14540 crossref_primary_10_1097_TXD_0000000000001031 crossref_primary_10_3390_cancers12123822 crossref_primary_10_1007_s00281_020_00818_9 crossref_primary_10_1038_s43856_024_00610_y crossref_primary_10_37871_jbres1380 crossref_primary_10_1016_j_omtm_2020_11_002 crossref_primary_10_2147_IMCRJ_S260252 crossref_primary_10_3389_fimmu_2021_793197 crossref_primary_10_3390_children9020249 crossref_primary_10_1080_14397595_2020_1868673 crossref_primary_10_1007_s00705_021_05012_2 crossref_primary_10_3389_fphys_2020_571416 crossref_primary_10_3390_cells10051109 crossref_primary_10_3389_fimmu_2021_778913 crossref_primary_10_1128_CMR_00094_21 crossref_primary_10_1016_j_meomic_2024_100034 crossref_primary_10_1080_17476348_2021_1960824 crossref_primary_10_3390_v13122521 crossref_primary_10_1093_cid_ciaa904 crossref_primary_10_1038_s41598_024_53087_z crossref_primary_10_1002_onco_13828 crossref_primary_10_1001_jamanetworkopen_2020_16485 crossref_primary_10_1016_j_jfma_2021_06_009 crossref_primary_10_1016_j_heliyon_2022_e11908 crossref_primary_10_1016_j_ebiom_2021_103317 crossref_primary_10_1016_j_cell_2020_10_039 crossref_primary_10_1016_j_jbior_2020_100741 crossref_primary_10_3389_fimmu_2020_01642 crossref_primary_10_3389_fimmu_2022_890517 crossref_primary_10_1152_ajpregu_00154_2022 crossref_primary_10_1177_11206721211064033 crossref_primary_10_1097_MRM_0000000000000306 crossref_primary_10_1016_j_intimp_2020_107364 crossref_primary_10_1038_s43018_020_00122_3 crossref_primary_10_1513_AnnalsATS_202006_600FR crossref_primary_10_3390_microorganisms12112272 crossref_primary_10_4103_injr_injr_264_21 crossref_primary_10_1111_all_14462 crossref_primary_10_1136_jitc_2020_001593 crossref_primary_10_3390_life13091925 crossref_primary_10_1016_j_jbior_2020_100737 crossref_primary_10_1177_09636897211010632 crossref_primary_10_3390_ijms22168660 crossref_primary_10_1016_j_ijmedinf_2023_105039 crossref_primary_10_3389_fcimb_2020_00364 crossref_primary_10_3389_fimmu_2020_570993 crossref_primary_10_3390_ph16091196 crossref_primary_10_1002_jmv_27352 crossref_primary_10_1136_jitc_2021_002838 crossref_primary_10_1007_s00011_021_01446_1 crossref_primary_10_1016_j_ejphar_2020_173551 crossref_primary_10_1016_j_crphar_2021_100058 crossref_primary_10_4110_in_2021_21_e12 crossref_primary_10_1080_20477724_2023_2174295 crossref_primary_10_3390_antiox10091440 crossref_primary_10_1002_JLB_4COVR1020_698R crossref_primary_10_1155_2020_1939768 crossref_primary_10_1186_s12967_022_03751_7 crossref_primary_10_1007_s10875_020_00927_y crossref_primary_10_1016_j_jinf_2020_06_006 crossref_primary_10_1177_17534666231183811 crossref_primary_10_1016_j_tips_2020_07_004 crossref_primary_10_1038_s41598_023_29588_8 crossref_primary_10_3389_fphar_2021_731847 crossref_primary_10_1097_MD_0000000000034866 crossref_primary_10_3389_fimmu_2022_862522 crossref_primary_10_3390_ph13090236 crossref_primary_10_3389_fimmu_2021_686462 crossref_primary_10_1016_j_jinf_2021_03_008 crossref_primary_10_1016_j_transproceed_2020_08_042 crossref_primary_10_3389_fcvm_2023_1062491 crossref_primary_10_1177_1721727X231197922 crossref_primary_10_1111_ddg_14194 crossref_primary_10_3389_fimmu_2022_843342 crossref_primary_10_3389_fmed_2021_711397 crossref_primary_10_3389_fcimb_2022_926352 crossref_primary_10_1016_j_intimp_2021_107763 crossref_primary_10_1016_j_fmre_2021_02_001 crossref_primary_10_1016_j_jphotobiol_2020_112083 crossref_primary_10_1016_j_humimm_2020_10_001 crossref_primary_10_1038_s41598_024_58426_8 crossref_primary_10_1111_papr_12951 crossref_primary_10_1038_s41467_021_25015_6 crossref_primary_10_1016_j_cytogfr_2020_05_008 crossref_primary_10_1186_s12964_022_00856_w crossref_primary_10_3389_fimmu_2022_769839 crossref_primary_10_3390_ijerph182312636 crossref_primary_10_1021_acsinfecdis_1c00070 crossref_primary_10_1097_MD_0000000000029364 crossref_primary_10_3390_cancers12113383 crossref_primary_10_1080_14789450_2021_1908894 crossref_primary_10_1515_almed_2021_0039 crossref_primary_10_1016_j_heliyon_2022_e11724 crossref_primary_10_1016_j_jaip_2020_10_043 crossref_primary_10_1152_ajplung_00146_2020 crossref_primary_10_1371_journal_pone_0254374 crossref_primary_10_3389_fimmu_2021_645989 crossref_primary_10_2217_nnm_2020_0286 crossref_primary_10_3390_ijms23158606 crossref_primary_10_17650_1726_9784_2021_22_1_71_75 crossref_primary_10_2500_aap_2021_42_200104 crossref_primary_10_1111_aji_13317 crossref_primary_10_1038_s41591_020_0979_0 crossref_primary_10_1080_07391102_2020_1790426 crossref_primary_10_3389_fimmu_2021_697622 crossref_primary_10_4102_ajlm_v12i1_2065 crossref_primary_10_1186_s13054_024_05099_4 crossref_primary_10_1186_s13062_020_00283_2 crossref_primary_10_3390_vaccines9060562 crossref_primary_10_1111_aji_13320 crossref_primary_10_1186_s13054_021_03558_w crossref_primary_10_1111_jebm_12430 crossref_primary_10_3389_fimmu_2022_832394 crossref_primary_10_4103_jispcd_JISPCD_221_21 crossref_primary_10_18527_2500_2236_2022_9_1_56_70 crossref_primary_10_3389_fimmu_2021_633769 crossref_primary_10_3389_fphar_2021_708302 crossref_primary_10_1136_jitc_2021_002835 crossref_primary_10_56294_hl2024_461 crossref_primary_10_1007_s00261_020_02693_2 crossref_primary_10_1159_000519699 crossref_primary_10_3389_fmolb_2021_635245 crossref_primary_10_1128_mSphere_00480_21 crossref_primary_10_1001_jamainternmed_2020_7976 crossref_primary_10_3389_fmed_2022_795392 crossref_primary_10_1016_j_xcrm_2020_100078 crossref_primary_10_3389_fimmu_2021_789735 crossref_primary_10_4236_psych_2022_132013 crossref_primary_10_1016_j_ejca_2021_03_033 crossref_primary_10_1016_j_jtbi_2023_111470 crossref_primary_10_21518_2079_701X_2021_9_108_113 crossref_primary_10_3390_cells9092046 crossref_primary_10_1016_j_ebiom_2021_103341 crossref_primary_10_1136_annrheumdis_2020_218323 crossref_primary_10_3390_v14030455 crossref_primary_10_1038_s41598_023_40999_5 crossref_primary_10_3390_microorganisms9122578 crossref_primary_10_1007_s00292_021_00923_y crossref_primary_10_1002_eji_202249804 crossref_primary_10_1172_JCI141777 crossref_primary_10_3389_fimmu_2020_581807 crossref_primary_10_1002_dmrr_3402 crossref_primary_10_2500_aap_2020_41_200072 crossref_primary_10_1016_j_smim_2021_101508 crossref_primary_10_1111_all_15239 crossref_primary_10_1146_annurev_bioeng_082420_124920 crossref_primary_10_1098_rsos_211606 crossref_primary_10_3389_fviro_2021_692105 crossref_primary_10_7326_M20_2889 crossref_primary_10_1002_jmv_26189 crossref_primary_10_1186_s12929_021_00784_w crossref_primary_10_3390_microorganisms9071389 crossref_primary_10_58854_jicm_1247409 crossref_primary_10_1016_j_intimp_2021_108242 crossref_primary_10_3389_fimmu_2022_1058884 crossref_primary_10_1007_s10787_022_01047_2 crossref_primary_10_3389_fimmu_2021_730088 crossref_primary_10_18527_2500_2236_2022_9_1_56_70_RU crossref_primary_10_3389_fphar_2023_1087850 crossref_primary_10_1186_s12931_023_02426_1 crossref_primary_10_1111_1744_9987_13792 crossref_primary_10_33808_clinexphealthsci_1007516 crossref_primary_10_1089_vim_2022_0036 crossref_primary_10_1371_journal_ppat_1009721 crossref_primary_10_1038_s41423_022_00902_0 crossref_primary_10_1016_j_biopha_2021_111957 crossref_primary_10_5468_ogs_22175 crossref_primary_10_1055_s_0040_1714272 crossref_primary_10_1097_MS9_0000000000000362 crossref_primary_10_1161_JAHA_120_019650 crossref_primary_10_1002_cyto_a_24484 crossref_primary_10_3389_fphar_2023_1111329 crossref_primary_10_1515_almed_2021_0006 crossref_primary_10_18093_0869_0189_2021_31_5_636_644 crossref_primary_10_1128_JVI_01683_20 crossref_primary_10_3389_fimmu_2021_686029 crossref_primary_10_3389_fphar_2020_600372 crossref_primary_10_3390_jcm10245815 crossref_primary_10_3390_biomedicines10102620 crossref_primary_10_1172_jci_insight_148435 crossref_primary_10_1016_j_vaccine_2021_10_027 crossref_primary_10_1074_jbc_AC120_015967 crossref_primary_10_1080_21645515_2020_1865774 crossref_primary_10_1080_2162402X_2020_1794424 crossref_primary_10_1016_j_imlet_2021_02_002 crossref_primary_10_7717_peerj_14227 crossref_primary_10_3390_microorganisms11010176 crossref_primary_10_3389_fimmu_2023_1232472 crossref_primary_10_1007_s00134_020_06127_x crossref_primary_10_1038_s41598_024_83026_x crossref_primary_10_1002_jbmr_4419 crossref_primary_10_1007_s11306_022_01936_1 crossref_primary_10_17352_aaa_000010 crossref_primary_10_3389_fmed_2021_675963 crossref_primary_10_1002_prp2_926 crossref_primary_10_3389_fimmu_2020_572635 crossref_primary_10_4103_ijrc_ijrc_8_21 crossref_primary_10_1186_s12879_021_06078_8 crossref_primary_10_3389_fimmu_2022_954391 crossref_primary_10_18093_0869_0189_2022_32_4_616_625 crossref_primary_10_3390_biomedicines10112770 crossref_primary_10_1007_s44231_022_00018_z crossref_primary_10_3390_vaccines11010101 crossref_primary_10_1128_msphere_00362_20 crossref_primary_10_2139_ssrn_3763768 crossref_primary_10_3389_fimmu_2022_879686 crossref_primary_10_1055_s_0043_1761916 crossref_primary_10_3389_fcell_2021_813384 crossref_primary_10_36106_ijsr_6401648 crossref_primary_10_1038_s41423_020_0516_6 crossref_primary_10_1038_s41598_023_48145_x crossref_primary_10_1080_02648725_2022_2122290 crossref_primary_10_1016_j_intcar_2020_100006 crossref_primary_10_23736_S0031_0808_21_04277_4 crossref_primary_10_1016_j_ynstr_2021_100296 crossref_primary_10_1016_j_bcp_2020_114169 crossref_primary_10_3390_life12122117 crossref_primary_10_1177_1073858420941476 crossref_primary_10_1016_j_intimp_2020_107082 crossref_primary_10_3390_v16050672 crossref_primary_10_3390_microorganisms8111718 crossref_primary_10_1007_s00296_020_04629_x crossref_primary_10_1080_21645515_2020_1830683 crossref_primary_10_3389_fphys_2021_624675 crossref_primary_10_1002_jmv_26891 crossref_primary_10_3390_v15071609 crossref_primary_10_3389_fmed_2021_651658 crossref_primary_10_1016_j_freeradbiomed_2021_06_018 crossref_primary_10_1186_s12014_024_09457_w crossref_primary_10_1186_s13643_021_01732_3 crossref_primary_10_3389_fimmu_2020_561851 crossref_primary_10_3389_fimmu_2020_579250 crossref_primary_10_2139_ssrn_3959670 crossref_primary_10_1016_j_cyto_2022_155962 crossref_primary_10_7759_cureus_29061 crossref_primary_10_1016_j_cell_2020_09_016 crossref_primary_10_1007_s11357_021_00481_4 crossref_primary_10_1111_ejh_13491 crossref_primary_10_1111_jdv_16661 crossref_primary_10_1111_sji_13039 crossref_primary_10_16899_jcm_1031086 crossref_primary_10_5005_jp_journals_10071_23905 crossref_primary_10_1139_cjpp_2021_0038 crossref_primary_10_3390_jcm9113630 crossref_primary_10_1186_s12943_021_01363_1 crossref_primary_10_3389_fphar_2023_1143158 crossref_primary_10_1099_jgv_0_001599 crossref_primary_10_1002_jmv_26656 crossref_primary_10_1080_08830185_2021_2019727 crossref_primary_10_3389_fphar_2020_00937 crossref_primary_10_1186_s12882_020_01970_y crossref_primary_10_1186_s13020_020_00415_w crossref_primary_10_3389_fmed_2022_951115 crossref_primary_10_18632_aging_202571 crossref_primary_10_3389_fimmu_2022_912336 crossref_primary_10_1515_tjb_2020_0232 crossref_primary_10_3390_biomedicines9081003 crossref_primary_10_11948_20220389 crossref_primary_10_1038_s41392_021_00764_4 crossref_primary_10_1038_s41467_024_45453_2 crossref_primary_10_1111_acer_14573 crossref_primary_10_3389_fcimb_2021_636999 crossref_primary_10_1002_eji_202049159 crossref_primary_10_3389_fimmu_2023_1136723 crossref_primary_10_1177_1559325820956800 crossref_primary_10_3390_medicina57030258 crossref_primary_10_7759_cureus_39529 crossref_primary_10_1080_17476348_2021_1866546 crossref_primary_10_1111_imm_13262 crossref_primary_10_1080_14787210_2022_2046462 crossref_primary_10_1016_j_ebiom_2021_103379 crossref_primary_10_3389_fimmu_2020_580250 crossref_primary_10_1016_j_cmi_2020_10_036 crossref_primary_10_1007_s00508_020_01763_1 crossref_primary_10_1016_j_arcmed_2021_08_005 crossref_primary_10_1017_cjn_2021_247 crossref_primary_10_1089_jir_2022_0061 crossref_primary_10_3389_fmed_2022_802312 crossref_primary_10_1172_jci_insight_189150 crossref_primary_10_3390_biomedicines9030279 crossref_primary_10_1371_journal_pone_0255335 crossref_primary_10_1016_j_chest_2022_06_007 crossref_primary_10_3390_vaccines8030404 crossref_primary_10_3389_fimmu_2021_789317 crossref_primary_10_1093_ibd_izab207 crossref_primary_10_1111_apa_15662 crossref_primary_10_2174_1389557520666201027160833 crossref_primary_10_1007_s40265_022_01803_2 crossref_primary_10_1038_s41598_020_78710_7 crossref_primary_10_4236_wjcd_2022_123018 crossref_primary_10_3389_fphar_2021_624704 crossref_primary_10_3390_antib12010005 |
| Cites_doi | 10.1007/BF00256763 10.1016/j.celrep.2011.11.005 10.1056/NEJMoa2002032 10.1056/NEJMoa0906612 10.1016/S0140-6736(03)13077-2 10.1034/j.1399-3003.1999.13a31.x 10.1038/325581b0 10.1101/2020.02.29.20029520 10.1084/jem.63.6.847 10.1007/s002280050140 10.1038/nm.4275 10.1038/s41591-018-0036-4 10.1056/NEJMoa030685 10.1016/j.immuni.2014.04.010 10.1126/science.1132505 10.1182/blood.V95.7.2240 10.1038/41131 10.1056/NEJMoa2004500 10.1016/j.cell.2018.10.038 10.1002/phar.1489 10.1038/srep25359 10.1038/nature05115 10.1016/j.jcv.2013.05.011 10.1016/S1473-3099(13)70204-4 10.1101/2020.03.04.20031120 10.1038/ni875 10.1056/NEJMra1000449 10.1016/S1097-2765(02)00599-3 10.1101/2020.03.23.20039362 10.1056/NEJMoa030634 10.1186/cc9324 10.1101/2020.03.24.004655 10.1056/NEJMoa1407222 10.1038/nrclinonc.2017.148 10.3892/etm.2017.4891 10.1073/pnas.2004168117 10.4049/jimmunol.140.5.1566 10.1097/00007890-197401000-00022 10.1016/j.cell.2008.02.043 10.1136/bmj.326.7403.1358 10.1164/ajrccm/140.6.1686 10.1056/NEJMoa1215134 10.1172/JCI62860 10.1101/2020.03.27.20045427 10.1152/ajpregu.00298.2016 10.3346/jkms.2016.31.11.1717 10.1016/j.jinf.2016.08.005 10.1056/NEJMoa0904252 10.1016/j.immuni.2007.09.006 10.1016/S0140-6736(03)13364-8 10.1016/S1665-2681(19)31749-1 10.1101/2020.03.03.20030437 10.1007/978-1-62703-523-1_7 10.1038/s41591-018-0041-7 10.1002/jmv.25819 10.1038/362758a0 10.1164/rccm.201706-1172OC 10.1016/S0140-6736(20)30183-5 10.1056/NEJMra1608077 10.1056/NEJMoa030666 10.4038/cmj.v58i2.5684 10.1007/s12072-010-9176-4 10.1126/science.1232458 10.1016/j.coi.2007.06.004 10.1001/jama.2020.2565 10.1126/science.1208421 10.7326/0003-4819-152-10-201005180-00017 10.1155/2013/989673 10.1101/2020.04.01.20048561 10.1126/sciimmunol.aan5393 10.1016/j.micinf.2012.10.008 10.1126/science.1132998 10.1016/j.cell.2011.01.011 10.1016/S0140-6736(20)30628-0 10.1126/science.1093616 10.1001/jamainternmed.2020.0994 10.1182/blood-2017-06-793141 10.1101/2020.03.24.20042655 10.1128/JVI.01505-14 10.1084/jem.160.2.521 10.1172/JCI137244 10.1056/NEJMc2001468 10.1378/chest.105.1.190 10.1186/1471-2334-11-225 10.1371/journal.pone.0008393 10.1093/intimm/5.1.97 10.1186/cc10437 10.1038/s41591-020-0817-4 10.1038/nature04444 10.4038/cmj.v57i4.5085 10.1016/j.ajpath.2013.06.023 10.1038/srep27912 10.1046/j.1365-2362.1998.00301.x 10.1182/blood-2014-05-552729 10.3389/fimmu.2020.00827 10.1126/science.abb2507 10.1016/j.micinf.2006.05.008 |
| ContentType | Journal Article |
| Copyright | 2020 Vardhana and Wolchok. 2020 Vardhana and Wolchok 2020 |
| Copyright_xml | – notice: 2020 Vardhana and Wolchok. – notice: 2020 Vardhana and Wolchok 2020 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1084/jem.20200678 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | A review of the anti-COVID immune response |
| EISSN | 1540-9538 |
| ExternalDocumentID | PMC7191310 32353870 10_1084_jem_20200678 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: P30 CA008748 – fundername: ; – fundername: ; grantid: P30 CA008748 |
| GroupedDBID | --- -~X 18M 29K 2WC 36B 4.4 53G 5GY 5RE 5VS AAYXX ABOCM ABZEH ACGFO ACNCT ACPRK ADBBV AENEX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW C45 CITATION CS3 D-I DIK DU5 E3Z EBS EMB F5P F9R GX1 H13 HYE IH2 KQ8 L7B N9A O5R O5S OK1 P2P P6G R.V RHI SJN TR2 TRP UHB W8F WOQ CGR CUY CVF ECM EIF FRP NPM RHF RPM 7X8 5PM |
| ID | FETCH-LOGICAL-c450t-c2c1c8113ed7780d58226b7175c3e1526bd1bff3d7201b1bfdb8dce669dbfcc93 |
| ISSN | 0022-1007 1540-9538 |
| IngestDate | Thu Aug 21 14:31:29 EDT 2025 Thu Jul 10 19:04:48 EDT 2025 Thu Jan 02 22:33:50 EST 2025 Tue Jul 01 00:41:14 EDT 2025 Thu Apr 24 23:13:13 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| License | 2020 Vardhana and Wolchok. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c450t-c2c1c8113ed7780d58226b7175c3e1526bd1bff3d7201b1bfdb8dce669dbfcc93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Disclosures: S.A. Vardhana reported personal fees from Immunai and personal fees from ADC Therapeutics outside the submitted work; in addition, S.A. Vardhana had a patent to PCT/US19/27610 pending. J.D. Wolchok reported personal fees from Tizona Pharmaceuticals, Adaptive Biotechnologies, Imvaq, Beigene, and Linneaus; and grants from AstraZeneca, Bristol Myers Squibb, and Sephora outside the submitted work. In addition, J.D. Wolchok had a patent to alphavirus replicon particles expressing TRP2 issued, a patent to Newcastle disease viruses for cancer therapy issued, a patent to xenogeneic DNA vaccines with royalties paid "Merial," a patent to myeloid-derived suppressor cell (MDSC) assay with royalties paid "Serametrix," a patent to anti-PD1 antibody licensed "Agenus," a patent to anti-CTLA4 antibodies licensed "Agenus," a patent to anti-GITR antibodies and methods of use thereof licensed "Agenus/Incyte," a patent to genomic signature to identify responders to ipilimumab in melanoma pending, a patent to engineered vaccinia viruses for cancer immunotherapy pending, a patent to anti-CD40 agonist mAb fused to monophosphoryl lipid A (MPL) for cancer therapy pending, a patent to CAR+ T cells targeting differentiation antigens as means to treat cancer pending, a patent to identifying and treating subjects at risk for checkpoint blockade therapy associated colitis pending, a patent to immunosuppressive follicular helper-like T cells modulated by immune checkpoint blockade pending, and a patent to phosphatidylserine targeting agents and uses thereof for adoptive T-cell therapies pending. J.D. Wolchok is a paid consultant for: Adaptive Biotech, Amgen, Apricity, Ascentage Pharma, Astellas, AstraZeneca, Bayer, Beigene, Bristol Myers Squibb, Celgene, Chugai, Eli Lilly, Elucida, F Star, Imvaq, Janssen, Kyowa Hakko Kirin, Linneaus, Merck, Neon Therapuetics, Novaritis, Polynoma, Psioxus, Recepta, Takara Bio, Trieza, Truvax, Serametrix, Surface Oncology, Syndax, and Syntalogic. |
| ORCID | 0000-0001-6718-2222 0000-0002-3100-1298 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7191310 |
| PMID | 32353870 |
| PQID | 2397676030 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7191310 proquest_miscellaneous_2397676030 pubmed_primary_32353870 crossref_citationtrail_10_1084_jem_20200678 crossref_primary_10_1084_jem_20200678 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-06-01 |
| PublicationDateYYYYMMDD | 2020-06-01 |
| PublicationDate_xml | – month: 06 year: 2020 text: 2020-06-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | The Journal of experimental medicine |
| PublicationTitleAlternate | J Exp Med |
| PublicationYear | 2020 |
| Publisher | Rockefeller University Press |
| Publisher_xml | – name: Rockefeller University Press |
| References | 2023072812440334500_bib89 Li (2023072812440334500_bib54) 2013; 15 Wrapp (2023072812440334500_bib92) 2020; 367 Rothe (2023072812440334500_bib75) 2020; 382 Huang (2023072812440334500_bib40) 2020; 395 Thompson (2023072812440334500_bib85) 2017; 377 Hay (2023072812440334500_bib37) 2017; 130 Giamarellos-Bourboulis (2023072812440334500_bib29) 2009; 4 Grupp (2023072812440334500_bib32) 2013; 368 Tate (2023072812440334500_bib84) 2016; 6 Ko (2023072812440334500_bib44) 2016; 73 Lee (2023072812440334500_bib51) 2003; 348 Eylar (2023072812440334500_bib26) 1993; 5 Duan (2023072812440334500_bib24) 2020 Akerlund (2023072812440334500_bib3) 1996; 50 2023072812440334500_bib94 2023072812440334500_bib10 2023072812440334500_bib99 2023072812440334500_bib18 Diebold (2023072812440334500_bib23) 2004; 303 Min (2023072812440334500_bib60) 2016; 6 Pellegrini (2023072812440334500_bib65) 2011; 144 2023072812440334500_bib17 Chen (2023072812440334500_bib16) 2020 Lenz (2023072812440334500_bib53) 1999; 13 Bautista (2023072812440334500_bib8) 2010; 362 2023072812440334500_bib19 Medzhitov (2023072812440334500_bib58) 1997; 388 Norelli (2023072812440334500_bib63) 2018; 24 Sun (2023072812440334500_bib82) 2013; 339 Abeysekera (2023072812440334500_bib1) 2012; 57 2023072812440334500_bib21 Rayamajhi (2023072812440334500_bib71) 2013; 1040 Perez-Padilla (2023072812440334500_bib67) 2009; 361 2023072812440334500_bib22 Lansbury (2023072812440334500_bib50) 2019; 2 Cao (2023072812440334500_bib13) 2009; 361 Shah (2023072812440334500_bib78) 1974; 17 Sotelo (2023072812440334500_bib80) 2009; 8 Moskophidis (2023072812440334500_bib61) 1993; 362 Wu (2023072812440334500_bib93) 2020 Giavridis (2023072812440334500_bib30) 2018; 24 Hon (2023072812440334500_bib38) 2003; 361 Channappanavar (2023072812440334500_bib15) 2014; 88 Reis (2023072812440334500_bib72) 1988; 140 2023072812440334500_bib31 Martinon (2023072812440334500_bib56) 2002; 10 Hagau (2023072812440334500_bib35) 2010; 14 Pichlmair (2023072812440334500_bib68) 2006; 314 Harker (2023072812440334500_bib36) 2011; 334 Rhim (2023072812440334500_bib74) 2011; 11 Lai (2023072812440334500_bib49) 2010; 152 Shin (2023072812440334500_bib79) 2007; 19 Youm (2023072812440334500_bib97) 2012; 1 Senanayake (2023072812440334500_bib77) 2013; 58 Kim (2023072812440334500_bib43) 2016; 31 Hornung (2023072812440334500_bib39) 2006; 314 Yao (2023072812440334500_bib96) 2020; 49 Sade-Feldman (2023072812440334500_bib76) 2018; 175 Jacobs (2023072812440334500_bib42) 1989; 140 Erickson (2023072812440334500_bib25) 2012; 122 Ahmed (2023072812440334500_bib2) 1984; 160 Lagunas-Rangel (2023072812440334500_bib48) 2020 Imai (2023072812440334500_bib41) 2008; 133 Chandler (2023072812440334500_bib14) 2016; 311 Poutanen (2023072812440334500_bib70) 2003; 348 Revel (2023072812440334500_bib73) 1987; 325 Mehta (2023072812440334500_bib59) 2020; 395 Stelekati (2023072812440334500_bib81) 2014; 40 Bhatraju (2023072812440334500_bib9) 2020 Tsang (2023072812440334500_bib87) 2003; 348 Zhang (2023072812440334500_bib98) 2017; 14 Suter (2023072812440334500_bib83) 1994; 105 Wherry (2023072812440334500_bib90) 2007; 27 Barber (2023072812440334500_bib7) 2006; 439 Broers (2023072812440334500_bib12) 2000; 95 Guerrero (2023072812440334500_bib34) 2014; 34 Look (2023072812440334500_bib55) 1998; 28 Wong (2023072812440334500_bib91) 2003; 326 Bradley-Stewart (2023072812440334500_bib11) 2013; 58 Peiris (2023072812440334500_bib64) 2003; 361 Pison (2023072812440334500_bib69) 1988; 14 Kotenko (2023072812440334500_bib45) 2003; 4 Arabi (2023072812440334500_bib4) 2018; 197 Maude (2023072812440334500_bib57) 2014; 371 Kuipers (2023072812440334500_bib46) 2011; 15 Lee (2023072812440334500_bib52) 2014; 124 Gao (2023072812440334500_bib28) 2013; 183 Fisicaro (2023072812440334500_bib27) 2017; 23 Day (2023072812440334500_bib20) 2006; 443 Bai (2023072812440334500_bib6) 2020; 323 Valero-Pacheco (2023072812440334500_bib88) 2013; 2013 Assiri (2023072812440334500_bib5) 2013; 13 Neelapu (2023072812440334500_bib62) 2018; 15 Xu (2023072812440334500_bib95) 2020; 26 Kumarasena (2023072812440334500_bib47) 2010; 4 Traub (2023072812440334500_bib86) 1936; 63 Zhao (2023072812440334500_bib100) 2017; 2 Peng (2023072812440334500_bib66) 2006; 8 Guan (2023072812440334500_bib33) 2020 |
| References_xml | – volume: 14 start-page: 602 year: 1988 ident: 2023072812440334500_bib69 article-title: Distribution and function of alveolar cells in multiply injured patients with trauma-induced ARDS publication-title: Intensive Care Med doi: 10.1007/BF00256763 – volume: 1 start-page: 56 year: 2012 ident: 2023072812440334500_bib97 article-title: The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence publication-title: Cell Rep doi: 10.1016/j.celrep.2011.11.005 – year: 2020 ident: 2023072812440334500_bib33 article-title: Clinical Characteristics of Coronavirus Disease 2019 in China publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa2002032 – volume: 361 start-page: 2507 year: 2009 ident: 2023072812440334500_bib13 article-title: Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa0906612 – volume: 361 start-page: 1319 year: 2003 ident: 2023072812440334500_bib64 article-title: Coronavirus as a possible cause of severe acute respiratory syndrome publication-title: Lancet doi: 10.1016/S0140-6736(03)13077-2 – volume: 13 start-page: 169 year: 1999 ident: 2023072812440334500_bib53 article-title: Oxidatively modified proteins in bronchoalveolar lavage fluid of patients with ARDS and patients at-risk for ARDS publication-title: Eur. Respir. J doi: 10.1034/j.1399-3003.1999.13a31.x – volume: 325 start-page: 581 year: 1987 ident: 2023072812440334500_bib73 article-title: Interferon-beta 2 living up to its name publication-title: Nature doi: 10.1038/325581b0 – ident: 2023072812440334500_bib18 doi: 10.1101/2020.02.29.20029520 – volume: 63 start-page: 847 year: 1936 ident: 2023072812440334500_bib86 article-title: Persistence of Lymphocytic Choriomeningitis Virus in Immune Animals and Its Relation to Immunity publication-title: J. Exp. Med doi: 10.1084/jem.63.6.847 – volume: 50 start-page: 457 year: 1996 ident: 2023072812440334500_bib3 article-title: Effect of N-acetylcysteine(NAC) treatment on HIV-1 infection: a double-blind placebo-controlled trial publication-title: Eur. J. Clin. Pharmacol doi: 10.1007/s002280050140 – volume: 23 start-page: 327 year: 2017 ident: 2023072812440334500_bib27 article-title: Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B publication-title: Nat. Med doi: 10.1038/nm.4275 – volume: 24 start-page: 739 year: 2018 ident: 2023072812440334500_bib63 article-title: Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells publication-title: Nat. Med doi: 10.1038/s41591-018-0036-4 – volume: 348 start-page: 1986 year: 2003 ident: 2023072812440334500_bib51 article-title: A major outbreak of severe acute respiratory syndrome in Hong Kong publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa030685 – volume: 40 start-page: 801 year: 2014 ident: 2023072812440334500_bib81 article-title: Bystander chronic infection negatively impacts development of CD8(+) T cell memory publication-title: Immunity doi: 10.1016/j.immuni.2014.04.010 – volume: 314 start-page: 994 year: 2006 ident: 2023072812440334500_bib39 article-title: 5′-Triphosphate RNA is the ligand for RIG-I publication-title: Science doi: 10.1126/science.1132505 – volume: 95 start-page: 2240 year: 2000 ident: 2023072812440334500_bib12 article-title: Increased transplant-related morbidity and mortality in CMV-seropositive patients despite highly effective prevention of CMV disease after allogeneic T-cell-depleted stem cell transplantation publication-title: Blood doi: 10.1182/blood.V95.7.2240 – volume: 388 start-page: 394 year: 1997 ident: 2023072812440334500_bib58 article-title: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity publication-title: Nature doi: 10.1038/41131 – year: 2020 ident: 2023072812440334500_bib9 article-title: Covid-19 in Critically Ill Patients in the Seattle Region - Case Series publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa2004500 – volume: 175 start-page: 998 year: 2018 ident: 2023072812440334500_bib76 article-title: Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma publication-title: Cell doi: 10.1016/j.cell.2018.10.038 – volume: 34 start-page: e333 year: 2014 ident: 2023072812440334500_bib34 article-title: N-Acetylcysteine treatment of rotavirus-associated diarrhea in children publication-title: Pharmacotherapy doi: 10.1002/phar.1489 – volume: 6 start-page: 25359 year: 2016 ident: 2023072812440334500_bib60 article-title: Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity publication-title: Sci. Rep doi: 10.1038/srep25359 – volume: 443 start-page: 350 year: 2006 ident: 2023072812440334500_bib20 article-title: PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression publication-title: Nature doi: 10.1038/nature05115 – volume: 58 start-page: 100 year: 2013 ident: 2023072812440334500_bib11 article-title: Cytokine responses in patients with mild or severe influenza A(H1N1)pdm09 publication-title: J. Clin. Virol doi: 10.1016/j.jcv.2013.05.011 – volume: 13 start-page: 752 year: 2013 ident: 2023072812440334500_bib5 article-title: Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study publication-title: Lancet Infect. Dis doi: 10.1016/S1473-3099(13)70204-4 – ident: 2023072812440334500_bib22 doi: 10.1101/2020.03.04.20031120 – volume: 4 start-page: 69 year: 2003 ident: 2023072812440334500_bib45 article-title: IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex publication-title: Nat. Immunol doi: 10.1038/ni875 – volume: 362 start-page: 1708 year: 2010 ident: 2023072812440334500_bib8 article-title: Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection publication-title: N. Engl. J. Med doi: 10.1056/NEJMra1000449 – volume: 10 start-page: 417 year: 2002 ident: 2023072812440334500_bib56 article-title: The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta publication-title: Mol. Cell doi: 10.1016/S1097-2765(02)00599-3 – ident: 2023072812440334500_bib89 doi: 10.1101/2020.03.23.20039362 – volume: 348 start-page: 1995 year: 2003 ident: 2023072812440334500_bib70 article-title: Identification of severe acute respiratory syndrome in Canada publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa030634 – volume: 14 start-page: R203 year: 2010 ident: 2023072812440334500_bib35 article-title: Clinical aspects and cytokine response in severe H1N1 influenza A virus infection publication-title: Crit. Care doi: 10.1186/cc9324 – ident: 2023072812440334500_bib10 doi: 10.1101/2020.03.24.004655 – volume: 371 start-page: 1507 year: 2014 ident: 2023072812440334500_bib57 article-title: Chimeric antigen receptor T cells for sustained remissions in leukemia publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa1407222 – volume: 15 start-page: 47 year: 2018 ident: 2023072812440334500_bib62 article-title: Chimeric antigen receptor T-cell therapy - assessment and management of toxicities publication-title: Nat. Rev. Clin. Oncol doi: 10.1038/nrclinonc.2017.148 – volume: 14 start-page: 2863 year: 2017 ident: 2023072812440334500_bib98 article-title: Effects of N-acetylcysteine treatment in acute respiratory distress syndrome: A meta-analysis publication-title: Exp. Ther. Med doi: 10.3892/etm.2017.4891 – year: 2020 ident: 2023072812440334500_bib24 article-title: Effectiveness of convalescent plasma therapy in severe COVID-19 patients publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.2004168117 – volume: 140 start-page: 1566 year: 1988 ident: 2023072812440334500_bib72 article-title: Antiviral action of tumor necrosis factor in human fibroblasts is not mediated by B cell stimulatory factor 2/IFN-beta 2, and is inhibited by specific antibodies to IFN-beta publication-title: J. Immunol doi: 10.4049/jimmunol.140.5.1566 – volume: 17 start-page: 131 year: 1974 ident: 2023072812440334500_bib78 article-title: Search for BK and SV40 virus reactivation in renal transplant recipients publication-title: Transplantation doi: 10.1097/00007890-197401000-00022 – volume: 133 start-page: 235 year: 2008 ident: 2023072812440334500_bib41 article-title: Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury publication-title: Cell doi: 10.1016/j.cell.2008.02.043 – volume: 326 start-page: 1358 year: 2003 ident: 2023072812440334500_bib91 article-title: Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis publication-title: BMJ doi: 10.1136/bmj.326.7403.1358 – volume: 140 start-page: 1686 year: 1989 ident: 2023072812440334500_bib42 article-title: Elevated interleukin-1 release by human alveolar macrophages during the adult respiratory distress syndrome publication-title: Am. Rev. Respir. Dis doi: 10.1164/ajrccm/140.6.1686 – volume: 368 start-page: 1509 year: 2013 ident: 2023072812440334500_bib32 article-title: Chimeric antigen receptor-modified T cells for acute lymphoid leukemia publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa1215134 – volume: 122 start-page: 2967 year: 2012 ident: 2023072812440334500_bib25 article-title: Viral acute lower respiratory infections impair CD8+ T cells through PD-1 publication-title: J. Clin. Invest doi: 10.1172/JCI62860 – ident: 2023072812440334500_bib19 doi: 10.1101/2020.03.27.20045427 – volume: 311 start-page: R906 year: 2016 ident: 2023072812440334500_bib14 article-title: Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol doi: 10.1152/ajpregu.00298.2016 – volume: 31 start-page: 1717 year: 2016 ident: 2023072812440334500_bib43 article-title: Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection publication-title: J. Korean Med. Sci doi: 10.3346/jkms.2016.31.11.1717 – volume: 73 start-page: 468 year: 2016 ident: 2023072812440334500_bib44 article-title: Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients publication-title: J. Infect doi: 10.1016/j.jinf.2016.08.005 – volume: 361 start-page: 680 year: 2009 ident: 2023072812440334500_bib67 article-title: Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa0904252 – volume: 27 start-page: 670 year: 2007 ident: 2023072812440334500_bib90 article-title: Molecular signature of CD8+ T cell exhaustion during chronic viral infection publication-title: Immunity doi: 10.1016/j.immuni.2007.09.006 – volume: 361 start-page: 1701 year: 2003 ident: 2023072812440334500_bib38 article-title: Clinical presentations and outcome of severe acute respiratory syndrome in children publication-title: Lancet doi: 10.1016/S0140-6736(03)13364-8 – volume: 8 start-page: 353 year: 2009 ident: 2023072812440334500_bib80 article-title: Early treatment with N-acetylcysteine in children with acute liver failure secondary to hepatitis A publication-title: Ann. Hepatol doi: 10.1016/S1665-2681(19)31749-1 – ident: 2023072812440334500_bib17 doi: 10.1101/2020.03.03.20030437 – volume: 1040 start-page: 85 year: 2013 ident: 2023072812440334500_bib71 article-title: Detection of pyroptosis by measuring released lactate dehydrogenase activity publication-title: Methods Mol. Biol doi: 10.1007/978-1-62703-523-1_7 – volume: 24 start-page: 731 year: 2018 ident: 2023072812440334500_bib30 article-title: CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade publication-title: Nat. Med doi: 10.1038/s41591-018-0041-7 – year: 2020 ident: 2023072812440334500_bib48 article-title: Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis publication-title: J. Med. Virol doi: 10.1002/jmv.25819 – volume: 362 start-page: 758 year: 1993 ident: 2023072812440334500_bib61 article-title: Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells publication-title: Nature doi: 10.1038/362758a0 – volume: 197 start-page: 757 year: 2018 ident: 2023072812440334500_bib4 article-title: Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome publication-title: Am. J. Respir. Crit. Care Med doi: 10.1164/rccm.201706-1172OC – volume: 395 start-page: 497 year: 2020 ident: 2023072812440334500_bib40 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet doi: 10.1016/S0140-6736(20)30183-5 – volume: 49 year: 2020 ident: 2023072812440334500_bib96 article-title: [A pathological report of three COVID-19 cases by minimally invasive autopsies] publication-title: Zhonghua Bing Li Xue Za Zhi – volume: 377 start-page: 562 year: 2017 ident: 2023072812440334500_bib85 article-title: Acute Respiratory Distress Syndrome publication-title: N. Engl. J. Med doi: 10.1056/NEJMra1608077 – volume: 348 start-page: 1977 year: 2003 ident: 2023072812440334500_bib87 article-title: A cluster of cases of severe acute respiratory syndrome in Hong Kong publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa030666 – volume: 58 start-page: 80 year: 2013 ident: 2023072812440334500_bib77 article-title: N-acetylcysteine in children with acute liver failure complicating dengue viral infection publication-title: Ceylon Med. J doi: 10.4038/cmj.v58i2.5684 – volume: 4 start-page: 533 year: 2010 ident: 2023072812440334500_bib47 article-title: Intravenous N-acetylcysteine in dengue-associated acute liver failure publication-title: Hepatol. Int doi: 10.1007/s12072-010-9176-4 – volume: 339 start-page: 786 year: 2013 ident: 2023072812440334500_bib82 article-title: Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway publication-title: Science doi: 10.1126/science.1232458 – volume: 19 start-page: 408 year: 2007 ident: 2023072812440334500_bib79 article-title: CD8 T cell dysfunction during chronic viral infection publication-title: Curr. Opin. Immunol doi: 10.1016/j.coi.2007.06.004 – volume: 323 start-page: 1406 year: 2020 ident: 2023072812440334500_bib6 article-title: Presumed Asymptomatic Carrier Transmission of COVID-19 publication-title: JAMA doi: 10.1001/jama.2020.2565 – volume: 334 start-page: 825 year: 2011 ident: 2023072812440334500_bib36 article-title: Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection publication-title: Science doi: 10.1126/science.1208421 – volume: 152 start-page: 687 year: 2010 ident: 2023072812440334500_bib49 article-title: High-dose N-acetylcysteine therapy for novel H1N1 influenza pneumonia publication-title: Ann. Intern. Med doi: 10.7326/0003-4819-152-10-201005180-00017 – volume: 2013 year: 2013 ident: 2023072812440334500_bib88 article-title: PD-L1 expression induced by the 2009 pandemic influenza A(H1N1) virus impairs the human T cell response publication-title: Clin. Dev. Immunol doi: 10.1155/2013/989673 – ident: 2023072812440334500_bib31 doi: 10.1101/2020.04.01.20048561 – volume: 2 start-page: 2 year: 2017 ident: 2023072812440334500_bib100 article-title: Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses publication-title: Sci. Immunol doi: 10.1126/sciimmunol.aan5393 – volume: 15 start-page: 88 year: 2013 ident: 2023072812440334500_bib54 article-title: Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response publication-title: Microbes Infect doi: 10.1016/j.micinf.2012.10.008 – volume: 314 start-page: 997 year: 2006 ident: 2023072812440334500_bib68 article-title: RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates publication-title: Science doi: 10.1126/science.1132998 – volume: 144 start-page: 601 year: 2011 ident: 2023072812440334500_bib65 article-title: IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology publication-title: Cell doi: 10.1016/j.cell.2011.01.011 – volume: 395 start-page: 1033 year: 2020 ident: 2023072812440334500_bib59 article-title: COVID-19: consider cytokine storm syndromes and immunosuppression publication-title: Lancet doi: 10.1016/S0140-6736(20)30628-0 – volume: 303 start-page: 1529 year: 2004 ident: 2023072812440334500_bib23 article-title: Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA publication-title: Science doi: 10.1126/science.1093616 – year: 2020 ident: 2023072812440334500_bib93 article-title: Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China publication-title: JAMA Intern. Med doi: 10.1001/jamainternmed.2020.0994 – volume: 130 start-page: 2295 year: 2017 ident: 2023072812440334500_bib37 article-title: Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T-cell therapy publication-title: Blood doi: 10.1182/blood-2017-06-793141 – ident: 2023072812440334500_bib99 doi: 10.1101/2020.03.24.20042655 – volume: 88 start-page: 11034 year: 2014 ident: 2023072812440334500_bib15 article-title: Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection publication-title: J. Virol doi: 10.1128/JVI.01505-14 – volume: 160 start-page: 521 year: 1984 ident: 2023072812440334500_bib2 article-title: Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence publication-title: J. Exp. Med doi: 10.1084/jem.160.2.521 – year: 2020 ident: 2023072812440334500_bib16 article-title: Clinical and immunological features of severe and moderate coronavirus disease 2019 publication-title: J. Clin. Invest. doi: 10.1172/JCI137244 – volume: 382 start-page: 970 year: 2020 ident: 2023072812440334500_bib75 article-title: Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany publication-title: N. Engl. J. Med doi: 10.1056/NEJMc2001468 – volume: 105 start-page: 190 year: 1994 ident: 2023072812440334500_bib83 article-title: N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study publication-title: Chest doi: 10.1378/chest.105.1.190 – volume: 11 start-page: 225 year: 2011 ident: 2023072812440334500_bib74 article-title: Epidemiological and clinical characteristics of childhood pandemic 2009 H1N1 virus infection: an observational cohort study publication-title: BMC Infect. Dis doi: 10.1186/1471-2334-11-225 – volume: 4 year: 2009 ident: 2023072812440334500_bib29 article-title: Effect of the novel influenza A (H1N1) virus in the human immune system publication-title: PLoS One doi: 10.1371/journal.pone.0008393 – ident: 2023072812440334500_bib94 – volume: 5 start-page: 97 year: 1993 ident: 2023072812440334500_bib26 article-title: N-acetylcysteine enhances T cell functions and T cell growth in culture publication-title: Int. Immunol doi: 10.1093/intimm/5.1.97 – volume: 15 start-page: 235 year: 2011 ident: 2023072812440334500_bib46 article-title: Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injury publication-title: Crit. Care doi: 10.1186/cc10437 – volume: 26 start-page: 502 year: 2020 ident: 2023072812440334500_bib95 article-title: Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding publication-title: Nat. Med. doi: 10.1038/s41591-020-0817-4 – volume: 439 start-page: 682 year: 2006 ident: 2023072812440334500_bib7 article-title: Restoring function in exhausted CD8 T cells during chronic viral infection publication-title: Nature doi: 10.1038/nature04444 – volume: 2 year: 2019 ident: 2023072812440334500_bib50 article-title: Corticosteroids as adjunctive therapy in the treatment of influenza publication-title: Cochrane Database Syst. Rev – volume: 57 start-page: 166 year: 2012 ident: 2023072812440334500_bib1 article-title: Successful use of intravenous N-acetylcysteine in dengue haemorrhagic fever with acute liver failure publication-title: Ceylon Med. J doi: 10.4038/cmj.v57i4.5085 – volume: 183 start-page: 1258 year: 2013 ident: 2023072812440334500_bib28 article-title: Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): role of the host immune response in pathogenesis publication-title: Am. J. Pathol doi: 10.1016/j.ajpath.2013.06.023 – volume: 6 start-page: 27912 year: 2016 ident: 2023072812440334500_bib84 article-title: Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition publication-title: Sci. Rep doi: 10.1038/srep27912 – volume: 28 start-page: 389 year: 1998 ident: 2023072812440334500_bib55 article-title: Sodium selenite and N-acetylcysteine in antiretroviral-naive HIV-1-infected patients: a randomized, controlled pilot study publication-title: Eur. J. Clin. Invest doi: 10.1046/j.1365-2362.1998.00301.x – volume: 124 start-page: 188 year: 2014 ident: 2023072812440334500_bib52 article-title: Current concepts in the diagnosis and management of cytokine release syndrome publication-title: Blood doi: 10.1182/blood-2014-05-552729 – ident: 2023072812440334500_bib21 doi: 10.3389/fimmu.2020.00827 – volume: 367 start-page: 1260 year: 2020 ident: 2023072812440334500_bib92 article-title: Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation publication-title: Science doi: 10.1126/science.abb2507 – volume: 8 start-page: 2424 year: 2006 ident: 2023072812440334500_bib66 article-title: Human memory T cell responses to SARS-CoV E protein publication-title: Microbes Infect doi: 10.1016/j.micinf.2006.05.008 |
| SSID | ssj0014456 |
| Score | 2.7017553 |
| SecondaryResourceType | review_article |
| Snippet | The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a... This Perspective explores the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and... |
| SourceID | pubmedcentral proquest pubmed crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| SubjectTerms | Adaptive Immunity - drug effects Adaptive Immunity - immunology Betacoronavirus - drug effects Betacoronavirus - immunology Betacoronavirus - pathogenicity Coronavirus Infections - immunology Coronavirus Infections - pathology Coronavirus Infections - therapy COVID-19 Cytokine Release Syndrome - immunology Cytokine Release Syndrome - pathology Cytokine Release Syndrome - therapy Humans Hypoxia - pathology Hypoxia - therapy Immunity, Innate - drug effects Immunity, Innate - immunology Infectious Disease and Host Defense Inflammation - immunology Inflammation - pathology Inflammation - therapy Innate Immunity and Inflammation Interleukin-6 - antagonists & inhibitors Interleukin-6 - immunology Lymphopenia - immunology Lymphopenia - pathology Lymphopenia - therapy Macrophages - immunology Macrophages - pathology Middle East Respiratory Syndrome Coronavirus - immunology Middle East Respiratory Syndrome Coronavirus - pathogenicity Pandemics Pneumonia, Viral - immunology Pneumonia, Viral - pathology Pneumonia, Viral - therapy Respiration, Artificial Respiratory Distress Syndrome - pathology Respiratory Distress Syndrome - therapy SARS-CoV-2 Severe acute respiratory syndrome-related coronavirus - immunology Severe acute respiratory syndrome-related coronavirus - pathogenicity |
| Title | The many faces of the anti-COVID immune response |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32353870 https://www.proquest.com/docview/2397676030 https://pubmed.ncbi.nlm.nih.gov/PMC7191310 |
| Volume | 217 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swEBelg7KXsa3dltENDbqn4MyWLUt5LOlGV2g76Ad5M9aHSVjrlDZ92V_fO0l27LSDrS_GOIpk7nec7qzf3RGyV1meMSV4xBIVR1liRFQqzpH2V7kmNco4guxJfniRHU35dNVj02WXLNVI_3kyr-Q5qMIzwBWzZP8D2XZSeAD3gC9cAWG4_jPG13hgXzliVTjuB1nNo8np5c-D4RyzP7AxiiPC9lg_q5ww5432Kv2vH7hfghrNSp89doZdh-9m5XB_1Br0xRUY0d-eLGPM8GDU_ZbA4hXnKZCQwHJUeGBw-yhRsWtEIX5FcoXfQoLdzGI8CZZdw8p8VmbQoPxJgx3LDA22xaIAzG2d3WEg7ptrB17KUpjd9xhZK5D963giIOpMMdHuBYNoweV8T1umD4SMrolv-94h_wGW_tZd-CXZalbpOymPIo91Am3HIzl_TV4F8Oi-14s3ZMPWb8nWccBum8QAMUX1oE496KKioB50pR7Uqwdt1GOHXPz4fj45jEKDjEhnPF5GmulEyyRJrRFCxoaDt5crCNC5Ti04Zrkyiaqq1Ahw8xTcGiXhnfN8bFSl9Th9RzbrRW0_EKrBlVSayTIZl-Cj5tJgIUBwxqUWvIztgAwbiRQ6VI_HJiZXhWMxyKwAURaNKAfkazv6xldN-cu4L41wCzBreFZV1nZxf1cw9JNFDlvQgLz3wm5nalAaENGDoR2AJdP7v9TzmSudHhTl47P_uUs2l7f39hN4okv12enZA5qsigE |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+many+faces+of+the+anti-COVID+immune+response&rft.jtitle=The+Journal+of+experimental+medicine&rft.au=Vardhana%2C+Santosha+A.&rft.au=Wolchok%2C+Jedd+D.&rft.date=2020-06-01&rft.pub=Rockefeller+University+Press&rft.issn=0022-1007&rft.eissn=1540-9538&rft.volume=217&rft.issue=6&rft_id=info:doi/10.1084%2Fjem.20200678&rft_id=info%3Apmid%2F32353870&rft.externalDocID=PMC7191310 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1007&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1007&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1007&client=summon |