Emergence and Adaptation of a Novel Highly Pathogenic H7N9 Influenza Virus in Birds and Humans from a 2013 Human-Infecting Low-Pathogenic Ancestor

• Published in: Journal of virology Vol. 92; no. 2
• Main Authors: Qi, Wenbao, Jia, Weixin, Liu, Di, Li, Jing, Bi, Yuhai, Xie, Shumin, Li, Bo, Hu, Tao, Du, Yingying, Xing, Li, Zhang, Jiahao, Zhang, Fuchun, Wei, Xiaoman, Eden, John-Sebastian, Li, Huanan, Tian, Huaiyu, Li, Wei, Su, Guanming, Lao, Guangjie, Xu, Chenggang, Xu, Bing, Liu, Wenjun, Zhang, Guihong, Ren, Tao, Holmes, Edward C., Cui, Jie, Shi, Weifeng, Gao, George F., Liao, Ming
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.01.2018
• Subjects: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Chickens; Communicable Diseases, Emerging - virology; Female; Genetic Diversity and Evolution; Genetic Variation; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; Humans; Influenza A Virus, H7N9 Subtype - classification; Influenza A Virus, H7N9 Subtype - isolation & purification; Influenza A Virus, H7N9 Subtype - pathogenicity; Influenza A Virus, H7N9 Subtype - physiology; Influenza in Birds - mortality; Influenza in Birds - virology; Influenza, Human - virology; Mice; Mutation; Orthomyxoviridae Infections - mortality; Orthomyxoviridae Infections - virology; Phylogeny; Protein Binding; Virulence; adaptation; highly pathogenic H7N9 influenza virus; multiple basic amino acids; emergence
• ISSN: 0022-538X; 1098-5514; 1098-5514
• DOI: 10.1128/JVI.00921-17

Since its emergence in 2013, the H7N9 low-pathogenic avian influenza virus (LPAIV) has been circulating in domestic poultry in China, causing five waves of human infections. A novel H7N9 highly pathogenic avian influenza virus (HPAIV) variant possessing multiple basic amino acids at the cleavage sit...