OneD: increasing reproducibility of Hi-C samples with abnormal karyotypes

• Published in: Nucleic acids research Vol. 46; no. 8; p. e49
• Main Authors: Vidal, Enrique, le Dily, François, Quilez, Javier, Stadhouders, Ralph, Cuartero, Yasmina, Graf, Thomas, Marti-Renom, Marc A, Beato, Miguel, Filion, Guillaume J
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 04.05.2018
• Subjects: Abnormal Karyotype; Animals; Base Composition; Bias; Cell Line; Chromosome Aberrations; Computational Biology - methods; Computational Biology - statistics & numerical data; Computer Simulation; DNA Copy Number Variations; Genetic Techniques; Humans; Markov Chains; Methods Online; Mice; Models, Statistical; Reproducibility of Results

Abstract The three-dimensional conformation of genomes is an essential component of their biological activity. The advent of the Hi-C technology enabled an unprecedented progress in our understanding of genome structures. However, Hi-C is subject to systematic biases that can compromise downstream a...