Structural network alterations and neurological dysfunction in cerebral amyloid angiopathy

• Published in: Brain (London, England : 1878) Vol. 138; no. 1; pp. 179 - 188
• Main Authors: Reijmer, Y. D., Fotiadis, P., Martinez-Ramirez, S., Salat, D. H., Schultz, A., Shoamanesh, A., Ayres, A. M., Vashkevich, A., Rosas, D., Schwab, K., Leemans, A., Biessels, G.-J., Rosand, J., Johnson, K. A., Viswanathan, A., Gurol, M. E., Greenberg, S. M.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2015
• Subjects: Aged; Analysis of Variance; Brain - pathology; Cerebral Amyloid Angiopathy - complications; Cognition Disorders - etiology; Cohort Studies; Cross-Sectional Studies; Diffusion Tensor Imaging; Female; Functional Laterality; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Models, Neurological; Nervous System Diseases - etiology; Nervous System Diseases - pathology; Neural Pathways - pathology; Original; small vessel disease; amyloid imaging; tractography; mild cognitive impairment; stroke: imaging; executive function

Cerebral amyloid angiopathy is a common form of small-vessel disease and an important risk factor for cognitive impairment. The mechanisms linking small-vessel disease to cognitive impairment are not well understood. We hypothesized that in patients with cerebral amyloid angiopathy, multiple small s...