Allosteric Regulation of HIV-1 Capsid Structure for Gag Assembly, Virion Production, and Viral Infectivity by a Disordered Interdomain Linker

• Published in: Journal of virology Vol. 93; no. 17
• Main Authors: Koma, Takaaki, Kotani, Osamu, Miyakawa, Kei, Ryo, Akihide, Yokoyama, Masaru, Doi, Naoya, Adachi, Akio, Sato, Hironori, Nomaguchi, Masako
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2019
• Subjects: Structure and Assembly; Gag-CA; HIV-1; assembly; interdomain linker; virus particle production

HIV-1 particle production and infection are highly ordered processes. Viral Gag proteins play a central role in the assembly and disassembly of viral molecules. Of these, capsid protein (CA) is a major contributor to the Gag-Gag interactions. CA consists of two structured domains, i.e., N-terminal (...