Untargeted LC–HRMS profiling followed by targeted fractionation to discover new taste-active compounds in spirits
[Display omitted] •New methodology to discover taste-active compounds.•Untargeted metabolomic profiling of 48 cognacs.•Isolation and characterization of one sweet-tasting compound.•First identification of Alc-diHDDC in oak wood and spirits. Taste is a key driver of food and beverage acceptability du...
Saved in:
Published in | Food chemistry Vol. 359; p. 129825 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
15.10.2021
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | [Display omitted]
•New methodology to discover taste-active compounds.•Untargeted metabolomic profiling of 48 cognacs.•Isolation and characterization of one sweet-tasting compound.•First identification of Alc-diHDDC in oak wood and spirits.
Taste is a key driver of food and beverage acceptability due to its role in consumers’ pleasure. The great interest that natural food and beverages now arouse lies notably in the complexity of their taste, which in turn is related to a wide range of taste-active compounds. Going beyond the classic divide between targeted and untargeted strategies, an integrative methodology to spirits was applied. Untargeted profiling of several cognac spirits was implemented by LC–HRMS to identify compounds of interest among hundreds of ions. A targeted fractionation protocol was then developed. By using HRMS and NMR, dihydrodehydrodiconiferyl alcohol was identified and described for the first time in spirits and oak wood. It was characterized as sweet at 2 mg/L in two matrices and was quantified in spirits up to 4 mg/L. These findings demonstrated how this methodology is relevant and effective to discover new taste-active compounds. |
---|---|
AbstractList | Taste is a key driver of food and beverage acceptability due to its role in consumers' pleasure. The great interest that natural food and beverages now arouse lies notably in the complexity of their taste, which in turn is related to a wide range of taste-active compounds. Going beyond the classic divide between targeted and untargeted strategies, an integrative methodology to spirits was applied. Untargeted profiling of several cognac spirits was implemented by LC-HRMS to identify compounds of interest among hundreds of ions. A targeted fractionation protocol was then developed. By using HRMS and NMR, dihydrodehydrodiconiferyl alcohol was identified and described for the first time in spirits and oak wood. It was characterized as sweet at 2 mg/L in two matrices and was quantified in spirits up to 4 mg/L. These findings demonstrated how this methodology is relevant and effective to discover new taste-active compounds. [Display omitted] •New methodology to discover taste-active compounds.•Untargeted metabolomic profiling of 48 cognacs.•Isolation and characterization of one sweet-tasting compound.•First identification of Alc-diHDDC in oak wood and spirits. Taste is a key driver of food and beverage acceptability due to its role in consumers’ pleasure. The great interest that natural food and beverages now arouse lies notably in the complexity of their taste, which in turn is related to a wide range of taste-active compounds. Going beyond the classic divide between targeted and untargeted strategies, an integrative methodology to spirits was applied. Untargeted profiling of several cognac spirits was implemented by LC–HRMS to identify compounds of interest among hundreds of ions. A targeted fractionation protocol was then developed. By using HRMS and NMR, dihydrodehydrodiconiferyl alcohol was identified and described for the first time in spirits and oak wood. It was characterized as sweet at 2 mg/L in two matrices and was quantified in spirits up to 4 mg/L. These findings demonstrated how this methodology is relevant and effective to discover new taste-active compounds. Taste is a key driver of food and beverage acceptability due to its role in consumers’ pleasure. The great interest that natural food and beverages now arouse lies notably in the complexity of their taste, which in turn is related to a wide range of taste-active compounds. Going beyond the classic divide between targeted and untargeted strategies, an integrative methodology to spirits was applied. Untargeted profiling of several cognac spirits was implemented by LC–HRMS to identify compounds of interest among hundreds of ions. A targeted fractionation protocol was then developed. By using HRMS and NMR, dihydrodehydrodiconiferyl alcohol was identified and described for the first time in spirits and oak wood. It was characterized as sweet at 2 mg/L in two matrices and was quantified in spirits up to 4 mg/L. These findings demonstrated how this methodology is relevant and effective to discover new taste-active compounds. |
ArticleNumber | 129825 |
Author | Bahammou, Delphine Winstel, Delphine Marchal, Axel Albertin, Warren Waffo-Téguo, Pierre |
Author_xml | – sequence: 1 givenname: Delphine surname: Winstel fullname: Winstel, Delphine email: delphine.winstel@u-bordeaux.fr – sequence: 2 givenname: Delphine surname: Bahammou fullname: Bahammou, Delphine email: delphine.bahammou@u-bordeaux.fr – sequence: 3 givenname: Warren surname: Albertin fullname: Albertin, Warren email: warren.albertin@u-bordeaux.fr – sequence: 4 givenname: Pierre surname: Waffo-Téguo fullname: Waffo-Téguo, Pierre email: pierre.waffo-teguo@u-bordeaux.fr – sequence: 5 givenname: Axel surname: Marchal fullname: Marchal, Axel email: axel.marchal@u-bordeaux.fr |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33940473$$D View this record in MEDLINE/PubMed https://hal.inrae.fr/hal-03297010$$DView record in HAL |
BookMark | eNqFkc1uGyEQgFGVqnHSvkLEsT2sM8D-3hpZbV3JUaUmOSOWHRKsXXBh7Si3vEPesE9SVpv42gug4ZsZzXxn5MR5h4RcMFgyYOXldmm87_QDDksOnC0Zb2pevCMLVlciq6DiJ2QBAuqsZnl5Ss5i3AIAB1Z_IKdCNDnklViQeOdGFe5xxI5uVn-fX9a_r2_oLnhje-vuqfF97x_TZ_tEj6AJSo_WOzUddPS0s1H7Awbq8DFhccRsIg5ItR92fu-6SK2jcWeDHeNH8t6oPuKn1_uc3H3_drtaZ5tfP36urjaZzgsYsxbLHFljOs2LquOFwLLIWV0IVZsChUjPhnEmQDc8ZyZv8hZaVWPTCFZppsU5-TLXfVC93AU7qPAkvbJyfbWRUwwEbypgcGCJ_TyzafQ_e4yjHNJM2PfKod9HyQvO02qhrBNazqgOPsaA5libgZzkyK18kyMnOXKWkxIvXnvs2wG7Y9qbjQR8nQFMWzlYDDJqi05jZwPqUXbe_q_HP120ph0 |
CitedBy_id | crossref_primary_10_1016_j_foodchem_2023_137826 crossref_primary_10_1016_j_tifs_2024_104481 crossref_primary_10_1016_j_foodchem_2021_131963 crossref_primary_10_1002_csc2_21022 crossref_primary_10_1016_j_foodchem_2022_132235 crossref_primary_10_1016_j_crfs_2024_100747 |
Cites_doi | 10.1021/acs.jnatprod.6b00142 10.1016/j.foodres.2012.11.027 10.1016/j.aca.2010.01.065 10.1021/ac502805w 10.1002/chem.200801181 10.1021/acs.jnatprod.6b00379 10.1039/b415422c 10.1016/j.foodchem.2020.126748 10.1016/j.aca.2018.09.017 10.1021/jf073031n 10.1021/acs.jnatprod.0c00106 10.1016/j.foodchem.2018.08.070 10.3390/metabo8020031 10.1038/s41598-020-58193-2 10.3390/molecules24010117 10.1016/j.foodchem.2012.08.062 10.1021/acs.jafc.5b05056 10.1021/acs.jafc.7b01969 10.1002/0470010398 10.1021/acs.jnatprod.8b00682 10.1016/j.tet.2006.10.018 10.1021/acs.jnatprod.7b00737 10.1039/C9NP00004F 10.1016/j.foodchem.2014.04.095 10.1016/S0031-9422(96)00885-0 10.1021/ac202499a 10.3389/fchem.2018.00029 10.1016/B978-0-12-397922-3.00004-6 10.1186/1471-2105-11-395 10.1021/jf803388w 10.1021/acs.jafc.0c02619 10.1021/acs.jafc.7b05674 10.1007/s13361-016-1513-y 10.1016/0031-9422(93)85098-C 10.1007/s00217-005-0143-6 |
ContentType | Journal Article |
Copyright | 2021 Elsevier Ltd Copyright © 2021 Elsevier Ltd. All rights reserved. Attribution - NonCommercial |
Copyright_xml | – notice: 2021 Elsevier Ltd – notice: Copyright © 2021 Elsevier Ltd. All rights reserved. – notice: Attribution - NonCommercial |
DBID | NPM AAYXX CITATION 7X8 1XC VOOES |
DOI | 10.1016/j.foodchem.2021.129825 |
DatabaseName | PubMed CrossRef MEDLINE - Academic Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access) |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Economics Chemistry Diet & Clinical Nutrition Environmental Sciences |
EISSN | 1873-7072 |
EndPage | 129825 |
ExternalDocumentID | oai_HAL_hal_03297010v1 10_1016_j_foodchem_2021_129825 33940473 S0308814621008311 |
Genre | Journal Article |
GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JM 9JN AABNK AABVA AACTN AAEDT AAEDW AAIAV AAIKC AAIKJ AAKOC AALRI AAMNW AAOAW AAQFI AARLI AATLK AAXUO ABFNM ABFRF ABGRD ABGSF ABJNI ABMAC ABUDA ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADECG ADEZE ADQTV ADUVX AEBSH AEFWE AEHWI AEKER AENEX AEQOU AFKWA AFTJW AFXIZ AFZHZ AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AJSZI ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CBWCG CS3 DOVZS DU5 EBS EFJIC EFLBG EO8 EO9 EP2 EP3 F5P FDB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA IHE J1W K-O KOM KZ1 LW9 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 ROL RPZ SAB SCC SDF SDG SDP SES SPC SPCBC SSA SSK SSU SSZ T5K WH7 ~G- ~KM AAHBH AAXKI AKRWK NPM RIG 29H 53G AALCJ AAQXK AAYJJ AAYXX ABXDB ACNNM ADMUD AFJKZ AGHFR AGRDE AI. ASPBG AVWKF AZFZN CITATION EJD FEDTE FGOYB G-2 HLV HVGLF HZ~ R2- SCB SEW VH1 WUQ Y6R 7X8 1XC VOOES |
ID | FETCH-LOGICAL-c450t-be64e19fdc257d253e6541853a8f5e33185912130c9241f494b0ba8e99317c1c3 |
IEDL.DBID | AIKHN |
ISSN | 0308-8146 |
IngestDate | Fri Sep 06 12:49:42 EDT 2024 Fri Aug 16 02:47:34 EDT 2024 Thu Sep 26 17:38:46 EDT 2024 Sat Sep 28 08:23:15 EDT 2024 Fri Feb 23 02:43:42 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | LOD LC–HRMS Untargeted approach Taste-active compounds Sweetness Metabolomic Alc-diHDDC Quantitation PCA LOQ |
Language | English |
License | Copyright © 2021 Elsevier Ltd. All rights reserved. Attribution - NonCommercial: http://creativecommons.org/licenses/by-nc |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c450t-be64e19fdc257d253e6541853a8f5e33185912130c9241f494b0ba8e99317c1c3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-4053-2998 |
OpenAccessLink | https://hal.inrae.fr/hal-03297010 |
PMID | 33940473 |
PQID | 2522187068 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | hal_primary_oai_HAL_hal_03297010v1 proquest_miscellaneous_2522187068 crossref_primary_10_1016_j_foodchem_2021_129825 pubmed_primary_33940473 elsevier_sciencedirect_doi_10_1016_j_foodchem_2021_129825 |
PublicationCentury | 2000 |
PublicationDate | 2021-10-15 |
PublicationDateYYYYMMDD | 2021-10-15 |
PublicationDate_xml | – month: 10 year: 2021 text: 2021-10-15 day: 15 |
PublicationDecade | 2020 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Food chemistry |
PublicationTitleAlternate | Food Chem |
PublicationYear | 2021 |
Publisher | Elsevier Ltd Elsevier |
Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
References | Gammacurta, Waffo-Teguo, Winstel, Cretin, Sindt, Dubourdieu, Marchal (b0045) 2019; 82 Gil, Reynes, Cazals, Enjalbal, Sabatier, Saucier (b0065) 2020; 10 Son, Hwang, Kim, Ahn, Park, Van Den Berg, Lee (b0165) 2009; 57 Guidance for Industry. (2018). Bioanalytical Method Validation. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM). Stupak, Goodall, Tomaniova, Pulkrabova, Hajslova (b0175) 2018; 1042 Ribéreau-Gayon, P., Glories, Y., Maujean, A., & Dubourdieu, D. (Eds.). (2006). Handbook of Enology, Volume 2: The Chemistry of Wine - Stabilization and Treatments (2 edition). Wiley. Cretin, Waffo-Teguo, Dubourdieu, Marchal (b0030) 2019; 272 Winstel, Gautier, Marchal (b0190) 2020; 68 Kew, Goodall, Clarke, Uhrín (b0095) 2017; 28 Winstel, Marchal (b0195) 2019; 24 Gougeon, Lucio, De Boel, Frommberger, Hertkorn, Peyron, Schmitt-Kopplin (b0070) 2009; 15 F. Hanawa M. Shiro Y. Hayashi Heartwood constituents of Betula Maximowicziana Phytochemistry 45 3 1997 589 595. Garcia, Vaz, Corilo, Ramires, Saraiva, Sanvido, Eberlin (b0055) 2013; 51 Marchal, Prida, Dubourdieu (b0110) 2016; 64 Sindt, Gammacurta, Waffo-Teguo, Dubourdieu, Marchal (b0160) 2016; 79 Collins, Zweigenbaum, Ebeler (b0025) 2014; 163 García-Muñoz, Álvarez-Corral, Jiménez-González, López-Sánchez, Rosales, Muñoz-Dorado, Rodríguez-García (b0060) 2006; 62 Møller, Catharino, Eberlin (b0120) 2005; 130 Pluskal, Castillo, Villar-Briones, Orešič (b0140) 2010; 11 Weinges, Mueller, Kloss, Jaggy (b0185) 1970; 736 Nothias, Nothias-Esposito, da Silva, Wang, Protsyuk, Zhang, Dorrestein (b0125) 2018; 81 De Paepe, Servaes, Noten, Diels, De Loose, Van Droogenbroeck, Voorspoels (b0035) 2013; 136 Gammacurta, Waffo-Teguo, Winstel, Dubourdieu, Marchal (b0050) 2020; 83 Suga, Ohta, Munesada, Ide, Kurokawa, Shimizu, Ohta (b0180) 1993; 33 Frank, Zehentbauer, Hofmann (b0040) 2006; 222 Liu, Rose, DaSilva, Johnson, Seeram (b0100) 2017; 65 Cantagrel, Mazerolles, Vidal, Galy (b0020) 1992 A. Marchal Recherches sur les bases moléculaires de la saveur sucrée des vins secs: Approches analytique et sensorielle [Thèse, Bordeaux 2] 2010 http://www.theses.fr/2010BOR21779. Boudah, S., Paris, A., & Junot, C. (2013). Chapter Four—Liquid Chromatography Coupled to Mass Spectrometry-Based Metabolomics and the Concept of Biomarker. In D. Rolin (Ed.), Advances in Botanical Research (Vol. 67, pp. 159–218). Academic Press. https://doi.org/10.1016/B978-0-12-397922-3.00004-6. Piggott (b0135) 1983 Hoffmann, Krug, Hüttel, Müller (b0085) 2014; 86 Hufnagel, Hofmann (b0090) 2008; 56 Roullier-Gall, Signoret, Hemmler, Witting, Kanawati, Schäfer, Schmitt-Kopplin (b0155) 2018; 6 Spreng, Hofmann (b0170) 2018; 66 Marchal, Waffo-Téguo, Génin, Mérillon, Dubourdieu (b0115) 2011; 83 Blaženović, Kind, Ji, Fiehn (b0005) 2018; 8 Roullier-Gall, Signoret, Coelho, Hemmler, Kajdan, Lucio, Schmitt-Kopplin (b0150) 2020; 323 Wolfender, Litaudon, Touboul, Queiroz (b0200) 2019; 36 Cabral, Allard, Marcourt, Young, Queiroz, Wolfender (b0015) 2016; 79 Peters, Rijk, Bovee, Nijrolder, Lommen, Nielen (b0130) 2010; 664 10.1016/j.foodchem.2021.129825_b0010 10.1016/j.foodchem.2021.129825_b0075 Cantagrel (10.1016/j.foodchem.2021.129825_b0020) 1992 Sindt (10.1016/j.foodchem.2021.129825_b0160) 2016; 79 Marchal (10.1016/j.foodchem.2021.129825_b0115) 2011; 83 García-Muñoz (10.1016/j.foodchem.2021.129825_b0060) 2006; 62 Son (10.1016/j.foodchem.2021.129825_b0165) 2009; 57 Piggott (10.1016/j.foodchem.2021.129825_b0135) 1983 Marchal (10.1016/j.foodchem.2021.129825_b0110) 2016; 64 Blaženović (10.1016/j.foodchem.2021.129825_b0005) 2018; 8 Peters (10.1016/j.foodchem.2021.129825_b0130) 2010; 664 Roullier-Gall (10.1016/j.foodchem.2021.129825_b0155) 2018; 6 Cretin (10.1016/j.foodchem.2021.129825_b0030) 2019; 272 10.1016/j.foodchem.2021.129825_b0145 Stupak (10.1016/j.foodchem.2021.129825_b0175) 2018; 1042 Wolfender (10.1016/j.foodchem.2021.129825_b0200) 2019; 36 De Paepe (10.1016/j.foodchem.2021.129825_b0035) 2013; 136 Gammacurta (10.1016/j.foodchem.2021.129825_b0045) 2019; 82 Hoffmann (10.1016/j.foodchem.2021.129825_b0085) 2014; 86 Liu (10.1016/j.foodchem.2021.129825_b0100) 2017; 65 Winstel (10.1016/j.foodchem.2021.129825_b0190) 2020; 68 Frank (10.1016/j.foodchem.2021.129825_b0040) 2006; 222 Spreng (10.1016/j.foodchem.2021.129825_b0170) 2018; 66 Weinges (10.1016/j.foodchem.2021.129825_b0185) 1970; 736 Gil (10.1016/j.foodchem.2021.129825_b0065) 2020; 10 Garcia (10.1016/j.foodchem.2021.129825_b0055) 2013; 51 Collins (10.1016/j.foodchem.2021.129825_b0025) 2014; 163 Gougeon (10.1016/j.foodchem.2021.129825_b0070) 2009; 15 10.1016/j.foodchem.2021.129825_b0105 Pluskal (10.1016/j.foodchem.2021.129825_b0140) 2010; 11 Hufnagel (10.1016/j.foodchem.2021.129825_b0090) 2008; 56 Møller (10.1016/j.foodchem.2021.129825_b0120) 2005; 130 Cabral (10.1016/j.foodchem.2021.129825_b0015) 2016; 79 Kew (10.1016/j.foodchem.2021.129825_b0095) 2017; 28 Nothias (10.1016/j.foodchem.2021.129825_b0125) 2018; 81 10.1016/j.foodchem.2021.129825_b0080 Roullier-Gall (10.1016/j.foodchem.2021.129825_b0150) 2020; 323 Gammacurta (10.1016/j.foodchem.2021.129825_b0050) 2020; 83 Winstel (10.1016/j.foodchem.2021.129825_b0195) 2019; 24 Suga (10.1016/j.foodchem.2021.129825_b0180) 1993; 33 |
References_xml | – volume: 56 start-page: 1376 year: 2008 end-page: 1386 ident: b0090 article-title: Orosensory-Directed Identification of Astringent Mouthfeel and Bitter-Tasting Compounds in Red Wine publication-title: Journal of Agricultural and Food Chemistry contributor: fullname: Hofmann – volume: 62 start-page: 12182 year: 2006 end-page: 12190 ident: b0060 article-title: Synthesis of dihydrodehydrodiconiferyl alcohol and derivatives through intramolecular C-H insertion publication-title: Tetrahedron contributor: fullname: Rodríguez-García – volume: 81 start-page: 758 year: 2018 end-page: 767 ident: b0125 article-title: Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation publication-title: Journal of Natural Products contributor: fullname: Dorrestein – volume: 323 start-page: 126748 year: 2020 ident: b0150 article-title: Influence of regionality and maturation time on the chemical fingerprint of whisky publication-title: Food Chemistry contributor: fullname: Schmitt-Kopplin – year: 1992 ident: b0020 article-title: Élaboration et Connaissance des Spiritueux: Recherche de la qualité contributor: fullname: Galy – volume: 28 start-page: 200 year: 2017 end-page: 213 ident: b0095 article-title: Chemical Diversity and Complexity of Scotch Whisky as Revealed by High-Resolution Mass Spectrometry publication-title: Journal of The American Society for Mass Spectrometry contributor: fullname: Uhrín – volume: 83 start-page: 9629 year: 2011 end-page: 9637 ident: b0115 article-title: Identification of New Natural Sweet Compounds in Wine Using Centrifugal Partition Chromatography-Gustatometry and Fourier Transform Mass Spectrometry publication-title: Analytical Chemistry contributor: fullname: Dubourdieu – volume: 64 start-page: 618 year: 2016 end-page: 626 ident: b0110 article-title: New Approach for Differentiating Sessile and Pedunculate Oak: Development of a LC-HRMS Method To Quantitate Triterpenoids in Wood publication-title: Journal of Agricultural and Food Chemistry contributor: fullname: Dubourdieu – volume: 82 start-page: 265 year: 2019 end-page: 275 ident: b0045 article-title: Triterpenoids from Quercus petraea: Identification in Wines and Spirits and Sensory Assessment publication-title: Journal of Natural Products contributor: fullname: Marchal – volume: 130 start-page: 890 year: 2005 end-page: 897 ident: b0120 article-title: Electrospray ionization mass spectrometry fingerprinting of whisky: Immediate proof of origin and authenticity publication-title: Analyst contributor: fullname: Eberlin – volume: 66 start-page: 720 year: 2018 end-page: 731 ident: b0170 article-title: Activity-Guided Identification of publication-title: Journal of Agricultural and Food Chemistry contributor: fullname: Hofmann – volume: 65 start-page: 4289 year: 2017 end-page: 4295 ident: b0100 article-title: Isolation, Identification, and Biological Evaluation of Phenolic Compounds from a Traditional North American Confectionery, Maple Sugar publication-title: Journal of Agricultural and Food Chemistry contributor: fullname: Seeram – volume: 664 start-page: 77 year: 2010 end-page: 88 ident: b0130 article-title: Identification of anabolic steroids and derivatives using bioassay-guided fractionation, UHPLC/TOFMS analysis and accurate mass database searching publication-title: Analytica Chimica Acta contributor: fullname: Nielen – volume: 86 start-page: 10780 year: 2014 end-page: 10788 ident: b0085 article-title: Improving Natural Products Identification through Targeted LC-MS/MS in an Untargeted Secondary Metabolomics Workflow publication-title: Analytical Chemistry contributor: fullname: Müller – volume: 272 start-page: 388 year: 2019 end-page: 395 ident: b0030 article-title: Taste-guided isolation of sweet-tasting compounds from grape seeds, structural elucidation and identification in wines publication-title: Food Chemistry contributor: fullname: Marchal – volume: 15 start-page: 600 year: 2009 end-page: 611 ident: b0070 article-title: Expressing Forest Origins in the Chemical Composition of Cooperage Oak Woods and Corresponding Wines by Using FTICR-MS. publication-title: European Journal contributor: fullname: Schmitt-Kopplin – volume: 51 start-page: 98 year: 2013 end-page: 106 ident: b0055 article-title: Whisky analysis by electrospray ionization-Fourier transform mass spectrometry publication-title: Food Research International contributor: fullname: Eberlin – volume: 136 start-page: 368 year: 2013 end-page: 375 ident: b0035 article-title: An improved mass spectrometric method for identification and quantification of phenolic compounds in apple fruits publication-title: Food Chemistry contributor: fullname: Voorspoels – volume: 163 start-page: 186 year: 2014 end-page: 196 ident: b0025 article-title: Profiling of nonvolatiles in whiskeys using ultra high pressure liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC–QTOF MS) publication-title: Food Chemistry contributor: fullname: Ebeler – volume: 222 start-page: 492 year: 2006 end-page: 508 ident: b0040 article-title: Bioresponse-guided decomposition of roast coffee beverage and identification of key bitter taste compounds publication-title: European Food Research and Technology contributor: fullname: Hofmann – volume: 36 start-page: 855 year: 2019 end-page: 868 ident: b0200 article-title: Innovative omics-based approaches for prioritisation and targeted isolation of natural products – new strategies for drug discovery publication-title: Natural Product Reports contributor: fullname: Queiroz – volume: 83 start-page: 1611 year: 2020 end-page: 1622 ident: b0050 article-title: Isolation of Taste-Active Triterpenoids from Quercus robur: Sensory Assessment and Identification in Wines and Spirit publication-title: Journal of Natural Products contributor: fullname: Marchal – volume: 24 start-page: 117 year: 2019 ident: b0195 article-title: Lignans in Spirits: Chemical Diversity, Quantification, and Sensory Impact of (±)-Lyoniresinol publication-title: Molecules contributor: fullname: Marchal – volume: 57 start-page: 1481 year: 2009 end-page: 1490 ident: b0165 article-title: Metabolomic Studies on Geographical Grapes and Their Wines Using 1H NMR Analysis Coupled with Multivariate Statistics publication-title: Journal of Agricultural and Food Chemistry contributor: fullname: Lee – volume: 6 year: 2018 ident: b0155 article-title: Usage of FT-ICR-MS Metabolomics for Characterizing the Chemical Signatures of Barrel-Aged Whisky publication-title: Frontiers in Chemistry contributor: fullname: Schmitt-Kopplin – volume: 8 start-page: 31 year: 2018 ident: b0005 article-title: Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics publication-title: Metabolites contributor: fullname: Fiehn – volume: 79 start-page: 2270 year: 2016 end-page: 2278 ident: b0015 article-title: Targeted Isolation of Indolopyridoquinazoline Alkaloids from Conchocarpus fontanesianus Based on Molecular Networks publication-title: Journal of Natural Products contributor: fullname: Wolfender – volume: 10 start-page: 1170 year: 2020 ident: b0065 article-title: Discrimination of rosé wines using shotgun metabolomics with a genetic algorithm and MS ion intensity ratios publication-title: Scientific Reports contributor: fullname: Saucier – year: 1983 ident: b0135 article-title: . E contributor: fullname: Piggott – volume: 79 start-page: 2432 year: 2016 end-page: 2438 ident: b0160 article-title: Taste-Guided Isolation of Bitter Lignans from publication-title: Journal of Natural Products contributor: fullname: Marchal – volume: 1042 start-page: 60 year: 2018 end-page: 70 ident: b0175 article-title: A novel approach to assess the quality and authenticity of Scotch Whisky based on gas chromatography coupled to high resolution mass spectrometry publication-title: Analytica Chimica Acta contributor: fullname: Hajslova – volume: 736 year: 1970 ident: b0185 article-title: Phenolic natural products. XIII. Isolation and determination of the constitution of an optically active dehydrodiconiferyl alcohol from the seeds of the milk thistle Silybum marianum publication-title: Justus Liebigs Annalen der Chemie contributor: fullname: Jaggy – volume: 68 start-page: 7434 year: 2020 end-page: 7443 ident: b0190 article-title: Role of Oak Coumarins in the Taste of Wines and Spirits: Identification, Quantitation, and Sensory Contribution through Perceptive Interactions publication-title: Journal of Agricultural and Food Chemistry contributor: fullname: Marchal – volume: 11 start-page: 395 year: 2010 ident: b0140 article-title: MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data publication-title: BMC Bioinformatics contributor: fullname: Orešič – volume: 33 start-page: 1395 year: 1993 end-page: 1401 ident: b0180 article-title: Endogenous pine wood nematicidal substances in pines, Pinus massoniana, P. strobus and P. palustris publication-title: Phytochemistry contributor: fullname: Ohta – volume: 79 start-page: 2432 issue: 10 year: 2016 ident: 10.1016/j.foodchem.2021.129825_b0160 article-title: Taste-Guided Isolation of Bitter Lignans from Quercus petraea and Their Identification in Wine publication-title: Journal of Natural Products doi: 10.1021/acs.jnatprod.6b00142 contributor: fullname: Sindt – volume: 51 start-page: 98 issue: 1 year: 2013 ident: 10.1016/j.foodchem.2021.129825_b0055 article-title: Whisky analysis by electrospray ionization-Fourier transform mass spectrometry publication-title: Food Research International doi: 10.1016/j.foodres.2012.11.027 contributor: fullname: Garcia – volume: 664 start-page: 77 issue: 1 year: 2010 ident: 10.1016/j.foodchem.2021.129825_b0130 article-title: Identification of anabolic steroids and derivatives using bioassay-guided fractionation, UHPLC/TOFMS analysis and accurate mass database searching publication-title: Analytica Chimica Acta doi: 10.1016/j.aca.2010.01.065 contributor: fullname: Peters – volume: 86 start-page: 10780 issue: 21 year: 2014 ident: 10.1016/j.foodchem.2021.129825_b0085 article-title: Improving Natural Products Identification through Targeted LC-MS/MS in an Untargeted Secondary Metabolomics Workflow publication-title: Analytical Chemistry doi: 10.1021/ac502805w contributor: fullname: Hoffmann – volume: 15 start-page: 600 issue: 3 year: 2009 ident: 10.1016/j.foodchem.2021.129825_b0070 article-title: Expressing Forest Origins in the Chemical Composition of Cooperage Oak Woods and Corresponding Wines by Using FTICR-MS. Chemistry – A publication-title: European Journal doi: 10.1002/chem.200801181 contributor: fullname: Gougeon – volume: 79 start-page: 2270 issue: 9 year: 2016 ident: 10.1016/j.foodchem.2021.129825_b0015 article-title: Targeted Isolation of Indolopyridoquinazoline Alkaloids from Conchocarpus fontanesianus Based on Molecular Networks publication-title: Journal of Natural Products doi: 10.1021/acs.jnatprod.6b00379 contributor: fullname: Cabral – volume: 130 start-page: 890 issue: 6 year: 2005 ident: 10.1016/j.foodchem.2021.129825_b0120 article-title: Electrospray ionization mass spectrometry fingerprinting of whisky: Immediate proof of origin and authenticity publication-title: Analyst doi: 10.1039/b415422c contributor: fullname: Møller – year: 1983 ident: 10.1016/j.foodchem.2021.129825_b0135 contributor: fullname: Piggott – volume: 323 start-page: 126748 year: 2020 ident: 10.1016/j.foodchem.2021.129825_b0150 article-title: Influence of regionality and maturation time on the chemical fingerprint of whisky publication-title: Food Chemistry doi: 10.1016/j.foodchem.2020.126748 contributor: fullname: Roullier-Gall – volume: 1042 start-page: 60 year: 2018 ident: 10.1016/j.foodchem.2021.129825_b0175 article-title: A novel approach to assess the quality and authenticity of Scotch Whisky based on gas chromatography coupled to high resolution mass spectrometry publication-title: Analytica Chimica Acta doi: 10.1016/j.aca.2018.09.017 contributor: fullname: Stupak – volume: 56 start-page: 1376 issue: 4 year: 2008 ident: 10.1016/j.foodchem.2021.129825_b0090 article-title: Orosensory-Directed Identification of Astringent Mouthfeel and Bitter-Tasting Compounds in Red Wine publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf073031n contributor: fullname: Hufnagel – volume: 83 start-page: 1611 issue: 5 year: 2020 ident: 10.1016/j.foodchem.2021.129825_b0050 article-title: Isolation of Taste-Active Triterpenoids from Quercus robur: Sensory Assessment and Identification in Wines and Spirit publication-title: Journal of Natural Products doi: 10.1021/acs.jnatprod.0c00106 contributor: fullname: Gammacurta – volume: 272 start-page: 388 year: 2019 ident: 10.1016/j.foodchem.2021.129825_b0030 article-title: Taste-guided isolation of sweet-tasting compounds from grape seeds, structural elucidation and identification in wines publication-title: Food Chemistry doi: 10.1016/j.foodchem.2018.08.070 contributor: fullname: Cretin – ident: 10.1016/j.foodchem.2021.129825_b0105 – ident: 10.1016/j.foodchem.2021.129825_b0075 – volume: 8 start-page: 31 issue: 2 year: 2018 ident: 10.1016/j.foodchem.2021.129825_b0005 article-title: Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics publication-title: Metabolites doi: 10.3390/metabo8020031 contributor: fullname: Blaženović – volume: 736 year: 1970 ident: 10.1016/j.foodchem.2021.129825_b0185 article-title: Phenolic natural products. XIII. Isolation and determination of the constitution of an optically active dehydrodiconiferyl alcohol from the seeds of the milk thistle Silybum marianum publication-title: Justus Liebigs Annalen der Chemie contributor: fullname: Weinges – volume: 10 start-page: 1170 issue: 1 year: 2020 ident: 10.1016/j.foodchem.2021.129825_b0065 article-title: Discrimination of rosé wines using shotgun metabolomics with a genetic algorithm and MS ion intensity ratios publication-title: Scientific Reports doi: 10.1038/s41598-020-58193-2 contributor: fullname: Gil – volume: 24 start-page: 117 issue: 1 year: 2019 ident: 10.1016/j.foodchem.2021.129825_b0195 article-title: Lignans in Spirits: Chemical Diversity, Quantification, and Sensory Impact of (±)-Lyoniresinol publication-title: Molecules doi: 10.3390/molecules24010117 contributor: fullname: Winstel – volume: 136 start-page: 368 issue: 2 year: 2013 ident: 10.1016/j.foodchem.2021.129825_b0035 article-title: An improved mass spectrometric method for identification and quantification of phenolic compounds in apple fruits publication-title: Food Chemistry doi: 10.1016/j.foodchem.2012.08.062 contributor: fullname: De Paepe – volume: 64 start-page: 618 issue: 3 year: 2016 ident: 10.1016/j.foodchem.2021.129825_b0110 article-title: New Approach for Differentiating Sessile and Pedunculate Oak: Development of a LC-HRMS Method To Quantitate Triterpenoids in Wood publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/acs.jafc.5b05056 contributor: fullname: Marchal – volume: 65 start-page: 4289 issue: 21 year: 2017 ident: 10.1016/j.foodchem.2021.129825_b0100 article-title: Isolation, Identification, and Biological Evaluation of Phenolic Compounds from a Traditional North American Confectionery, Maple Sugar publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/acs.jafc.7b01969 contributor: fullname: Liu – ident: 10.1016/j.foodchem.2021.129825_b0145 doi: 10.1002/0470010398 – volume: 82 start-page: 265 issue: 2 year: 2019 ident: 10.1016/j.foodchem.2021.129825_b0045 article-title: Triterpenoids from Quercus petraea: Identification in Wines and Spirits and Sensory Assessment publication-title: Journal of Natural Products doi: 10.1021/acs.jnatprod.8b00682 contributor: fullname: Gammacurta – volume: 62 start-page: 12182 issue: 52 year: 2006 ident: 10.1016/j.foodchem.2021.129825_b0060 article-title: Synthesis of dihydrodehydrodiconiferyl alcohol and derivatives through intramolecular C-H insertion publication-title: Tetrahedron doi: 10.1016/j.tet.2006.10.018 contributor: fullname: García-Muñoz – volume: 81 start-page: 758 issue: 4 year: 2018 ident: 10.1016/j.foodchem.2021.129825_b0125 article-title: Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation publication-title: Journal of Natural Products doi: 10.1021/acs.jnatprod.7b00737 contributor: fullname: Nothias – year: 1992 ident: 10.1016/j.foodchem.2021.129825_b0020 contributor: fullname: Cantagrel – volume: 36 start-page: 855 issue: 6 year: 2019 ident: 10.1016/j.foodchem.2021.129825_b0200 article-title: Innovative omics-based approaches for prioritisation and targeted isolation of natural products – new strategies for drug discovery publication-title: Natural Product Reports doi: 10.1039/C9NP00004F contributor: fullname: Wolfender – volume: 163 start-page: 186 year: 2014 ident: 10.1016/j.foodchem.2021.129825_b0025 article-title: Profiling of nonvolatiles in whiskeys using ultra high pressure liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC–QTOF MS) publication-title: Food Chemistry doi: 10.1016/j.foodchem.2014.04.095 contributor: fullname: Collins – ident: 10.1016/j.foodchem.2021.129825_b0080 doi: 10.1016/S0031-9422(96)00885-0 – volume: 83 start-page: 9629 issue: 24 year: 2011 ident: 10.1016/j.foodchem.2021.129825_b0115 article-title: Identification of New Natural Sweet Compounds in Wine Using Centrifugal Partition Chromatography-Gustatometry and Fourier Transform Mass Spectrometry publication-title: Analytical Chemistry doi: 10.1021/ac202499a contributor: fullname: Marchal – volume: 6 year: 2018 ident: 10.1016/j.foodchem.2021.129825_b0155 article-title: Usage of FT-ICR-MS Metabolomics for Characterizing the Chemical Signatures of Barrel-Aged Whisky publication-title: Frontiers in Chemistry doi: 10.3389/fchem.2018.00029 contributor: fullname: Roullier-Gall – ident: 10.1016/j.foodchem.2021.129825_b0010 doi: 10.1016/B978-0-12-397922-3.00004-6 – volume: 11 start-page: 395 issue: 1 year: 2010 ident: 10.1016/j.foodchem.2021.129825_b0140 article-title: MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-11-395 contributor: fullname: Pluskal – volume: 57 start-page: 1481 issue: 4 year: 2009 ident: 10.1016/j.foodchem.2021.129825_b0165 article-title: Metabolomic Studies on Geographical Grapes and Their Wines Using 1H NMR Analysis Coupled with Multivariate Statistics publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf803388w contributor: fullname: Son – volume: 68 start-page: 7434 issue: 28 year: 2020 ident: 10.1016/j.foodchem.2021.129825_b0190 article-title: Role of Oak Coumarins in the Taste of Wines and Spirits: Identification, Quantitation, and Sensory Contribution through Perceptive Interactions publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/acs.jafc.0c02619 contributor: fullname: Winstel – volume: 66 start-page: 720 issue: 3 year: 2018 ident: 10.1016/j.foodchem.2021.129825_b0170 article-title: Activity-Guided Identification of in Vitro Antioxidants in Beer publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/acs.jafc.7b05674 contributor: fullname: Spreng – volume: 28 start-page: 200 issue: 1 year: 2017 ident: 10.1016/j.foodchem.2021.129825_b0095 article-title: Chemical Diversity and Complexity of Scotch Whisky as Revealed by High-Resolution Mass Spectrometry publication-title: Journal of The American Society for Mass Spectrometry doi: 10.1007/s13361-016-1513-y contributor: fullname: Kew – volume: 33 start-page: 1395 issue: 6 year: 1993 ident: 10.1016/j.foodchem.2021.129825_b0180 article-title: Endogenous pine wood nematicidal substances in pines, Pinus massoniana, P. strobus and P. palustris publication-title: Phytochemistry doi: 10.1016/0031-9422(93)85098-C contributor: fullname: Suga – volume: 222 start-page: 492 issue: 5-6 year: 2006 ident: 10.1016/j.foodchem.2021.129825_b0040 article-title: Bioresponse-guided decomposition of roast coffee beverage and identification of key bitter taste compounds publication-title: European Food Research and Technology doi: 10.1007/s00217-005-0143-6 contributor: fullname: Frank |
SSID | ssj0002018 |
Score | 2.4683688 |
Snippet | [Display omitted]
•New methodology to discover taste-active compounds.•Untargeted metabolomic profiling of 48 cognacs.•Isolation and characterization of one... Taste is a key driver of food and beverage acceptability due to its role in consumers' pleasure. The great interest that natural food and beverages now arouse... Taste is a key driver of food and beverage acceptability due to its role in consumers’ pleasure. The great interest that natural food and beverages now arouse... |
SourceID | hal proquest crossref pubmed elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 129825 |
SubjectTerms | Environmental Sciences LC–HRMS Metabolomic Quantitation Sweetness Taste-active compounds Untargeted approach |
Title | Untargeted LC–HRMS profiling followed by targeted fractionation to discover new taste-active compounds in spirits |
URI | https://dx.doi.org/10.1016/j.foodchem.2021.129825 https://www.ncbi.nlm.nih.gov/pubmed/33940473 https://search.proquest.com/docview/2522187068 https://hal.inrae.fr/hal-03297010 |
Volume | 359 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NbtQwEB612wNcUCl_aaEyCHHLbhw7TXJcLVQByh4oK_VmOV5bpEJJ1aRFXKq-A2_IkzATJyuQQBw4JnF-5JnMN2PPzAfw0mWpdFyY0MVRv1qVhFoIHaZEf4TxRJTbvtvn8qhYyXdnydkWLMZaGEqrHGy_t-m9tR7OzIbZnF1U1eyUOq3QAlbMe7osDIF2EI6knMDO_O37YrkxyIhxmd9MyPoVr18Khc-nrmnWOD1UlB7zKaJfRqzZf8ao7c-ULPk3T7RHpONduDe4kmzuv_Y-bNl6D-4sRga3PQheV7Zjr9jQ-_MLW46t93HcWJHcPoB2VfuEcLtmJ4sft9-Ljx9OmWfzRmRjDnWl-YoXy29sM9Bd-pKIXrKsaxjV91I-KENHHYeh9oS6N6aM0taJvallVc1oZ7_q2oewOn7zaVGEAxlDaGQSdWFpj6TluVsb_MnXcSIsMYgj2OvMJVZQEXZO7eEigxEddzKXZVTqzKL_w1PDjXgEk7qp7RNgMi7JkSql00aWXGtrE2EwMOM2MVJHAczG6VcXvueGGpPRztUoMEUCU15gAeSjlNRv2qMQGP557wsU6-ZF1G67mJ8oOheJOE8xYL3mATwfpa5QiLSpomvbXLUqRgeW02ZxFsBjrw6bZwminZep2P-PzzuAu3REcMmTpzDpLq_sM_SDuvIQtqc3_HDQ9p-arAY7 |
link.rule.ids | 230,315,786,790,891,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6V7aFcEJRXeBqEuKUbx3aTHFcLVUq3e6BdqTfLydpqKpRUTdqKG_-Bf8gvYSaJVyCBOHC1ncTyTObheXwA71yaSMdFGbo46m-rVGiEMGFC8EfoT0SZ7bt9Lvfzlfx0ps62YO5rYSitcpT9g0zvpfU4Mh1Pc3pZVdMT6rRCF1gx7-Gy0AXalirh8QS2Z4dH-XIjkFHHpUMwIe1vvH4pFL7Yc02zxuOhovSY76H2Swk1-8866s45JUv-zRLtNdLBfbg3mpJsNuz2AWzZehd25h7BbReCD5Xt2Hs29v78wpa-9T6u8xXJ7UNoV_WQEG7XbDH_8e17_vn4hA1o3qjZmENeaW5xsvjKNgvd1VAS0VOWdQ2j-l7KB2VoqOMy5J7Q9MKUUdo6oTe1rKoZRfarrn0Eq4OPp_M8HMEYwlKqqAsLuy8tz9y6xJ98HSthCUEclb1JnbKCirAzag8XlejRcSczWUSFSS3aPzwpeSkew6RuavsUmIwLMqQK6UwpC26MtUqU6Jhxq0ppogCm_vj15dBzQ_tktAvtCaaJYHogWACZp5L-jXs0KoZ_PvsWybr5ELXbzmcLTWORiLMEHdYbHsAbT3WNRKSgiqltc93qGA1YTsHiNIAnAzts3iUIdl4m4tl_bO817OSnxwu9OFwePYe7NEOqk6sXMOmuru1LtIm64tXI8z8B5RkIKw |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Untargeted+LC%E2%80%93HRMS+profiling+followed+by+targeted+fractionation+to+discover+new+taste-active+compounds+in+spirits&rft.jtitle=Food+chemistry&rft.au=Winstel%2C+Delphine&rft.au=Bahammou%2C+Delphine&rft.au=Albertin%2C+Warren&rft.au=Waffo-T%C3%A9guo%2C+Pierre&rft.date=2021-10-15&rft.pub=Elsevier+Ltd&rft.issn=0308-8146&rft.eissn=1873-7072&rft.volume=359&rft_id=info:doi/10.1016%2Fj.foodchem.2021.129825&rft.externalDocID=S0308814621008311 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0308-8146&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0308-8146&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0308-8146&client=summon |