Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation

• Published in: World journal of gastroenterology : WJG Vol. 24; no. 1; pp. 5 - 14
• Main Authors: Shen, Zhao-Hua, Zhu, Chang-Xin, Quan, Yong-Sheng, Yang, Zhen-Yu, Wu, Shuai, Luo, Wei-Wei, Tan, Bei, Wang, Xiao-Yan
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 07.01.2018
• Subjects: Animals; Bacteria - growth & development; Bacteria - immunology; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - immunology; Colitis, Ulcerative - microbiology; Colitis, Ulcerative - therapy; Colon - immunology; Colon - microbiology; Fecal Microbiota Transplantation - adverse effects; Gastrointestinal Microbiome; Host-Pathogen Interactions; Humans; Probiotics - adverse effects; Probiotics - therapeutic use; Review; Treatment Outcome; Probiotics; Clinical application; Fecal microbiota transplantation; Intestinal microbiota; Mechanism; Ulcerative colitis

Ulcerative colitis (UC) is an inflammatory disease that mainly affects the colon and rectum. It is believed that genetic factors, host immune system disorders, intestinal microbiota dysbiosis, and environmental factors contribute to the pathogenesis of UC. However, studies on the role of intestinal...