Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects

• Published in: Neuroscience letters Vol. 571; pp. 34 - 38
• Main Authors: Beach, Thomas G., Carew, Jeremiah, Serrano, Geidy, Adler, Charles H., Shill, Holly A., Sue, Lucia I., Sabbagh, Marwan N., Akiyama, Haruhiko, Cuenca, Nicolás
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 13.06.2014
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - metabolism; Autopsy; Case-Control Studies; Diagnosis; Female; Ganglion cell; Humans; Lewy body; Male; Melanopsin; Middle Aged; Nerve Fibers - metabolism; Parkinson Disease - metabolism; Parkinson Disease - pathology; Pathology; Retinal Neurons - metabolism; Retinal Neurons - ultrastructure; Pathology; Diagnosis; Autopsy; Melanopsin; Lewy body; Ganglion cell

•Structural and functional retinal changes are present in Parkinson's disease (PD).•Phosphorylated α-synuclein (psyn) is a specific biomarker of PD.•Psyn-immunoreactive nerve fibers were present in the retina in 7/9 subjects with PD.•Psyn-immunoreactive neuronal perikarya were present in 1 PD s...