Histopathological findings in 29 lymph node biopsies with increased IgG4 plasma cells

• Published in: Modern pathology Vol. 25; no. 3; pp. 480 - 491
• Main Authors: Grimm, Kate E, Barry, Todd S, Chizhevsky, Vladislav, Hii, Anselm, Weiss, Lawrence M, Siddiqi, Imran N, Brynes, Russell K, O'Malley, Dennis P
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2012; Elsevier Limited
• Subjects: Adult; Aged; Aged, 80 and over; Antigens; Autoimmune Diseases - immunology; Autoimmune Diseases - pathology; Biomarkers - metabolism; Biopsy; Disease; Female; Flow Cytometry; Germinal Center - pathology; Humans; Hyperplasia; Immunoglobulin G - blood; Immunophenotyping; Laboratory Medicine; Lymph Nodes - pathology; Lymphatic Diseases - blood; Lymphatic Diseases - pathology; Lymphatic system; Male; Medicine; Medicine & Public Health; Middle Aged; original-article; Pancreatitis; Pathology; Plasma; Plasma Cells - immunology; Plasma Cells - pathology; Sclerosis - immunology; Sclerosis - pathology; Stains & staining; Young Adult; Los Angeles California; United States > US; IgG4; IgG4-related sclerosing disease; lymph node; reactive lymphadenopathy

IgG4-related sclerosing disease encompasses a family of disorders associated with increased numbers of IgG4 plasma cells and mass forming lesions in various tissues. Lymphadenopathy is a common finding, seen in up to 80% of cases. In the largest series of cases to date, we describe histologic, immun...