Histopathological findings in 29 lymph node biopsies with increased IgG4 plasma cells
IgG4-related sclerosing disease encompasses a family of disorders associated with increased numbers of IgG4 plasma cells and mass forming lesions in various tissues. Lymphadenopathy is a common finding, seen in up to 80% of cases. In the largest series of cases to date, we describe histologic, immun...
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Published in | Modern pathology Vol. 25; no. 3; pp. 480 - 491 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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01.03.2012
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Abstract | IgG4-related sclerosing disease encompasses a family of disorders associated with increased numbers of IgG4 plasma cells and mass forming lesions in various tissues. Lymphadenopathy is a common finding, seen in up to 80% of cases. In the largest series of cases to date, we describe histologic, immunohistochemical, special stain and flow cytometric findings in 29 cases of enlarged lymph nodes with increased IgG4 plasma cells. Lymph node biopsies showed all resection specimens; no needle core biopsies of tissue were evaluated. Cases were considered to have increased numbers of IgG4 plasma cells using the histological criteria outlined by Cheuk and Chan (2010): IgG4 plasma cells >50 cells in a high-power field and >40% of IgG-positive plasma cells positive for IgG4. Additionally, increased intrafollicular plasma cells were a common finding. The lymph nodes showed a variety of reactive histological features including follicular hyperplasia, progressive transformation of germinal centers, interfollicular expansions, variable degrees of fibrosis, increased histiocytes and occasionally an appearance similar to that of plasma cell Castleman disease. |
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AbstractList | IgG4-related sclerosing disease encompasses a family of disorders associated with increased numbers of IgG4 plasma cells and mass forming lesions in various tissues. Lymphadenopathy is a common finding, seen in up to 80% of cases. In the largest series of cases to date, we describe histologic, immunohistochemical, special stain and flow cytometric findings in 29 cases of enlarged lymph nodes with increased IgG4 plasma cells. Lymph node biopsies showed all resection specimens; no needle core biopsies of tissue were evaluated. Cases were considered to have increased numbers of IgG4 plasma cells using the histological criteria outlined by Cheuk and Chan (2010): IgG4 plasma cells >50 cells in a high-power field and >40% of IgG-positive plasma cells positive for IgG4. Additionally, increased intrafollicular plasma cells were a common finding. The lymph nodes showed a variety of reactive histological features including follicular hyperplasia, progressive transformation of germinal centers, interfollicular expansions, variable degrees of fibrosis, increased histiocytes and occasionally an appearance similar to that of plasma cell Castleman disease. |
Author | Hii, Anselm Weiss, Lawrence M Grimm, Kate E Barry, Todd S Siddiqi, Imran N Brynes, Russell K Chizhevsky, Vladislav O'Malley, Dennis P |
Author_xml | – sequence: 1 givenname: Kate E surname: Grimm fullname: Grimm, Kate E organization: Department of Pathology, Clarient /GE Healthcare – sequence: 2 givenname: Todd S surname: Barry fullname: Barry, Todd S organization: Department of Pathology, Clarient /GE Healthcare – sequence: 3 givenname: Vladislav surname: Chizhevsky fullname: Chizhevsky, Vladislav organization: Department of Pathology, Clarient /GE Healthcare – sequence: 4 givenname: Anselm surname: Hii fullname: Hii, Anselm organization: Department of Pathology, Clarient /GE Healthcare – sequence: 5 givenname: Lawrence M surname: Weiss fullname: Weiss, Lawrence M organization: Department of Pathology, Clarient /GE Healthcare – sequence: 6 givenname: Imran N surname: Siddiqi fullname: Siddiqi, Imran N organization: University of Southern California, Los Angeles County Hospital – sequence: 7 givenname: Russell K surname: Brynes fullname: Brynes, Russell K organization: University of Southern California, Los Angeles County Hospital – sequence: 8 givenname: Dennis P surname: O'Malley fullname: O'Malley, Dennis P email: domalley@clarientinc.com organization: Department of Pathology, Clarient /GE Healthcare, Department of Hematopathology, MD Anderson Cancer Center, University of Texas |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22080064$$D View this record in MEDLINE/PubMed |
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Keywords | IgG4; IgG4-related sclerosing disease; lymph node; reactive lymphadenopathy |
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SubjectTerms | Adult Aged Aged, 80 and over Antigens Autoimmune Diseases - immunology Autoimmune Diseases - pathology Biomarkers - metabolism Biopsy Disease Female Flow Cytometry Germinal Center - pathology Humans Hyperplasia Immunoglobulin G - blood Immunophenotyping Laboratory Medicine Lymph Nodes - pathology Lymphatic Diseases - blood Lymphatic Diseases - pathology Lymphatic system Male Medicine Medicine & Public Health Middle Aged original-article Pancreatitis Pathology Plasma Plasma Cells - immunology Plasma Cells - pathology Sclerosis - immunology Sclerosis - pathology Stains & staining Young Adult |
Title | Histopathological findings in 29 lymph node biopsies with increased IgG4 plasma cells |
URI | https://link.springer.com/article/10.1038/modpathol.2011.177 https://www.ncbi.nlm.nih.gov/pubmed/22080064 https://www.proquest.com/docview/925048331 https://search.proquest.com/docview/1008827096 https://search.proquest.com/docview/926153673 |
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