Obesity, metabolic disease and the pancreas-Quantitative imaging of pancreatic fat

The association between pancreatic fat, obesity and metabolic disease is well-documented, and although a potentially exciting target for novel therapies, remains poorly understood. Non-invasive quantitative imaging-derived biomarkers can provide insights into pathophysiology and potentially provide...

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Published inBritish journal of radiology Vol. 91; no. 1089; p. 20180267
Main Authors Sakai, Naomi S, Taylor, Stuart A, Chouhan, Manil D
Format Journal Article
LanguageEnglish
Published England The British Institute of Radiology 01.09.2018
Subjects
Adipose Tissue - diagnostic imaging
Body Composition
Humans
Magnetic Resonance Imaging
Metabolic Syndrome - pathology
Obesity - pathology
Pancreas - diagnostic imaging
Pancreas - pathology
Pancreatic Diseases - diagnostic imaging
Pancreatic Diseases - pathology
Pancreatic Diseases - physiopathology
The role of imaging in obesity special feature: Review
Tomography, X-Ray Computed
Online AccessGet full text

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Abstract The association between pancreatic fat, obesity and metabolic disease is well-documented, and although a potentially exciting target for novel therapies, remains poorly understood. Non-invasive quantitative imaging-derived biomarkers can provide insights into pathophysiology and potentially provide robust trial endpoints for development of new treatments. In this review, we provide an overview of the pathophysiology of non-alcoholic fatty pancreas disease and associations with metabolic factors, obesity and diabetes. We then explore approaches to pancreatic fat quantification using ultrasound, CT and MRI, reviewing the strengths, limitations and current published evidence in the assessment of pancreatic fat. Finally, we explore the broader challenges of pancreatic fat quantification as we move toward translating these methods into the clinical setting.
AbstractList The association between pancreatic fat, obesity and metabolic disease is well-documented, and although a potentially exciting target for novel therapies, remains poorly understood. Non-invasive quantitative imaging-derived biomarkers can provide insights into pathophysiology and potentially provide robust trial endpoints for development of new treatments. In this review, we provide an overview of the pathophysiology of non-alcoholic fatty pancreas disease and associations with metabolic factors, obesity and diabetes. We then explore approaches to pancreatic fat quantification using ultrasound, CT and MRI, reviewing the strengths, limitations and current published evidence in the assessment of pancreatic fat. Finally, we explore the broader challenges of pancreatic fat quantification as we move toward translating these methods into the clinical setting.
Author Taylor, Stuart A
Sakai, Naomi S
Chouhan, Manil D
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Snippet The association between pancreatic fat, obesity and metabolic disease is well-documented, and although a potentially exciting target for novel therapies,...
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SubjectTerms Adipose Tissue - diagnostic imaging
Body Composition
Humans
Magnetic Resonance Imaging
Metabolic Syndrome - pathology
Obesity - pathology
Pancreas - diagnostic imaging
Pancreas - pathology
Pancreatic Diseases - diagnostic imaging
Pancreatic Diseases - pathology
Pancreatic Diseases - physiopathology
The role of imaging in obesity special feature: Review
Tomography, X-Ray Computed
Title Obesity, metabolic disease and the pancreas-Quantitative imaging of pancreatic fat
URI https://www.ncbi.nlm.nih.gov/pubmed/29869917
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https://pubmed.ncbi.nlm.nih.gov/PMC6223168
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